(S)-hexaconazole
Last updated: 22/01/2023
(Also known as: (+) hexaconazole)
Little data is available for this specific isomer but is available for the isomer mixture. Hexaconazole is a fungicide used to control powdery mildew, scabs and rusts. It has a low aqueous solubility and a low viscosity. It tends to be environmentally persistent in both soil and aquatic systrems. It is moderately toxic to birds, fish, aquatic invertebrates, algae and earthworms but has a low toxicity to honeybees. It has a low mammalian toxicity and no information on other health issues has been identified although it my be a skin and eye irritant
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
An isomer of the conazole (imidazole) fungicide used to control both seed-borne and soil-borne diseases especially Ascomycetes and Basidiomycetes spp.
Powdery mildew, Scabs, Rusts
Vines; Apples; Pears,; Bananas; Vegetables; Some small grain cereals
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Current
1986
Not approved
Not applicable
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not approved
Italy
Not applicable
Not applicable
Yes as hexaconazole
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
(S)-hexaconazole is the S-isomer of chiral hexaconazole
C₁₄H₁₇Cl₂N₃O
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Yes
Fungicide, Other substance
Wood preservative
Triazole fungicide
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Synthetic
Broad spectrum, systemic with protective and curative action. Disrupts membrane function. Sterol biosynthesis inhibitor.
221627-82-3
No data found
465
128925
37888329
613-171-00-7
314.21
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(S)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol
α-butyl-α-(2,4-dichlorophenyl)-1H-1,2,4-triazole-1-ethanol
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Not applicable
Not applicable
Not applicable
3
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White crystalline solid
Passport Manage Anvil Planete Aster
Available in a variety of formulations including oil miscible liquids, soluble grains and suspension concentrates.
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Likely to be soluble
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Bssed on chemical group
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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3.0
R4 R = Peer reviewed scientific publications 4 = Verified data
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Published literature data range 2.0-4.4 days, 4 field & glasshouse crops, various matrices, n=4
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Soil adsorption and mobility
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Cannot be calculated
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None
Terrestrial ecotoxicology
2189
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source
Rat as isomer mix
Low
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> 4000
L2 L = Pesticide manuals and hard copy reference books / other sources 2 = Unverified data of unknown source
Anas platyrhynchos as the isomer mix
Low
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3.4
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Oncorhynchus mykiss as the isomer mix
Moderate
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> 2.9
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source
Daphnia magna as the isomer mix
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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2189
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source
Rat as isomer mix
Low
2000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat as the isomer mix
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EU MRL pesticide database 
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Carcinogen
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
✓Yes, known to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
USEPA - possible human carcinogen Endocrine issues - Inhibition of aromatase activity, decrease of the estrogens production
No information available
Health: H302, H317 Environment: H411
III (Slightly hazardous)
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(S)-hexaconazole
(S)-hexaconazole
(S)-Hexaconazol
(S)-hexaconazol
(S)-esaconozolo
(S)-hexaconazol
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(S)-heksakonazol
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(S)-hexakonazol
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Record last updated:
22/01/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242