Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!
etoxazole (Ref: S 1283)
** Yl 5301 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

A commonly used insecticide which currently has EU approval for use. It has a low aqueous solubility, a low volatility and, based on its chemical properties, would not be expected to leach to groundwater. It is non-mobile, not persistent in most soils but may be persistent in some water systems depending upon conditions. It not highly toxic to humans but is toxic to fish and aquatic invertebrates. It has a low toxicity to birds, honey bees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for etoxazole

Description: An insecticide for use in the field and in the glasshouse, on, for example, pome fruits, cotton and vegetables to control phytophagous mites

Example pests controlled: Phytophagous mites

Example applications: Apples; Pears; Plums; Cherry; Citrus; Cotton; Tomato; Eggplant; Strawberries; Ornamentals

Efficacy & activity: Substance has been on the EU market for sometime and has been successfully evaluated for performance by research and according to the EU's Uniform Principles

Availability status: Current

Introduction & key dates: 1994, first reported; 1998, first registered Japan

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Greece/UK
Date inclusion expires 31/07/2020
EU Candidate for substitution (CfS) Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule existing in the S- and R-forms
Chemical formula C21H23F2N02
Canonical SMILES CCOC1=C(C=CC(=C1)C(C)(C)C)C2COC(=N2)C3=C(C=CC=C3F)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) IXSZQYVWNJNRAL-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C21H23F2NO2/c1-5-25-18-11-13(21(2,3)4)9-10-14(18)17-12-26-20(24-17)19-15(22)7-6-8-16(19)23/h6-11,17H,5,12H2,1-4H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Acaricide
Substance group Diphenyl oxazoline
Minimum active substance purity 948 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Non-systemic with contact action. A moulting hormone agonist.
CAS RN 153233-91-1
EC number -
CIPAC number 623
US EPA chemical code 107091
PubChem CID 153974
Molecular mass (g mol-1) 359.42
PIN (Preferred Identification Name) rac-(4R)-2-(2,6-difluorophenyl)-4-(4-tert-butyl-2-ethoxyphenyl)-4,5-dihydro-1,3-oxazole
IUPAC name (RS)-5-tert-butyl-2-[2-(2,6-difluorophenyl)-4,5-dihydro-1,3-oxazol-4-yl]phenetole
CAS name 2-(2,6-difluorophenyl)-4-(4-(1,1-dimethylethyl)-2-ethoxyphenyl)-4,5-dihydrooxazole
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 10B
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Blattella germanica
Physical state White crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically -
Example products using this active -
UK LERAP status None
Formulation and application details Foliar application.


ENVIRONMENTAL FATE

for etoxazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.07 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 249000 A5 - Ethyl acetate -
309000 A5 - Acetone -
104000 A5 - Methanol -
252000 A5 - Xylene -
Melting point (oC) 101.5 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 293 A5 -
Flashpoint (oC) 457 L3 -
Octanol-water partition coefficient at pH 7, 20oC P 3.31 X 1005 Calculated -
Log P 5.52 A5 High
Bulk density (g ml-1)/Specific gravity 1.24 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: Not determinable
Vapour pressure at 20oC (mPa) 0.007 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.60 X 10-02 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.15 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.61 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 220nm = 17379; [Acidic solution: 222.5nm = 16670; [Basic solution: 272.5nm = 3993 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 19.3 A5 Non-persistent
DT50 (lab at 20oC) 19.31 A5 Non-persistent
DT50 (field) 7.33 A5 Non-persistent
DT90 (lab at 20oC) 93.0 A5 -
DT90 (field) 36.0 A5 -
DT50 modelling endpoint 74.1 A5 Worst case -
Note EU 2018 dossier lab studies DT50 range 9.3-74.1 days, DT90 range 19.9-246.2 days, Soils = 8; Field studies DT50 range 0.48-23.2 days, DT90 range 8.4-77.2 days, Soils= 11
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 3.3 R4 -
Note Published literature RL50 range 1.6-6.6 days, 3 field crops, various matrices, n=6
Aqueous photolysis DT50 (days) at pH 7 Value 17 A3 Slow
Note 130hrs at pH 9, summer sunlight equivalent
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 161 A5 Persistent
Note pH sensitive: 9.6 days @ pH 5, 165 days @ pH 9, all at 20 degC.
Water-sediment DT50 (days) 79.5 A5 Moderately fast
Water phase only DT50 (days) 1.45 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 92.0 A5 Non-mobile
Kfoc 6650
1/n 0.93
Notes and range EU 2018 dossier Kf range 66-131 mL/g, Kfoc range 4910-11000 mL/g, OC 0.6-2.4%, pH 4.3-7.4, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
N-(2,6-difluorobenzoyl)-4-tert-butyl-2-ethoxybenzamine This metabolite may cause environmental pollution, click here for further information Soil   0.104   Major fraction, Relevant
2 amino-2-(4-tert-butyl-2-ethoxyphenyl)ethyl 2',6'-difluorobenzoate hydrochloride This metabolite may cause environmental pollution, click here for further information Soil   0.240   Major fraction, Relevant
2 amino-2-(4-tert-butyl-2-ethoxyphenyl)ethanol This metabolite may cause environmental pollution, click here for further information Soil   0.448   Major Fraction, Relevant
4-(4-tert-butyl-2-ethoxyphenyl)-2-(2,6-difluorophenyl)oxazole This metabolite may cause environmental pollution, click here for further information Soil   0.231   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
- R-04 Soil 0.124 -
- R-12 Soil 0.085 -


ECOTOXICOLOGY

for etoxazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 2900 A5 Whole fish Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 5200 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 2.8 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.015 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0071 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0002 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 25 A5 Chironomus Spp. Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants > 67.2 A5 Lactuca sativa, Cucumis sativus, Brassica oleracea, Brassica oleracea, Zea mays
Vegetative vigour, ER50
as g/ha
-
> 67.2 - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 10 C4 Raphidocelis subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 200 A5 Apis mellifera Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 200 A5 Apis mellifera Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 4.4 A4 Bombus terrestris, as LC50, mg/L Moderate
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic NOEC, reproduction (mg kg-1) 5.0 A5 Eisenia foetida 56 days Moderate
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) 10 A5 Folsomia candida, 28d -
Other arthropod (1) LR50 g ha-1 55.0 >
A5 Aphidius rhopalosiphi
-
% Effect Moderately harmful AA2 Typhlodromus pyri -
Other arthropod (2) LR50 g ha-1 - - -
% Effect Moderately harmful AA2 Chrysoperla carnea -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.07 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for etoxazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 1.09 A5 Rat (whole body) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.04 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) None allocated A5 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.03 A5 Dog, SF=100 -
Dermal penetration studies (%) 10 A3 default -
Dangerous Substances Directive 76/464 List II - -
Exposure Routes Public Risk low for consumers, bystanders and residents
Occupational Operator use of appropriate PPE/PPC is advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Possible liver toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification NL - Not listed
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for etoxazole

Language Name
English etoxazole
French etoxazole
German Etoxazol
Danish etoxazole
Italian etoxazole
Spanish etoxazol
Greek etoxazol
Slovenian etoksazol
Polish etoksazol
Swedish -
Hungarian -
Dutch etoxazol

Record last updated: Monday 04 November 2019
Contact: aeru@herts.ac.uk