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flazasulfuron (Ref: OK 1166)
** SL 160 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for flazasulfuron

Description: A pre- and post-emergence selective herbicide used to control a wide range of annual and perennial weeds

Example pests controlled: Grasses, Broad-leaved weeds, Sedges

Example applications: Turf; Citrus; Grapes; Olives; Sugarcane; Non-cropped areas

Efficacy & activity: Efficacy has been scientifically donstrated. Many crops show very good tolerance as long as green parts are not exposed.

Availability status: Current

Introduction & key dates: 1989, Japan

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Spain/France
Date inclusion expires 31/01/2032
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: South Africa, Brazil, Colombia, Mexico, Japan, Taiwan

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None
Chemical formula C13H12F3N5O5S
Canonical SMILES COC1=CC(=NC(=N1)NC(=O)NS(=O)(=O)C2=C(C=CC=N2)C(F)(F)F)OC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) HWATZEJQIXKWQS-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C13H12F3N5O5S/c1-25-8-6-9(26-2)19-11(18-8)20-12(22)21-27(23,24)10-7(13(14,15)16)4-3-5-17-10/h3-6H,1-2H3,(H2,18,19,20,21,22)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Sulfonylurea
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic, absorbed through leaves. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS
CAS RN 104040-78-0
EC number -
CIPAC number 595
US EPA chemical code 119011
PubChem CID 93539
Molecular mass (g mol-1) 407.37
PIN (Preferred Identification Name) N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-3-(trifluoromethyl)pyridine-2-sulfonamide
IUPAC name 1-(4,6-dimethoxypyrimidin-2-yl)-3-(3-trifluoromethyl-2-pyridylsulfonyl)urea
CAS name N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-3-(trifluoromethyl)-2-pyridinesulfonamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) B
Herbicide Resistance Classification (WSSA) 2
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • ISK Biosciences
  • Ishihara Sangyo Kaisha Ltd.
  • Belchim
Example products using this active
  • Mission
  • Aikido
  • Chikara
  • Epsilon
  • Katana
  • Paradise
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Usually supplied as a wettable powder.


ENVIRONMENTAL FATE

for flazasulfuron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 2100 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 0.5 A5 - n-Hexane -
560 A5 - Toluene -
22100 A5 - Dichloromethane -
6900 A5 - Ethyl acetate -
Melting point (oC) 180 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 181.5 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 8.71 X 10-01 Calculated -
Log P -0.06 A5 Low
Bulk density (g ml-1)/Specific gravity 1.62 A5 -
Dissociation constant (pKa) at 25oC 4.37 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 0.0133 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.58 X 10-06 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.55 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.32 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 241.0nm = 17300 A4 -
Surface tension (mN m-1) 70.5 A5 at 20 degC, 100% -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 41.2 A5 Moderately persistent
DT50 (lab at 20oC) 41.2 A5 Moderately persistent
DT50 (field) 10 A5 Non-persistent
DT90 (lab at 20oC) 162.3 A5 -
DT90 (field) 45 A5 -
DT50 modelling endpoint - - -
Note EU 2016 dossier lab studies DT50 range 7.65-102.1 days, DT90 range 55.5-339.3 days, field studies DT50 range 2-18 days, DT90 range 10-100 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 11 A5 Non-persistent
Note pH sensitive: DT50 0.5 days at pH 4, 2.6 days at pH 5, 8.8 days at pH 9, all at 25 degC
Water-sediment DT50 (days) 23 A5 Fast
Water phase only DT50 (days) 15 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - A4 Mobile
Koc 46.2
Notes and range EU dossier Koc range 32.4-80.9 mL/g, Soils=4
Freundlich Kf 4.79 A5 Moderately mobile
Kfoc 283.3
1/n 0.844
Notes and range EU 2016 dossier Kf range 1.87-8.45 mL/g, Kfoc range 59-768 mL/g, 1/n range 0.80-0.87, Soils=4
pH sensitivity Yes

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
1-(4,6-dimethoxypyrimidin-2-yl)-1-(3-trifluoromethyl-2-pyridyl)urea This metabolite may cause environmental pollution, click here for further information Soil   0.663   Major fraction, Relevant
3-trifluoromethyl-2-pyridylsulfonamide This metabolite may cause environmental pollution, click here for further information Soil   0.260   Major fraction, Relevant
4,6-dimethoxy-N-(3-(trifluoromethyl)pyridin-2-yl)pyrimidin-2-amine This metabolite may cause environmental pollution, click here for further information Soil   0.478   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
4,6-dimethoxy-2-pyrimidinamine
Note: Oral LD50(rat) = 737mg kg-1
ADMP Mammal; Plant; Soil; groundwater - -
6-Methoxy-2-{[3-(trifluoromethyl)pyridin-2-yl]amino}pyrimidin-4-ol HTPP Water; Sediment; Soil - -
1-(4,6-Dimethoxypyrimidin-2-yl)urea DMPU Mammal; Plant; Soil (photolysis); Surface water; groundwater - -
N-[(4-Methoxy-6-oxo-1,6-dihydropyrimidin-2-yl)carbamoyl]-3-(trifluoromethyl)pyridine-2-sulfonamide HMTU Groundwater; Mammal; Soil - -
1-(4-Hydroxy-6-methoxypyrimidin-2-yl)-1-[3-(trifluoromethyl)pyridin-2-yl]urea HTPU Mammal; Soil; Surface water - -
3-(Trifluoromethyl)pyridin-2(1H)-one HTF Groundwater; Soil (photolysis); Surface water; Groundwater - -


ECOTOXICOLOGY

for flazasulfuron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 11.7 A5 Rat High
(ppm diet) 200 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5620 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 22 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 5 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 25 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 6.25 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.1 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.00004 A4 Lemna gibba, 7 day High
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.014 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.005 A5 Pseudokirchneriella subcapitata Moderate
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Apis mellifera Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Apis mellifera Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 R3 Bombus terrestris Low
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 97.5 R3 Bombus terrestris Moderate
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 15.75 A5 Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) 8.0 A5 Eisenia foetida Moderate
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) 125 A5 Folsomia candida, 28d -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 0 Mortality
Reproduction
Dose: 0.05 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 11 Beneficial capacity
Dose: 0.02 kg ha-1
A5 Typhlodromus pyri, adult
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 10 x field rate
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for flazasulfuron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.99 A5 Rat, 4 hr (whole body) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.013 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.02 A4 Dog, 1 year, SF=100 -
Dermal penetration studies (%) 10.0 A5 -
Dangerous Substances Directive 76/464 List II - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A0; B0; C0; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Possible Liver, kidney & blood toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification NL - Not listed
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for flazasulfuron

Language Name
English flazasulfuron
French flazasulfuron
German Flazasulfuron
Danish flazasulfuron
Italian flazasulfuron
Spanish flazasulfuron
Greek -
Slovenian flazasulfuron
Polish flazasulfuron
Swedish -
Hungarian flazaszulfuron
Dutch flazasulfuron

Record last updated: Monday 04 November 2019
Contact: aeru@herts.ac.uk