Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!
fenazaquin (Ref: DE 436)
** XDE 436 ** XRD 562 ** EL-436 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for fenazaquin

Description: An acaricide active against citrus mites, red mites and other mites on fruit, nuts and ornamentals

Example pests controlled: Mites -Eutetranychus, panonychus, Tetranuchus

Example applications: Fruit including applies, pears, citrus; Nuts; Ornamentals

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1992, first reported; 1993, first introduced

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Germany/Poland
Date inclusion expires 31/05/2021
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C20H22N2O
Canonical SMILES CC(C)(C)C1=CC=C(C=C1)CCOC2=NC=NC3=CC=CC=C32
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) DMYHGDXADUDKCQ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C20H22N2O/c1-20(2,3)16-10-8-15(9-11-16)12-13-23-19-17-6-4-5-7-18(17)21-14-22-19/h4-11,14H,12-13H2,1-3H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Acaricide, Insecticide
Substance group Quinazoline
Minimum active substance purity 97.5
Known relevant impurities EU dossier - none declared
Substance origin Synthetic
Mode of action A mitochondrial electron transport inhibitor with contact action
CAS RN 120928-09-8
EC number 410-580-0
CIPAC number 693
US EPA chemical code 044501
PubChem CID 86356
Molecular mass (g mol-1) 306.40
PIN (Preferred Identification Name) 4-[2-(4-tert-butylphenyl)ethoxy]quinazoline
IUPAC name 4-tert-butylphenethyl quinazolin-4-yl ether
CAS name 4-(2-(4-(1,1-dimethylethyl)phenyl)ethoxy)quinazoline
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 21
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Tetranychus urticae
Physical state Colourless crystals
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Gowan
  • Pentagon Fine Chemicals
Example products using this active
  • Magister F
  • Pride Ultra
  • Turkoise
UK LERAP status None
Formulation and application details Usually supplied as a suspension concentrate that is diluted with water and applied as a spray.


ENVIRONMENTAL FATE

for fenazaquin

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.102 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 450000 C4 - Acetone -
75000 C4 - Methanol -
500000 C4 - Toluene -
600000 C4 - Dichloromethane -
Melting point (oC) 80.5 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 307 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 3.24 X 1005 Calculated -
Log P 5.51 A5 High
Bulk density (g ml-1)/Specific gravity 1.16 B5 -
Dissociation constant (pKa) at 25oC 2.44 A5 -
Note: Strong acid
Vapour pressure at 20oC (mPa) 1.90 X 10-02 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 5.71 X 10-02 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.63 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 215.8nm = 51500, 262.6nm = 12400 A5 -
Surface tension (mN m-1) 65.7 A5 at 20oC, 58u g l-1 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 45 B5 Moderately persistent
DT50 (lab at 20oC) 54.0 A5 Moderately persistent
DT50 (field) 30.5 A5 Moderately persistent
DT90 (lab at 20oC) 270 A5 -
DT90 (field) 101.3 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 50-117.5 days, DT90 range 184-299 days, field studies DT50 range 12.9-43.6 days, DT90 range 42.7-160 days; Other studies lab DT50 range 67-115 days, field range 16-22 days (B4)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 3.1 R4 -
Note Published literature RL50 range 1.8-3.8 days, 3 field crops, various matrices, n=3
Aqueous photolysis DT50 (days) at pH 7 Value 15 A5 Slow
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 130 A5 Persistent
Note pH sensitive: DT50 9.6 days at pH 5, 219 days at pH 9 all at 25 degC
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 247 A5 Non-mobile
Kfoc 26499
1/n 0.899
Notes and range EU dossier Kf range 54-512 mL/g, Kfoc range 16020-42695 mL/g, 1/n range 0.887-0.917, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
4-hydroxyquinazoline This metabolite may cause environmental pollution, click here for further information Soil (photolysis)   0.360   Major fraction, Relevant
4-tert-butylphenylethyl alcohol This metabolite may cause environmental pollution, click here for further information Soil   0.179   Major fraction, Relevant
2-oxyfenazaquin This metabolite may cause environmental pollution, click here for further information Soil   0.139   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
4-(2-hydroxy-1,1dimethylethyl)phenylacetic acid fenazaquin AN-1 Rat (Urinary) - -
2,2-dimethyl-2-(4-((4-quinazolinyl)oxy)-1-hydroxyethyl)phenyl ethanol fenazaquin F-1A Rat (Faecal) - -
2,2-dimethyl-2-(4-((4-quinazolinyl)oxy)ethyl)phenyl ethanol fenazaquin F-1 Rat (Faecal); Plant (Grapes) - -
2,2-dimethyl-2-(4-((2-((6-hydroxy-4-quinazolinyl)oxy)ethyl)phenyl acetic acid fenazaquin F-3; fenazquin M29 Rat (Faecal); Animal - -


ECOTOXICOLOGY

for fenazaquin

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 699 A5 Threshold for concern
CT50 (days) 98% 14days -
Mammals - Acute oral LD50 (mg kg-1) 134 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) > 10 B5 Rat High
(ppm diet) > 150 -
Birds - Acute LD50 (mg kg-1) 1747 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) > 1169 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.0038 A5 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) 0.00096 A5 Oncorhynchus mykiss High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0041 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0021 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.16 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants > 897 A4 range of tested species
Seedling emergence, ER50
as g/ha
-
> 897 A4 range of tested species
Vegetative vigour, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) > 0.208 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 1.21 A5 Moderate
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 4.29 A5 Moderate
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 13.25 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) 0.6 A5 Eisenia foetida, 56 days corr Moderate
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) 125 A5 Folsomia candida, 28d -
Other arthropod (1) LR50 g ha-1 2.0 <
A5 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 187.25 A5 Aphidius rhopalosiphi -
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.75 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for fenazaquin

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 134 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 1.9 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.005 A4 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A4 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.01 A4 Dog, SF=100 -
Dermal penetration studies (%) 2-14 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Acceptable for the registered uses
Occupational Acceptable for the registered uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A1; B3; C3; D0; E0

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Moderately toxic
Harmful by inhalation
Possible liver toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H301, H332
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R25
Xn - Harmful: R20
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S37, S45, S60, S61
WHO Classification II - Moderately hazardous
UN Number 2588 for active, products usually 2811
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for fenazaquin

Language Name
English fenazaquin
French fenazaquin
German Fenazaquin
Danish fenazaquin
Italian fenazaquin
Spanish fenazaquin
Greek -
Slovenian fenazakvin
Polish fenazachina
Swedish -
Hungarian fanarquin
Dutch -

Record last updated: Saturday 02 November 2019
Contact: aeru@herts.ac.uk