Top Environmental Fate Ecotoxicology Human Health Translations
Home
A to Z: All
A to Z: Insecticides
A to Z: Herbicides
A to Z: Fungicides
A to Z: Other related substances
Search
Support information
Edit history
Purchasing and licensing
NEW
Industry collaboration
Florylpicoxamid (Ref: X12485659)
Last updated: 26/04/2024
(Also known as: XDE 659; XR-659)

SUMMARY
Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
Moderate alert:
Drainflow: Slightly mobile; Potential for particle bound transport: Medium
Ecotoxicity
High alert:
Fish acute ecotoxicity: High; Daphnia acute ecotoxicity: High; Earthworms acute ecotoxicity: High
Human health
Moderate alert:
Possible Carcinogen; Reproduction/development effects
GENERAL INFORMATION
Description
A 'green chemistry' fungicide derived from renewable raw materials which offers curative and protectant disease control of a wide range of pathogens in multiple crops
Example pests controlled
Septoria spp, Powdery Mildews, Botrytis spp, Anthracnose, Alternaria, Scab, Monilinia and others
Example applications
Cereals; Vines; Fruits; Nuts; Vegetables; Oilseed rape; Sugarbeet; Lentils; Ornamentals
Efficacy & activity
Efficacy and crop safety was assessed in various places including Australi and new Zealand
Availability status
Novel
Introduction & key dates
2019, introduced
UK regulatory status
UK COPR regulatory status
Not approved
Date COPR inclusion expires
Not applicable
UK LERAP status
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Pending
Dossier rapporteur/co-rapporteur
Denmark
Date EC 1107/2009 inclusion expires
Not applicable
EU Candidate for substitution (CfS)
No
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
                 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
                 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
                 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
                 
Additional information
Also used in
Australia; USA; Canada; South Korea
Chemical structure
Isomerism
Isomeric but purposely developed as a single stereoisomer
Chemical formula
C₂₇H₂₆F₂N₂O₆
Canonical SMILES
CC(C(C1=CC=C(C=C1)F)C2=CC=C(C=C2)F)OC(=O)C(C)NC(=O)C3=NC=CC(=C3OC(=O)C)OC
Isomeric SMILES
C[C@@H](C(C1=CC=C(C=C1)F)C2=CC=C(C=C2)F)OC(=O)[C@H](C)NC(=O)C3=NC=CC(=C3OC(=O)C)OC
International Chemical Identifier key (InChIKey)
ATZHVIVDMUCBEY-HOTGVXAUSA-N
International Chemical Identifier (InChI)
InChI=1S/C27H26F2N2O6/c1-15(31-26(33)24-25(37-17(3)32)22(35-4)13-14-30-24)27(34)36-16(2)23(18-5-9-20(28)10-6-18)19-7-11-21(29)12-8-19/h5-16,23H,1-4H3,(H,31,33)/t15-,16-/m0/s1
2D structure diagram/image available?
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name Relationship Link
florylpicoxamid -
General status
Pesticide type
Fungicide, Bactericide
Substance groups
Picolinamide fungicide
Minimum active substance purity
>98%
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Broad spectrum. Substance is a quinone inside inhibitor (QiI) causing disruption of the fungal mitochondrial electron transport system complex III.
CAS RN
1961312-55-9
EC number
No data found
CIPAC number
None allocated
US EPA chemical code
-
PubChem CID
-
CLP index number
No data found
Molecular mass
512.51
PIN (Preferred Identification Name)
(1S)-2,2-bis(4-fluorophenyl)-1-methylethyl N-[(3-acetoxy-4-methoxy-2-pyridyl)carbonyl]-L-alaninate
IUPAC name
(1S)-2,2-bis(4-fluorophenyl)-1-methylethyl N-[(3-acetoxy-4-methoxy-2-pyridyl)carbonyl]-L-alaninate
CAS name
(1S)-2,2-bis(4-fluorophenyl)-1-methylethyl N-[[3-(acetyloxy)-4-methoxy-2-pyridinyl]carbonyl]-L-alaninate
Other status information
-
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Class (HRAC MoA class)
Not applicable
Herbicide Resistance Class (WSSA MoA class)
Not applicable
Insecticide Resistance Class (IRAC MoA class)
Not applicable
Fungicide Resistance Class (FRAC MOA class)
21
Examples of recorded resistance
None identified
Physical state
Fine, off-white coloured powder
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • Dow AgroSciences LLC
  • Corteva Agriscience
Example products using this active
  • Adavelt
  • Zetigo
Formulation and application details
Usually supplied as an emulsifiable concentrate formulation
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
4.0
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)
250000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Methanol
-
250000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Acetone
-
190
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
n-Heptane
-
250000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Ethyl acetate
-
Melting point (°C)
91
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
-
Boiling point (°C)
Decomposes before boiling
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
-
Degradation point (°C)
150
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
-
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
1.58 X 1004 Calculated -
Log P
4.2
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
High
Fat solubility of residues
Solubility
- - -
Data type
- - -
Density (g ml⁻¹)
1.28
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
-
Dissociation constant pKa) at 25 °C
- - -
-
Vapour pressure at 20 °C (mPa)
5.0 X 10-03
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
6.0 X 10-06
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Non-volatile
Volatilisation as max % of applied dose lost
From plant surface
- - -
From soil surface
- - -
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
Max at 265nm & 271nm
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
-
Surface tension (mN m⁻¹)
- - -
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
- - -
DT₅₀ (lab at 20 °C)
185
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Persistent
DT₅₀ (field)
2.5
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Non-persistent
DT₉₀ (lab at 20 °C)
- - -
DT₉₀ (field)
- - -
DT₅₀ modelling endpoint
- - -
Note
Australian Dossier 2022: Lab studies DT₅₀ (normalised) range 99-287 days, Field studies: DT₅₀ (measured) range 1.7-4.1 days
Dissipation rate RL₅₀ (days) on plant matrix
Value
- - -
Note
-
Dissipation rate RL₅₀ (days) on and in plant matrix
Value
- - -
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
0.12
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Fast
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
17
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Non-persistent
Note
pH sensitive: 13 days at pH4; 0.33 days at pH9
Water-sediment DT₅₀ (days)
- - -
Water phase only DT₅₀ (days)
31
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Stable
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
- - -
Koc
-
Notes and range
-
Freundlich
Kf
22
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Slightly mobile
Kfoc
1299
1/n
0.89
Notes and range
Australian dossier 2022: Kf range 13-43 mL g⁻¹, Kfoc range 1453-26372 mL g⁻¹
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
0.35 Calculated Low leachability
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
9.70 X 10-04 Calculated -
Note
-
Potential for particle bound transport index
Medium Calculated -
Potential for loss via drain flow
Slightly mobile Calculated -
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
- - -
Bio-concentration factor
BCF (l kg⁻¹)
- - -
CT₅₀ (days)
- -
Known soil metabolites
Metabolite
Major/Minor fraction
Estimated maximum occurrence fraction
Notes
Ref: X1285649
Major fraction 0.930 -
Ref: X12485631
Major fraction 0.330 -
Ref: X12485473
Major fraction 0.120 -
Known groundwater metabolites

None

Other known metabolites

None

ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
rat
Low
Mammals - Short term dietary NOEL
(mg kg⁻¹)
- - -
(ppm diet)
- -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
- - -
Birds - Acute LD₅₀ (mg kg⁻¹)
> 2000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Anas platyrhynchos
Low
Birds - Short term dietary (LC₅₀/LD₅₀)
- - -
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
- - -
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
> 3.3
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Eisenia andrei corr
High
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
- - -
Soil micro-organisms
- - -
Collembola
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
- - -
Non-target plants
> 134
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Solanum lycopersicum
Vegetative vigour ER25
as g ha⁻¹
-
> 300
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
ten species tested
Seedling emergence ER25
as g ha⁻¹
-
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 100
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Apis mellifera
Low
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 108
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Apis mellifera
Low
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Chronic NOEDD µg bee⁻¹
13
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Apis mellifera Adults
-
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other bee species (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other bee species (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Beneficial insects (Ladybirds) Mortality LR₅₀ g ha⁻¹
161
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Coccinella septempunctata
-
Beneficial insects (Lacewings) Mortality LR₅₀ g ha⁻¹
467
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Chrysoperla carnea
-
Beneficial insects (Parasitic wasps) Mortality LR₅₀ g ha⁻¹
297
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Aphidius rhopalosiphi
-
Beneficial insects (Predatory mites) Mortality LR₅₀ g ha⁻¹
55.0
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Typhlodromus pyri
-
Beneficial insects (Ground beetles)
- - -
Aquatic ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
> 0.011
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Oncorhynchus mykiss
High
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)
- - -
Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
0.059
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Daphnia magna
High
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
- - -
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
0.010
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Americamysis bahia
High
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
0.18
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Chironomus riparius as EC₅₀
Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
2.8
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Lemna gibba
Moderate
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
4.5
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Pseudokirchneriella subcapitata
Moderate
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
rat
Low
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
- - -
Mammals - Inhalation LC₅₀ (mg l⁻¹)
- - -
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.1
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Rabbit SF=100 Australia
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
None allocated
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Australia
-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
- - -
Dermal penetration studies (%)
- - -
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
-
Occupational
-
MRLs
European
EU MRL pesticide database 
Great Britain
GB MRL Register 
Notes
-
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Mammalian dose elimination route and rate
Metabolised and rapidly eliminated in faeces and urine
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database)
0 = No data
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source)
3 = Negative
XNo, known not to cause a problem
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
No data found
XNo, known not to cause a problem
XNo, known not to cause a problem
Eye irritant Phototoxicant  
?Possibly, status not identified
No data found  
General human health issues
May distrupt developmentcausibng reduced weights & decreased feeding
Handling issues
Property
Value and interpretation
General
Not hghly flammable
Not explosive or oxidising
CLP classification 2013
-
WHO Classification
Not listed (Not listed)
UN Number
-
Waste disposal & packaging
-
Shelf-life, storage, stability and reactivity
Stable for around 2 years under normal storage conditions
TRANSLATIONS
Language
Name
English
florylpicoxamid
French
florylpicoxamide
German
-
Danish
-
Italian
-
Spanish
-
Greek
-
Polish
-
Swedish
-
Hungarian
-
Dutch
-
Norwegian
-

Record last updated: 26/04/2024
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242