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florasulam (Ref: DE 570)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Florasulam is a post-emergent herbicide approved for use in the EU. It is highly soluble in water, volatile and there is a possibility, under certain conditions of it leaching to groundwater. It is not persistent in soil but may be persistent in aquatic systems. It has a low mammalian toxicity and is not thought to bioaccumulate. Whilst a recognised irritant no other serious human health issues have been reported. It is moderate to highly toxic to birds, most aquatic organims and honeybees. It has a low toxicity to earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for florasulam

Description: A herbicide used for post-emergence control of broad-leaved weeds

Example pests controlled: Broad-leaved weeds

Example applications: Wheat; Barley; Oats; Rye; Triticale

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1998, discovered; 1999 first reported & introduced

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Poland/Belgium
Date inclusion expires 31/12/2030
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C12H8F3N5O3S
Canonical SMILES COC1=NC=C(C2=NC(=NN21)S(=O)(=O)NC3=C(C=CC=C3F)F)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) QZXATCCPQKOEIH-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H8F3N5O3S/c1-23-12-16-5-8(15)10-17-11(18-20(10)12)24(21,22)19-9-6(13)3-2-4-7(9)14/h2-5,19H,1H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Triazolopyrimidine
Minimum active substance purity 970 g/kg
Known relevant impurities EU dossier - 2,6-DFA: <2.0 g/kg
Substance origin Synthetic
Mode of action Selective, absorbed by roots and shoots. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS.
CAS RN 145701-23-1
EC number -
CIPAC number 616
US EPA chemical code 129108
PubChem CID 11700495
Molecular mass (g mol-1) 359.28
PIN (Preferred Identification Name) N-(2,6-difluorophenyl)-8-fluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide
IUPAC name 2',6',8-trifluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonanilide
CAS name N-(2,6-difluorophenyl)-8-fluoro-5-methoxy(1,2,4)triazolo(1,5-c)pyrimidine-2-sulfonamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) B
Herbicide Resistance Classification (WSSA) 2
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Amaranthus retroflexus
Physical state Off-white coloured solid at 25 DegC, 99.7% purity
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Dow AgroSciences
Example products using this active
  • Barton WG
  • Boxer
  • Cabadex
  • Galaxy
  • Junction
  • Starane Gold
  • Starane Vantage
  • Starane XL
  • Zypar
UK LERAP status None
Formulation and application details Often supplied as wettable granules or soluble concentrate which are mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for florasulam

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 6360 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 0.019 A5 - n-Heptane -
227 A5 - Xylene -
9810 A5 - Methanol -
123000 A5 - Acetone -
Melting point (oC) 193.5 A4 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 202.5 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 6.03 X 10-02 Calculated -
Log P -1.22 A5 Low
Bulk density (g ml-1)/Specific gravity 1.53 A5 -
Dissociation constant (pKa) at 25oC 4.54 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 0.01 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 4.35 X 10-07 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.72 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.87 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Acidic solution: 259.8nm = 12200; [Basic solution: 262.4nm = 23600; [Methanolic solution @ pH 12.60: 204.1nm = 27400 A5 -
Surface tension (mN m-1) 71.5 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 1.85 A5 Non-persistent
DT50 (lab at 20oC) 1.85 A5 Non-persistent
DT50 (field) 8.5 A5 Non-persistent
DT90 (lab at 20oC) 6.57 A5 -
DT90 (field) 40.5 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 0.58-4.29 days, DT90 range 1.92-14.24 days, field studies DT50 range 2-18 days, DT90 range 23-61 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 1.4 R4 -
Note Published literature RL50 range 0.1-3.6 days, 4 field & undercover grown crops, various matrices, n=6
Aqueous photolysis DT50 (days) at pH 7 Value 156 A5 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 7 after 30 days, DT50 99 days at pH 9, all at 25 degC
Water-sediment DT50 (days) 13.3 A5 Fast
Water phase only DT50 (days) 18 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 0.46 A5 Mobile
Koc 22.0
Notes and range EU dossier Kd range 0.08-0.94 mL/g, Koc range 4-54 mL/g, Soils=6
Freundlich Kf 0.45 A5 Mobile
Kfoc 20.37
1/n 0.945
Notes and range EU dossier Kf range 0.03-1.88 mL/g, Kfoc range 2.0-54.7 mL/g, 1/n range 0.86-1.04, Soils=14
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
N-(2,6-difluorophenyl)-8-fluoro-5-hydroxy(1,2,4)triazolo(1,5-c)pyrimidine-2-sulfonamide This metabolite may cause environmental pollution, click here for further information Soil   0.716   Major fraction, Relevancy unknown
N-(2,6-difluorophenyl)-5-aminosulfonyl-1H-1,2,4-triazole-3-carboxylic acid This metabolite may cause environmental pollution, click here for further information Soil   0.178   Major fraction, Relevancy unknown
5-(aminosulfonyl)-1H-1,2,4-triazole-3-carboxylic acid This metabolite may cause environmental pollution, click here for further information Soil   0.400   Major fraction, Relevancy unknown


ECOTOXICOLOGY

for florasulam

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 1.5 A5 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 100 P4 Rat Moderate
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 1046 A5 Coturnix japonica Moderate
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A5 Coturnix japonica -
Fish - Acute 96 hour LC50 (mg l-1) > 100 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) > 119 A5 Oncorhynchus mykiss Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 292 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 38.9 A5 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 10.0 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.001 A5 Lemna spp. High
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.00894 A4 Unknown species High
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1320 A5 Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 25.2 Beneficial capacity
Dose: 0.0075 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 12.3 Beneficial capacity
Dose: 0.0075 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A4
Dose: 0.05 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for florasulam

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.0 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.05 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.05 A5 Dog, 90 day, SF=100 -
Dermal penetration studies (%) 12.0 A5 -
Dangerous Substances Directive 76/464 List II - -
Exposure Routes Public Minimal risk of dietary exposure; Very low risk to bystanders
Occupational Accetable risk for proposed uses with PPE/PPC
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C3; D0; E3

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Potential blood, adrenals, kidney and liver toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification U - Unlikely to present an acute hazard
UN Number Variable with formulation, usually 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for florasulam

Language Name
English florasulam
French florasulam
German Florasulam
Danish florasulam
Italian florasulame
Spanish florasulam
Greek florasulam
Slovenian florasulam
Polish florazulam
Swedish florasulam
Hungarian floraszuram
Dutch florasulam

Record last updated: Friday 28 June 2019
Contact: aeru@herts.ac.uk