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Bixlozone
Last updated: 18/08/2021
(Not known by any other names)

SUMMARY
Bixlozone is a herbicide used to control problematic grasses and broadleaved weeds in a wide range of crops. It is slightly soluble in water and is not highly volatile. Depending on local cobditions it can be moderately persistent in soils. It is hydrolytically stable. It is moderately toxic to birds. Bixlozone has a low oral mammalian toxicity.
Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
Moderate alert:
Moderately persistent; GUS: Transition state; Drainflow: Moderately mobile; Potential for particle bound transport: Medium
Ecotoxicity
Moderate alert:
Birds acute ecotoxicity: Moderate; Fish acute ecotoxicity: Moderate; Fish chronic ecotoxicity: Moderate; Earthworms acute ecotoxicity: Moderate
Human health
Low alert
GENERAL INFORMATION
Description
A herbicide used to control problematic grasses and broadleaved weeds
Example pests controlled
Ryegrass; Blackgrass; Broadleaved weeds
Example applications
Cereals; Maize; Legumes; Oilseed rape; Rice, Sugarcane
Efficacy & activity
-
Availability status
Current
Introduction & key dates
2021, Australia first launched
UK regulatory status
UK COPR regulatory status
Pending
Date COPR inclusion expires
-
UK LERAP status
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Pending
Dossier rapporteur/co-rapporteur
-
Date EC 1107/2009 inclusion expires
-
EU Candidate for substitution (CfS)
-
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
                 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
                 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
                 
Additional information
Also used in
Australia
Chemical structure
Isomerism
None
Chemical formula
C₁₂H₁₃Cl₂NO₂
Canonical SMILES
CC1(CON(C1=O)CC2=C(C=C(C=C2)Cl)Cl)C
Isomeric SMILES
-
International Chemical Identifier key (InChIKey)
FHUKASKVKWSLCY-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C12H13Cl2NO2/c1-12(2)7-17-15(11(12)16)6-8-3-4-9(13)5-10(8)14/h3-5H,6-7H2,1-2H3
2D structure diagram/image available?
Yes
General status
Pesticide type
Herbicide
Substance group
Isoxazolidinone
Minimum active substance purity
-
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Both systemic and contact activity. Blocks carotenoid biosynthesis in susceptible plants. Uptake is predominantly via roots and young shoots
CAS RN
81777-95-9
EC number
-
CIPAC number
-
US EPA chemical code
-
PubChem CID
-
Molecular mass
274.14
PIN (Preferred Identification Name)
2-[(2,4-dichlorophenyl)methyl]-4,4-dimethyl-1,2-oxazolidin-3-one
IUPAC name
2-(2,4-dichlorobenzyl)-4,4-dimethylisoxazolidin-3-one
CAS name
2-[(2,4-dichlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone
Other status information
-
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Classification (HRAC)
F4
Herbicide Resistance Classification (WSSA)
-
Insecticide Resistance Classification (IRAC)
Not applicable
Fungicide Resistance Classification (FRAC)
Not applicable
Examples of recorded resistance
-
Physical state
White crystalline solid
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • FMC Australasia
Example products using this active
  • Overwatch
  • Isoflex
Formulation and application details
Usually formulated as a suspension concentrate
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
39.6
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)
250000
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Acetone
-
120000
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Methanol
-
250000
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Ethy acetate
-
250000
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Toluene
-
Melting point (°C)
81.5
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
-
Boiling point (°C)
Decomposes before boiling
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
-
Degradation point (°C)
- - -
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
2.00 X 1003 Calculated -
Log P
3.3
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
High
Bulk density (g ml⁻¹)
1.37
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
-
Dissociation constant pKa) at 25 °C
- - -
-
Vapour pressure at 20 °C (mPa)
2.3 X 10-06
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
7.2 X 10-03
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Non-volatile
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
- - -
Surface tension (mN m⁻¹)
66.5
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
Not readily biodegradable
Soil degradation (days) (aerobic)
DT₅₀ (typical)
153
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Persistent
DT₅₀ (lab at 20 °C)
153
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Persistent
DT₅₀ (field)
93
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Not incorporated
Moderately persistent
DT₉₀ (lab at 20 °C)
- - -
DT₉₀ (field)
- - -
DT₅₀ modelling endpoint
- - -
Note
Australian 2019 dossier: Lab studies DT₅₀ range 64-330 days, Soils=7; Field studies (not incorporated) DT₅₀ range 46 to 267 days, Soils=7, Incorporated DT₅₀ = 31 to 446 days, Soils=7
Dissipation rate RL₅₀ on plant matrix
Value
- - -
Note
-
Dissipation rate RL₅₀ on and in plant matrix
Value
- - -
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
49
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Stable
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
Stable
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Stable
Note
Stable at all relevant pH's
Water-sediment DT₅₀ (days)
- - -
Water phase only DT₅₀ (days)
- - -
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
- - -
Koc
-
Notes and range
-
Freundlich
Kf
4.85
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Moderately mobile
Kfoc
400
1/n
0.84
Notes and range
Australian 2019 dossier Kf range 1.6-8.3 mL g⁻¹; Kfoc range 334-465 mL g⁻¹
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
2.75 Calculated Transition state
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
2.30 X 10-01 Calculated -
Note
-
Potential for particle bound transport index
Medium Calculated -
Potential for loss via drain flow
Moderately mobile Calculated -
Other known metabolites
Metabolite name and reference
Aliases
Formation medium / Rate
Estimated maximum occurrence fraction
Metabolising enzymes
F9600-3-OH-propanamide - Soil 0.150 -
2,4-dichlorobenzoic acid - Soil 0.006 -
ECOTOXICOLOGY
Property
Value
Source; quality score; and other information
Interpretation
Bio-concentration factor
BCF (l kg⁻¹)
- - -
CT₅₀ (days)
- -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Rat
Low
Mammals - Short term dietary NOEL
(mg kg⁻¹)
- - -
(ppm diet)
- -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
- - -
Birds - Acute LD₅₀ (mg kg⁻¹)
> 887
M4 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
4 = Verified data
Taeniopygia guttata
Moderate
Birds - Short term dietary (LC₅₀/LD₅₀)
- - -
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
- - -
Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
9.8
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Oncorhynchus mykiss
Moderate
Fish - Chronic 21 day NOEC (mg l⁻¹)
0.38
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Pimephales promelas
Moderate
Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
- - -
Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
- - -
Non-target plants
- - -
- - -
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
- - -
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 100
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Apis mellifera
Low
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 100
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Apis mellifera
Low
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other pollinators (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other pollinators (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
607
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Moderate
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
- - -
Other soil macro-organisms
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
- - -
Other arthropod (1)
LR₅₀ g ha⁻¹
- - -
% Effect
- - -
Other arthropod (2)
LR₅₀ g ha⁻¹
- - -
% Effect
- - -
Soil micro-organisms
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
- - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
Rat
Low
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
- - -
Mammals - Inhalation LC₅₀ (mg l⁻¹)
- - -
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.3
M5 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
5 = Verified data used for regulatory purposes
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
- - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
- - -
Dermal penetration studies (%)
- - -
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
Low risk for proposed uses
Occupational
Low risk for proposed uses
MRLs
European
EU MRL pesticide database 
Great Britain
GB MRL Register 
Notes
-
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database)
0 = No data
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E0 E = Unspecified genotoxicity type (miscellaneous data source)
0 = No data
No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
XNo, known not to cause a problem
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
No data found
?Possibly, status not identified
XNo, known not to cause a problem
Eye irritant Phototoxicant  
?Possibly, status not identified
XNo, known not to cause a problem
 
General human health issues
No information available
Handling issues
Property
Value and interpretation
General
Not highly flammable; Not expected to autoignite
Not oxidising or explosive
CLP classification 2013
-
EC Risk Classification
-
EC Safety Classification
-
WHO Classification
-
UN Number
-
Waste disposal & packaging
-
TRANSLATIONS
Language
Name
English
bixlozone
French
-
German
-
Danish
-
Italian
-
Spanish
-
Greek
-
Polish
-
Swedish
-
Hungarian
-
Dutch
-

Record last updated: 18/08/2021
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242