Dimpropyridaz	Last updated: 14/03/2024
(Also known as: trinconazole; Acetazolamide)

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SUMMARY

Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate	Ecotoxicity	Human health
Environmental fate Moderate alert: GUS: Transition state; Drainflow: Moderately mobile	Ecotoxicity Moderate alert: Birds acute ecotoxicity: Moderate; Birds chronic ecotoxicity: Moderate; Fish acute ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Bees acute contact ecotoxicity: Moderate; Bees acute oral ecotoxicity: Moderate; Bees acute unknown ecotoxicity: Moderate	Human health Moderate alert: Mammals acute toxicity: Moderate

GENERAL INFORMATION

Description	A pro-insecticide used to control sucking and chewing insect pests. Dimpropyridaz forms the secondary amide metabolite (pyridazine pyrazolecarboxamide), which is biologically active.
Example pests controlled	Aphids; Whiteflies;Thrips; Scale insects; Mealybugs; Psyllids; Leafhoppers
Example applications	Fruit; Vegetables including brassicas,; Grapes; Potatoes; Soybean; Beet; Oilseed rape; Ornamentals; Cotton
Efficacy & activity	Efficacy demonstrated by extensive field and glasshouse trials across across major growing regions of Australia & Tasmania
Availability status	Novel
Introduction & key dates	2019, launch; 2021, first product registered Australia

GB regulatory status

GB COPR regulatory status	Not approved
Date COPR inclusion expires	Not applicable
GB LERAP status	No UK approval for use as a pesticide

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status	Pending
Dossier rapporteur/co-rapporteur	Austria
Date EC 1107/2009 inclusion expires	Not applicable
EU Candidate for substitution (CfS)	No
Listed in EU database	Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States	ATAustria BEBelgium BGBulgaria CYCyprus CZCzech Republic DEGermany DKDenmark EEEstonia ELGreece                   ESSpain FIFinland FRFrance HRCroatia HUHungary IEIreland ITItaly LTLithuania LULuxembourg       ✓           LVLatvia MTMalta NLNetherlands PLPoland PTPortugal RORomania SESweden SISlovenia SKSlovakia
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries	ISIceland NONorway

Additional information

Also used in	Australia, Korea, Japan

Chemical structure

Isomerism	Substance is racemic. The S-entamiomer is the preferential form displaying greater biological activity
Chemical formula	C₁₆H₂₃N₅O
Canonical SMILES	-
Isomeric SMILES	-
International Chemical Identifier key (InChIKey)	NQPGZXOPMRKAGJ-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C16H23N5O/c1-6-20(14-7-8-17-18-9-14)16(22)15-10-19-21(13(15)5)12(4)11(2)3/h7-12H,6H2,1-5H3
2D structure diagram/image available?	Yes

General status

Pesticide type	Insecticide
Substance groups	Pyrazolecarboxamide insecticide; Carboximide insecticide
Minimum active substance purity	-
Known relevant impurities	-
Substance origin	Synthetic
Mode of action	Disrupts the function of insects sensory chordotonal organs
CAS RN	1403615-77-9
EC number	No data found
CIPAC number	None allocated
US EPA chemical code	-
PubChem CID	-
CLP index number	No data found
Molecular mass	301.39
PIN (Preferred Identification Name)	rac-N-ethyl-5-methyl-1-[(2R)-3-methylbutan-2-yl]-N-(pyridazin-4-yl)-1H-pyrazole-4-carboxamide
IUPAC name	1-[(1RS)-1,2-dimethylpropyl]-N-ethyl-5-methyl-N-pyridazin-4-yl-1H-pyrazole-4-carboxamide
CAS name	1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-4-pyridazinyl-1H-pyrazole-4-carboxamide
Other status information	-
Relevant Environmental Water Quality Standards	-
Herbicide Resistance Class (HRAC MoA class)	Not applicable
Herbicide Resistance Class (WSSA MoA class)	Not applicable
Insecticide Resistance Class (IRAC MoA class)	36
Fungicide Resistance Class (FRAC MOA class)	Not applicable
Examples of recorded resistance	-
Physical state	Tan to white coloured powdery solid

Formulations

Property	Value
Example manufacturers & suppliers of products using this active now or historically	BASF
Example products using this active	Axalion Efficon
Formulation and application details	Various formulations available including foliar sprays. denches and dips

ENVIRONMENTAL FATE

Property		Value	Source; quality score; and other information	Interpretation
Solubility - In water at 20 °C (mg l⁻¹)		28700	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	High
Solubility - In organic solvents at 20 °C (mg l⁻¹)		10000	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes n-Heptane	-
		67000	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Xylene	-
		250000	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Acetone	-
		250000	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Ethyl acetate	-
Melting point (°C)		81.9	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	-
Boiling point (°C)		-	-	-
Degradation point (°C)		208	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	-
Flashpoint (°C)		-	-	-
Octanol-water partition coefficient at pH 7, 20 °C	P	1.26 X 1001	Calculated	-
	Log P	1.1	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	Low
Fat solubility of residues	Solubility	-	-	-
	Data type	-	-	-
Density (g ml⁻¹)		-	-	-
Dissociation constant pKa) at 25 °C		No dissociation	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	-
		-
Vapour pressure at 20 °C (mPa)		8.7 X 10-03	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)		-	-	-
Volatilisation as max % of applied dose lost	From plant surface	-	-	-
	From soil surface	-	-	-
Maximum UV-vis absorption L mol⁻¹ cm⁻¹		-	-	-
Surface tension (mN m⁻¹)		52.9	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes at 20 °C 90% soln	-

Degradation

Property		Value	Source; quality score; and other information	Interpretation
General biodegradability		Not readily biodegradable
Soil degradation (days) (aerobic)	DT₅₀ (typical)	30	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	Moderately persistent
	DT₅₀ (lab at 20 °C)	30	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	Moderately persistent
	DT₅₀ (field)	22	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	Non-persistent
	DT₉₀ (lab at 20 °C)	-	-	-
	DT₉₀ (field)	-	-	-
	DT₅₀ modelling endpoint	-	-	-
	Note	Australian Dossier 2022: Lab studies DT₅₀ range 16-98 days, Soils=4; Field studies DT₅₀ range 9.1-81 days, Soils=12
Dissipation rate RL₅₀ (days) on plant matrix	Value	-	-	-
	Note	-
Dissipation rate RL₅₀ (days) on and in plant matrix	Value	-	-	-
	Note	-
Aqueous photolysis DT₅₀ (days) at pH 7	Value	47	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	Stable
	Note	-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7	Value	185	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	Persistent
	Note	-
Water-sediment DT₅₀ (days)		101.5	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	Slow
Water phase only DT₅₀ (days)		120	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	Stable
Sediment phase only DT₅₀ (days)		-	-	-
Air degradation		As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀		-

Soil adsorption and mobility

Property		Value	Source; quality score; and other information	Interpretation
Linear	Kd (mL g⁻¹)	-	-	-
	Koc (mL g⁻¹)	-
	Notes and range	-
Freundlich	Kf (mL g⁻¹)	2.58	P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data	Moderately mobile
	Kfoc (mL g⁻¹)	135.5
	1/n	-
	Notes and range	Australian dossier 2022. Kf range 0.1705.0 mL g⁻¹; Kfoc range 19-248 mL g⁻¹
pH sensitivity		-

Fate indices

Property		Value	Source; quality score; and other information	Interpretation
GUS leaching potential index		2.51	Calculated	Transition state
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate	Value	1.26 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		Low	Calculated	-
Potential for loss via drain flow		Moderately mobile	Calculated	-
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk		-	-	-
Bio-concentration factor	BCF (l kg⁻¹)	-	-	-
	CT₅₀ (days)	-		-

Known soil metabolites

Metabolite	Major/Minor fraction	Estimated maximum occurrence fraction	Notes
Ref: M550I001	Major fraction	0.510	-
Ref: M550I004	Major fraction	0.100	-
Ref: M550I005	-	-	-

Known groundwater metabolites

None

Other known metabolites

None

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property		Value	Source; quality score; and other information	Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)		465	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg⁻¹)	-	-	-
	(ppm diet)	-		-
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)		-	-	-
Birds - Acute LD₅₀ (mg kg⁻¹)		1778	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Colinus virginianus	Moderate
Birds - Short term dietary (LC₅₀/LD₅₀)		-	-	-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)		97	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Colinus virginianus	Moderate
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)		> 1000	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Eisenia foetida	Low
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)		> 285	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Eisenia foetida	Low
Soil micro-organisms		-	-	-
Collembola	Acute LC₅₀ (mg kg⁻¹)	-	-	-
	Chronic NOEC (mg kg⁻¹)	-	-	-
Non-target plants		> 300	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes 10 terrestrial plant ER₅₀ Tested at a single application rate of 300 g ai./ha	-
		-	-	-
Honeybees (Apis spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	> 50	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Lowest of 2 bee species	Moderate
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	> 42	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Lowest of 2 bee species	Moderate
	Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	> 45	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Bee larvae	Moderate
	Chronic	-	-	-
	Notes	-
Bumblebees (Bombus spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
		-
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
		-
Mason bees (Osmia spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
Other bee species (1)	Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)	-	-	-
	Mode of exposure	-
Other bee species (2)	Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)	-	-	-
	Mode of exposure	-
Beneficial insects (Ladybirds)		-	-	-
Beneficial insects (Lacewings)		-	-	-
Beneficial insects (Parasitic wasps) Mortality LR₅₀		34	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Aphidius rhopalosiphi	-
Beneficial insects (Predatory mites) Mortality LR₅₀		546	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Typhlodromus pyr	-
Beneficial insects (Ground beetles)		-	-	-

Aquatic ecotoxicology

Property		Value	Source; quality score; and other information	Interpretation
Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)		> 30	P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data Unknown species	Moderate
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)		11.0	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Pimephales promelas	Low
Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)		-	-	-
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)		> 30	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Daphnia magna	Moderate
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)		-	-	-
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)		-	-	-
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)		> 105	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Colinus virginianus	Low
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)		-	-	-
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)		-	-	-
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)		> 95.0	P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data Pseudokirchneriella subcapitata as ErC50	Low
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)		-	-	-
Mesocosm study data	NOEAEC mg l⁻¹	-	-	-
	NOEAEC mg l⁻¹	-	-	-
Marine bivalves		-	-	-

HUMAN HEALTH AND PROTECTION

General

Property		Value	Source; quality score; and other information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		High (class III)	-	-
Mammals - Acute oral LD₅₀ (mg kg⁻¹)		465	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Rat	Moderate
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)		2000	E4 E = Manufacturers safety data sheets 4 = Verified data Rat	-
Mammals - Inhalation LC₅₀ (mg l⁻¹)		-	-	-
Other Mammal toxicity endpoints		-	-	-
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)		0.2	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Australia	-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)		None allocated	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Australia	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Routes	Public	-
	Occupational	-
MRLs	European	EU MRL pesticide database
	Great Britain	GB MRL Register
	Notes	-
Drinking Water Standards		-	-	-
Drinking Water MAC (μg l⁻¹)		-	-	-
Mammalian dose elimination route and rate		-	-	-

Health issues

Specific human health issues		Carcinogen Genotoxic Endocrine disruptor XNo, known not to cause a problem A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative No data found Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant XNo, known not to cause a problem No data found XNo, known not to cause a problem Respiratory tract irritant Skin irritant Skin sensitiser No data found ?Possibly, status not identified XNo, known not to cause a problem Eye irritant Phototoxicant   ?Possibly, status not identified XNo, known not to cause a problem
General human health issues		No information available

Handling issues

Property	Value and interpretation
General	No explosive or oxidising Not expe cted to auto-ignite; Not highly flammable
CLP classification 2013	-
WHO Classification	Not listed (Not listed)
UN Number	-
Waste disposal & packaging	-
Shelf-life, storage, stability and reactivity	Stable for approx. 2 yrs at 20 degC

TRANSLATIONS

Language	Name
English	dimpropyridaz
French	dimpropyridaz
German	-
Danish	-
Italian	-
Spanish	-
Greek	-
Polish	-
Swedish	-
Hungarian	-
Dutch	-
Norwegian	-

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Record last updated:	14/03/2024
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242