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Fluazaindolizine (Ref: DPX-Q8U80)
Last updated: 22/10/2023
(Also known as: Q8U80)

SUMMARY
Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
High alert:
GUS: High leachability
Ecotoxicity
Moderate alert:
Birds chronic ecotoxicity: Moderate; Fish acute ecotoxicity: Moderate; Fish chronic ecotoxicity: Moderate; Bees acute oral ecotoxicity: Moderate; Earthworms chronic ecotoxicity: Moderate
Human health
Moderate alert:
Mammals acute toxicity: Moderate; Reproduction/development effects
GENERAL INFORMATION
Description
A selective nematicide for the control of plant parasitic nematodes in both the field and in protected cropping
Example pests controlled
Root-knot nematode (Meloidogyne incognita)
Example applications
Tomato; Cucubits: cucumber, courgette; Aubergine; Pepper; Strawberry; Potato; Root & tuber vegetables including carrots
Efficacy & activity
Efficacy demonstrated in extensive field trials
Availability status
Novel
Introduction & key dates
-
UK regulatory status
UK COPR regulatory status
Not applicable
Date COPR inclusion expires
Not applicable
UK LERAP status
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Pending
Dossier rapporteur/co-rapporteur
Malta
Date EC 1107/2009 inclusion expires
Not applicable
EU Candidate for substitution (CfS)
Not applicable
Listed in EU database
No
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
                 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
                 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
                 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
                 
Additional information
Also used in
-
Chemical structure
Isomerism
None. Fluazaindolizine is not a chiral molecule
Chemical formula
C₁₆H₁₀Cl₂F₃N₃O₄S
Canonical SMILES
COC1=CC(=C(C=C1)Cl)S(=O)(=O)NC(=O)C2=CN3C=C(C=C(C3=N2)Cl)C(F)(F)F
Isomeric SMILES
-
International Chemical Identifier key (InChIKey)
PHCCDUCBMCYSNQ-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C16H10Cl2F3N3O4S/c1-28-9-2-3-10(17)13(5-9)29(26,27)23-15(25)12-7-24-6-8(16(19,20)21)4-11(18)14(24)22-12/h2-7H,1H3,(H,23,25)
2D structure diagram/image available?
Yes
General status
Pesticide type
Nematicide, Insecticide
Substance groups
Imidazopyridine nematicide; Pyridine nematicide; Sulfonamide nematicide
Minimum active substance purity
961 g kg⁻¹
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Selective
CAS RN
1254304-22-7
EC number
832-861-0
CIPAC number
986
US EPA chemical code
-
PubChem CID
-
CLP index number
No data found
Molecular mass
468.24
PIN (Preferred Identification Name)
8-chloro-N-(2-chloro-5-methoxybenzene-1-sulfonyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide
IUPAC name
8-chloro-N-((2-chloro-5-methoxyphenyl)sulfonyl)-6-(trifluoromethyl)imidazo(1,2-a)pyridine-2-carboxamide
CAS name
8-chloro-N-((2-chloro-5-methoxyphenyl)sulfonyl)-6-(trifluoromethyl)imidazo(1,2-a)pyridine-2-carboxamide
Other status information
-
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Class (HRAC MoA class)
Not applicable
Herbicide Resistance Class (WSSA MoA class)
Not applicable
Insecticide Resistance Class (IRAC MoA class)
Not known
Fungicide Resistance Class (FRAC MOA class)
Not applicable
Examples of recorded resistance
-
Physical state
-
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • Corteva AgriScience
Example products using this active
  • Salibro
  • Reklemel Active
Formulation and application details
-
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
2148
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
High
Solubility - In organic solvents at 20 °C (mg l⁻¹)
35050
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Acetonitrile
-
3470
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Methanol
-
99760
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Acetone
-
27620
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Ethyl acetate
-
Melting point (°C)
218.5
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Boiling point (°C)
Decomposes before boiling
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Degradation point (°C)
260
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
6.92 X 10-01 Calculated -
Log P
-0.16
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Low
Fat solubility of residues
Solubility
- - -
Data type
- - -
Density (g ml⁻¹)
- - -
Dissociation constant pKa) at 25 °C
5.60
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
-
Vapour pressure at 20 °C (mPa)
- - -
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
- - -
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
202nm=48000; 235nm=50000, 298nm=6500 at pH 1.8, 7.0 & 10.5
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
-
Surface tension (mN m⁻¹)
- - -
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
Not readily biodegradable
Soil degradation (days) (aerobic)
DT₅₀ (typical)
31.8
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderately persistent
DT₅₀ (lab at 20 °C)
31.8
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderately persistent
DT₅₀ (field)
31.95
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderately persistent
DT₉₀ (lab at 20 °C)
330.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Persistent
DT₉₀ (field)
217.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
DT₅₀ modelling endpoint
46.8
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
(normalised geometric mean)
-
Note
EU 2023 dossier Lab studies DT₅₀ (normalised) range 3.9-241.3 days; DT₉₀ (measured) 19.0-1000 days; Soils=13; Field data DT₅₀ (measured) range 3.8-79.8 days; DT₉₀ (measured) range 24.2-498.0 days, Soils=12
Dissipation rate RL₅₀ on plant matrix
Value
- - -
Note
-
Dissipation rate RL₅₀ on and in plant matrix
Value
- - -
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
- - -
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
Stable
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Stable
Note
Stable at all environmentally relevant pH values
Water-sediment DT₅₀ (days)
32.5
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderately fast
Water phase only DT₅₀ (days)
30.3
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Stable
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
3.1
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Moderately mobile
Koc
198.4
Notes and range
EU 2023 dossier kd range 1.42-4.61 mL g⁻¹; Koc range 148-254 mL g⁻¹, Soils=5
Freundlich
Kf
1.81
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderately mobile
Kfoc
124.8
1/n
0.855
Notes and range
EU 2023 dossier kf range 0.94-2.84 mL g⁻¹; Kfoc range 91.5-168 mL g⁻¹, 1/n range 0.833-0.884, Soils=5
pH sensitivity
None
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
2.86 Calculated High leachability
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
2.27 X 10-01 Calculated -
Note
-
Potential for particle bound transport index
Low Calculated -
Potential for loss via drain flow
Moderately mobile Calculated -
Bio-concentration factor
BCF (l kg⁻¹)
- - -
CT₅₀ (days)
- -
Known soil metabolites
Metabolite
Major/Minor fraction
Estimated maximum occurrence fraction
Notes
2-chloro-5-hydroxybenzenesulfonamide (Ref: IN-A5760)
Major fraction 0.055 -
2-chloro-5-methoxybenzenesulfonamide (Ref: IN-F4106)
Major fraction 0.860 -
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid (Ref: IN-QEK31)
Major fraction 0.790 -
8-chloro-N-[(2-chloro-5-hydroxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-REG72)
Minor fraction 0.038 -
3-chloro-5-(trifluoromethyl)pyridin-2-amine (Ref: IN-VM862)
Major fraction 0.199 -
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-RYC33)
Minor fraction - -
Known groundwater metabolites
Metabolite
EC SANCO/221/2000 relevancy
ADI (mg kg⁻¹ bodyweight day⁻¹)
WHO drinking water guidance value (μg L⁻¹ day⁻¹)
2-chloro-5-hydroxybenzenesulfonamide (Ref: IN-A5760)
Not relevant 0.3 1800
2-chloro-5-methoxybenzenesulfonamide (Ref: IN-F4106)
Not relevant 0.3 1800
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid (Ref: INQEK31)
Not relevant 0.3 1800
3-chloro-5-(trifluoromethyl)pyridin-2-amine (Ref: IN-VM862)
Not relevant 0.02 1200
Other known metabolites
Metabolite name and reference
Aliases
Formation medium / Rate
Estimated maximum occurrence fraction
Metabolising enzymes
2-chloro-5-hydroxybenzenesulfonamide (Ref: IN-A5760) - Plant; Animal; Rat - -
2-chloro-5-methoxybenzenesulfonamide (Ref: IN-F4106) - Water/sediment systems; Plant; Animal; Rat/Mouse - -
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid (Ref: IN-QEK31) - Water/sediment systems; Plant; Animal; Rat/Mouse - -
3-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]-L-alanine hydrochloride (Ref: IN-QZY47) - Plant - -
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid methyl ester (Ref: IN-R2W56) - Plant; Animal - -
2-chloro-5-(beta-D-glucopyranosyloxy) (Ref: IN-R3Z85) - Plant - -
5-(trifluoromethyl)pyridin-2-amine (Ref: IN-R6P21) - Surface water (aqueous hydrolysis) - -
8-chloro-N-[(2-chloro-5-hydroxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-REG72) - Water/sediment systems; Plant; Animal; Rat/Mouse - -
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-RYC33) - Plant; Animal; Rat - -
3-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]-(2R)-hydroxypropanoic acid, potassium salt (Ref: IN-TMQ01)
Note: R-enantiomer of IN-RSU03
- Plant - -
3-[[(2-chloro-5-hydroxyphenyl)sulfonyl]amino]-(2R)-hydroxypropanoic acid potassium salt (Ref: IN-TQD54)
Note: R-enantiomer of IN-UNS90
- Plant - -
N-(carboxyacetyl)-3-[[(2-chloro-5methoxyphenyl)sulfonyl]-amino]-L-alanine (Ref: IN-TUT81) - Plant - -
beta-D-glucopyranose 1-[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate] (Ref: IN-UGA20) - Plant - -
4-[4-[[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]carbonyl]-1H-imidazol-2-yl]-4-oxo-2-(trifluoromethyl)-(2E/Z)-butenoic acid (Ref: IN-UGA22)
Note: Unstable in water
- Surface water (aqueous photolysis) - -
4-[[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]carbonyl]-1H-imidazole-2-carboxylic acid (Ref: IN-UGA26) - Surface water (aqueous photolysis) - -
N-[(2-chloro-5-methoxyphenyl)sulfonyl]-1H-imidazole-4-carboxamide (Ref: IN-UHC58) - Surface water (aqueous photolysis) - -
[(2S,3R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]1-[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate] (Ref: IN-UHD13) - Plant - -
8-chloro-N-[(2-chloro-hydroxy-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-UHD20) - Rat/Mouse - -
8-chloro-N-[(2-chloro-4,5-dihydroxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-UHD21) - Rat/Mouse - -
3-[[(2-chloro-5-hydroxyphenyl)sulfonyl]amino]-L-alanine hydrochloride (Ref: IN-UJV12)
Note: S-enantiomer
- Plant - -
2-[[[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl]oxy]butanedioic acid (Ref: IN-UJU44) - Plant - -
N-[(2-chloro-5-methoxyphenyl)sulfonyl]-8-hydroxy-6-(trifluoromethyl)- imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-URA40) - Surface water (aqueous photolysis) - -
3-chloro-5-(trifluoromethyl)pyridin-2-amine (Ref: IN-VM862) - Sediments; Surface water (aqueous photolysis); Plants - -
N-[[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl]carbonyl]-L-glutamic acid (Ref: IN-WUK12) - Plant - -
2-chloro-5-(beta-L2-glucopyranuronosyloxy)benzenesulfonamide - Animal - -
2-chloro-5-(sulfooxy)benzenesulfonamide - Animal; Rat/Mouse - -
2-chloro-4-(beta-L-Lglucopyranuronosyloxy)-benzenesulfonamide - Rat (bile) - -
8-chloro-N-[(2-chloro-5-(beta-D-glucopyranosyl) phenyl) sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide - Plant - -
8-chloro-N-[[2-chloro-5-(sulfooxy)phenyl]sulfonyl]-6-(trifluoromethyl) imidazo[1,2-a]pyridine-2-carboxamide - Rat (bile) - -
3-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]-(2R)-(beta-D-glucopyranosyloxy)propanoic acid - Plant - -
mono[1-carboxy-(2R)-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]ethyl]-propanedioic acid ester - Plant - -
(2R)-[[6-O-(2-carboxyacetyl)-beta-D-glucopyranosyl]oxy]-3-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]-propanoic acid - Plant - -
8-hydroxy-6-(trifluoromethyl)- imidazo[1,2-a]pyridine-2-carboxamide - Surface water (aqueous photolysis) - -
3-[[[2-chloro-5-(beta-D-glucopyranosyloxy)phenyl]sulfonyl]-amino]-(2R)-hydroxypropanoic acid - Plant - -
imidazo[1,2-a]pyridine-2-carboxylic acid, 8-chloro-6-(trifluoromethyl)-, 3-(hexopyranuronosyloxy)-2-hydroxypropyl ester - Plant - -
N-acetyl-3-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]-L-alanine - Plant; Rat - -
N-acetyl-3-[[(2-chloro-5-hydroxyphenyl)sulfonyl]amino]-L-alanine - Rat - -
N-acetyl-3-[[[2-chloro-5-(sulfooxy)phenyl]sulfonyl]-amino]-L-alanine - Rat - -
2-chloro-4-hydroxy-5-(sulfooxy)-benzenesulfonamide - Rat - -
ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
940
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
Moderate
Mammals - Short term dietary NOEL
(mg kg⁻¹)
- - -
(ppm diet)
- -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
- - -
Birds - Acute LD₅₀ (mg kg⁻¹)
> 2250
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Colinus virginianus
Low
Birds - Short term dietary (LC₅₀/LD₅₀)
- - -
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
51.1
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Colinus virginianus as NOEC
Moderate
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
> 1000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Eisenia foetida
Low
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
100
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Eisenia foetida
Moderate
Soil micro-organisms
Nitrogen transformation: No significant adverse effect
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes

% effect day 28 onwards
-
Collembola
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
500
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Folsomia candida
-
Non-target plants
- - -
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 200
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Apis mellifera
Low
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 19.62
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Apis mellifera
Moderate
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Chronic
- - -
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 200
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Bombus terrestris
Low
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 176
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Bombus terrestris
Low
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other bee species (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other bee species (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Beneficial insects (Ladybirds)
- - -
Beneficial insects (Lacewings)
- - -
Beneficial insects (Parasitic wasps) as mL product (500g l⁻¹)/ha
> 2000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Aphidius rhopalosiphi
-
Beneficial insects (Predatory mites) as mL product (500 g l⁻¹)/ha
> 2000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Typhlodromus pyri
-
Beneficial insects (Ground beetles)
- - -
Aquatic ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
> 30.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Cyprinodon variegatus
Moderate
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)
0.75
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Cyprinodon variegatus
Moderate
Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
> 120
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Daphnia magna
Low
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
- - -
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
> 30
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Americamysis bahia
Moderate
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
> 120
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Chironomus riparius
Low
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
35.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Chironomus riparius
Low
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
37.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Chironomus riparius
Moderate
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
28.5
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Lemna gibba
Low
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
46.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Pseudokirchneriella subcapitata
Low
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
940
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
Moderate
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
2000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
-
Mammals - Inhalation LC₅₀ (mg l⁻¹)
> 5.3
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat (nose only) 4 hr
-
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.3
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat SF=100
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
1.25
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat SF=100
-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
0.64
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat SF=100
-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
0.15
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat SF=100
-
Dermal penetration studies (%)
1.7-13.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
concentration dependent
-
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
Negligible exposure expected for bystanders, consumers and the general public
Occupational
Negligible exposure expected for operators
MRLs
European
EU MRL pesticide database 
Great Britain
GB MRL Register 
Notes
-
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Mammalian dose elimination route and rate
Majority (>90%) of administered dose excreted in urine and feces over 48 hours. Metabolised in humans.
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database)
0 = No data
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source)
3 = Negative
XNo, known not to cause a problem
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
?Possibly, status not identified
No data found
XNo, known not to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
No data found
XNo, known not to cause a problem
XNo, known not to cause a problem
Eye irritant Phototoxicant  
XNo, known not to cause a problem
Yes, known to cause a problem
 
General human health issues
Possible kidney, gall bladder, liver toxicant
Handling issues
Property
Value and interpretation
General
Not expected to auto-ignite; Not highly flammable; Melts rather than combusts
Not explosive or oxidising
CLP classification 2013
Health: H373, H302
Environment: H411
WHO Classification
Not listed (Not listed)
UN Number
-
Waste disposal & packaging
-
Shelf-life, storage, stability and reactivity
-
TRANSLATIONS
Language
Name
English
fluazaindolizine
French
fluazaindolizine
German
-
Danish
-
Italian
-
Spanish
-
Greek
-
Polish
-
Swedish
-
Hungarian
-
Dutch
-
Norwegian
-

Record last updated: 22/10/2023
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242