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GET ADDITIONAL DATA HERE!

fluazinam (Ref: IKF 1216)
** B 1216 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for fluazinam

Description: A protective broad spectrum fungicide used to control various soil-borne fungal pathogens on a range of crops. It also has some acaricidal activity.

Example pests controlled: Sclerotinia blight, Late blight, White mould, Clubroot, Downy mildew, Scab, Alternaria blotch, Mites

Example applications: Peanuts; Potatoes; Grape vines; Fruit including citrus and apples; Crucifers

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1990, first marketed

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Austria/Denmark
Date inclusion expires 28/02/2020
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C13H4Cl2F6N4O4
Canonical SMILES C1=C(C=NC(=C1Cl)NC2=C(C=C(C(=C2[N+](=O)[O-])Cl)C(F)(F)F)[N+](=O)[O-])C(F)(F)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) UZCGKGPEKUCDTF-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C13H4Cl2F6N4O4/c14-6-1-4(12(16,17)18)3-22-11(6)23-9-7(24(26)27)2-5(13(19,20)21)8(15)10(9)25(28)29/h1-3H,(H,22,23)
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
Fluazinam - Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide, Acaricide
Substance group Phenylpyridinamine
Minimum active substance purity 960 g/kg
Known relevant impurities -
Substance origin Synthetic
Mode of action Protective action with some residual effects. Uncoupler of oxidative phosphorylation
CAS RN 79622-59-6
EC number -
CIPAC number 521
US EPA chemical code 129098
PubChem CID 91731
Molecular mass (g mol-1) 465.14
PIN (Preferred Identification Name) 3-chloro-N-[3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl]-5-(trifluoromethyl)pyridin-2-amine
IUPAC name 3-chloro-N-(3-chloro-5-trifluoromethyl-2-pyridyl)-α,α,α-trifluoro-2,6-dinitro-p-toluidine
CAS name 3-chloro-N-(3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-2-pyridinamine
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 29
Examples of recorded resistance -
Physical state Pale yellow crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Headland
  • Landgold
  • Makhteshim-Agan
  • Syngenta
Example products using this active
  • Shirlan
  • Tizca
  • Volley
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as a soluble concentrate which is mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for fluazinam

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.135 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 8000 A5 - n-Hexane -
192000 A5 - Methanol -
451000 A5 - Toluene -
853000 A5 - Acetone -
Melting point (oC) 117 A5 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.07 X 1004 Calculated -
Log P 4.03 A5 High
Bulk density (g ml-1)/Specific gravity 1.81 A5 -
Dissociation constant (pKa) at 25oC 7.34 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 7.5 A5 Moderately volatile
Henry's law constant at 25oC (Pa m3 mol-1) 25.9 A5 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.32 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.15 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) 66.3 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 11 B5 Non-persistent
DT50 (lab at 20oC) 72.5 A5 Moderately persistent
DT50 (field) 16.4 A5 Non-persistent
DT90 (lab at 20oC) 441 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 17-263 days, DT90 range 210-873 days, field studies DT50 range 67-254 days; Other studies: DT50 (1) Lab range 37-224 days, field range 6-15 days (B5), (2) 29 days (DW4)
Dissipation rate RL50 on plant matrix Value 4.3 R3 -
Note Grape berries, n=1
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 2.5 A5 Moderately fast
Note Degradation in daylight, stable in the dark
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 3.6 A5 Non-persistent
Note pH sensitive: stable at pH 4, DT50 3.7 days at pH 9
Water-sediment DT50 (days) 3.1 A5 Fast
Water phase only DT50 (days) 2.7 A4 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 220 A5 Non-mobile
Koc 16430
Notes and range EU dossier Kd range 126-264 mL/g, Koc range 10245-26250 mL/g, Soils=4
Freundlich Kf 26.6 A5 Slightly mobile
Kfoc 1958
1/n 0.65
Notes and range EU dossier Kf range 11.12-43.48 mL/g, Kfoc range 1705-2316 mL/g, 1/n range 0.6204-0.6813, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
5-((3-chloro-5-(trifluoromethyl)-2-pyridyl)amino)-alpha,alpha,alpha-trifluoro-4,6-dinitro-o-cresol This metabolite may cause environmental pollution, click here for further information Soil   0.139   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
3-chloro-N1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-6-nitro-4-(trifluoromethyl)-1,2-benzenediamine MAPA Animal; Water/sediment - -
5-chloro-6-[3-chloro-2, 6-dinitro-4-trifluoromethylanilino) nicotinic acid CAPA Water 0.940 -
6-(4-carboxy-3-chloro-2,6-dinitroanilino)-5-chloronicotinic acid DCPA Water - -
- G-504 Water - -
3-chloro-2-(2,6-diamino-3-chloro-alpha,alpha,alpha-trifluoro-p-toluidino)-5-(trifluoromethyl) pyridine DAPA Rat (Urinary, Faeces, Bile); Animal; Plant; Soil; Water/sediment - -
4-chloro-N2-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-3-nitro- 5-(trifluoromethyl)-1,2-benzenediamine AMPA Rat (Urinary, Faeces, Bile); Animal; Plant; Soil; Water/sediment - -
- AMPA mercapturate Rat (Urinary, Faeces, Bile) - -
- DAPA glucuronide Rat (Urinary, Faeces, Bile) - -
- DAPA cysteine conjugate Rat (Urinary, Faeces, Bile) - -
2-chloro-6-[(3-chloro-5-(trifluoromethyl)-2-pyridyl)-alpha,alpha,alpha-trifluoro-5-nitro-m-cresol
(Ref: SDS-67200/SDS-67230)
- Water/sediment; Water (Anaerobic) - -


ECOTOXICOLOGY

for fluazinam

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 1025 A5 Threshold for concern
CT50 (days) 5.5 -
Mammals - Acute oral LD50 (mg kg-1) > 4100 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 3.48 A4 Dog High
(ppm diet) > 1.0 -
Birds - Acute LD50 (mg kg-1) 1782 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) > 1230 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.055 A5 Lepomis macrochirus High
Fish - Chronic 21 day NOEC (mg l-1) 0.012 Q2 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.22 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0125 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.00625 A5 Chironomus riparius, emergence High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 53.6 P4 Lemna gibba Low
Non-target plants > 1500 A5 Cucumber
Vegetative vigour, ER50
as g/ha
-
> 1500 A5 Cucumber
Seedling emergence, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 0.16 A5 Pseudokirchneriella subcapitata, 96 hour Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.048 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 200 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) < 0.48 A5 Eisenia andrei Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect 1.57 A5 Folsomia candida, 28 day NOEC mg kg-1 -
Other arthropod (1) LR50 g ha-1 200 Mortality
A5 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2.27 mg kg-1, 28 days
-
Mesocosm study data NOEAEC mg l-1 0.01 A5 Zooplankton -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for fluazinam

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 4100 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.463 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 A5 Mouse, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.07 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.004 A5 Dog, SF=100 -
Dermal penetration studies (%) 1.5-7.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public Acceptable for proposed uses
Occupational Acceptable risk for operators for proposed uses with PPE/PPC
Acceptable risk for other farm workers for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Potential liver toxicant
May cause allergic contact dermatitis and occupational asthma
USEPA - some evidence to suggest possible human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
IMDG Transport Code is usually 9
CLP classification 2013 Health: H317, H318, H332, H361d
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Reproduction risk category 3: R63
T - Toxic: R23
Xn - Harmful: R41, R43
N - Dangerous for the environment: R53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for fluazinam

Language Name
English fluazinam
French fluazinam
German Fluazinam
Danish fluazinam
Italian fluazinam
Spanish fluazinam
Greek -
Slovenian fluazinam
Polish fluazynam
Swedish fluazinam
Hungarian fluazinam
Dutch -

Record last updated: Wednesday 03 April 2019
Contact: aeru@herts.ac.uk