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mefentrifluconazole (Ref: BAS 750F)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Mefentrifluconazole is a relatively new conazole fungicide used to control disease on cereals. It has a low aquesous solubility, low volatility and, based on its its chemical properties, it would not be expected to leach to groundwater. However, it may peersist in some soil systems. Mefentrifluconazole has a low mamalian toxicity. No significant health effects have been identified but it may be a skin sensitiser. It demonstrates a moderate level of toxicity to most species, the main exception is honeybees where the txicity is low.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for mefentrifluconazole

Description: A novel conazole fungicide

Example pests controlled: Septoria tritici

Example applications: Cereals

Efficacy & activity: Shown to be effective for its proposed uses in experimental trials.

Availability status: Current

Introduction & key dates: -

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK/France & Austria
Date inclusion expires 20/03/2029
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C18H15ClF3N3O2
Canonical SMILES CC(CN1C=NC=N1)(C2=C(C=C(C=C2)OC3=CC=C(C=C3)Cl)C(F)(F)F)O
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) JERZEQUMJNCPRJ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C18H15ClF3N3O2/c1-17(26,9-25-11-23-10-24-25)15-7-6-14(8-16(15)18(20,21)22)27-13-4-2-12(19)3-5-13/h2-8,10-11,26H,9H2,1H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Conazole
Minimum active substance purity 970 g/kg
Known relevant impurities EU 2017 dossier: dimethylformamide max: 0.5 g/kg
Substance origin Synthetic
Mode of action A sterol biosynthesis inhibitor
CAS RN 1417782-03-6
EC number None allocated
CIPAC number -
US EPA chemical code -
PubChem CID 71230671
Molecular mass (g mol-1) 397.78
PIN (Preferred Identification Name) rac-(2R)-2-(4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol
IUPAC name (2RS)-2-(4-(4-chlorophenoxy)-α,α,α-trifluoro-o-tolyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol
CAS name α-(4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl)-a-methyl-1H-1,2,4-triazole-1-ethanol
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) -
Examples of recorded resistance -
Physical state White crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
Example products using this active
  • Revysol
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as an emulsifiable concentrate and used as a foliar spray.


ENVIRONMENTAL FATE

for mefentrifluconazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.81 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 93200 A5 - Acetone -
116200 A5 - Ethyl acetate -
8500 A5 - Xylene -
55300 A5 - 1,2-Dichloroethane -
Melting point (oC) 126 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 300 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.51 X 1003 Calculated -
Log P 3.4 A5 High
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC 3.0 A4 - Calculated -
Note:
Vapour pressure at 20oC (mPa) 3.2 X 10-03 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.6 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.12 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.45 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 at pH 6.1: 202nm=37761; at pH 6.4: 194nm=54636; at pH 1.4: 199nm=43245, at pH 12.2: 231nm=16668 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 268 A5 Persistent
DT50 (lab at 20oC) 268 A5 Persistent
DT50 (field) 200 A5 Persistent
DT90 (lab at 20oC) 1000 A5 -
DT90 (field) 891 A5 -
DT50 modelling endpoint 846.6 A5 Actual measured max aerobic conditions, EU locations -
Note EU 2017 dossier Lab studies: DT50 range 104-477 days, DT90 >1000 days, Soils=5; Field studies DT50 range 96.5-611 days, DT90 range 616->1000 days, Soils=6
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) 163.2 A5 Slow
Water phase only DT50 (days) 7.2 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 39.93 A5 Slightly mobile
Kfoc 3456
1/n 0.975
Notes and range EU 2017 dossier Kf range 24.53-126.14 mL/g, Kfoc range 2010-4931 mL/g, 1/n range 0.92-1.02, Soils=8
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
1,2,4-triazole (Ref: CGA 71019) Soil   0.051   Minor fraction; Relevant


ECOTOXICOLOGY

for mefentrifluconazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 816 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.532 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.944 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.016 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 1.30 A5 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) > 97.0 A5 Chironomus dilutus, 10day Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) > 1.158 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 2.02 A5 Lemna gibba, growth Moderate
Non-target plants > 1.5 A5 across all tested species incl. lettuce, tomato, cabbage, soybean, wheat
Vegetative vigour, ER50
as L product/ha
-
> 1.5 A5 across all tested species incl. lettuce, tomato, cabbage, soybean, wheat
Seedling emergence, ER50
as L product/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 1.352 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.103 A5 Pseudokirchneriella subcapitata, 72hr Moderate
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Apis mellifera Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Apis mellifera Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 200 A5 Bombus terrestris Low
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 195.4 A5 Bombus terrestris Low
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 769 A5 Typhlodromus pyri, as product -
% Effect - - -
Other arthropod (2) LR50 g ha-1 95.4 A5 Aphidius rhopalosiphi, as product -
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2.53 mg kg-1 soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for mefentrifluconazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.31 A5 Rat, (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.04 A5 Mice, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.25 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.11 A5 rabbit, SF=100 -
Dermal penetration studies (%) 4 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Acceptable risk for the proposed uses
Occupational Acceptable risk for the proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E3

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Potential liver toxicant
May cause an allergic skin reaction
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H317
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases -
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for mefentrifluconazole

Language Name
English mefentrifluconazole
French mefentrifluconazole
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Friday 03 May 2019
Contact: aeru@herts.ac.uk