The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Example manufacturers & suppliers of products using this active now or historically
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Example products using this active
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Formulation and application details
Usually supplied in liquid formulations
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
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-
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Solubility - In organic solvents at 20 °C (mg l⁻¹)
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-
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Melting point (°C)
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Boiling point (°C)
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-
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Degradation point (°C)
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-
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Flashpoint (°C)
-
-
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Octanol-water partition coefficient at pH 7, 20 °C
P
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Log P
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Fat solubility of residues
Solubility
-
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Data type
-
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Density (g ml⁻¹)
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Dissociation constant pKa) at 25 °C
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-
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Vapour pressure at 20 °C (mPa)
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Henry's law constant at 25 °C (Pa m³ mol⁻¹)
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Volatilisation as max % of applied dose lost
From plant surface
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From soil surface
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Maximum UV-vis absorption L mol⁻¹ cm⁻¹
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Surface tension (mN m⁻¹)
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Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
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Soil degradation (days) (aerobic)
DT₅₀ (typical)
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DT₅₀ (lab at 20 °C)
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DT₅₀ (field)
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DT₉₀ (lab at 20 °C)
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DT₉₀ (field)
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DT₅₀ modelling endpoint
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Note
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Dissipation rate RL₅₀ (days) on plant matrix
Value
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Note
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Dissipation rate RL₅₀ (days) on and in plant matrix
Value
-
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Note
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Aqueous photolysis DT₅₀ (days) at pH 7
Value
-
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Note
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Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
-
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Note
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Water-sediment DT₅₀ (days)
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Water phase only DT₅₀ (days)
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Sediment phase only DT₅₀ (days)
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Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀
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Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd (mL g⁻¹)
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Koc (mL g⁻¹)
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Notes and range
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Freundlich
Kf (mL g⁻¹)
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Kfoc (mL g⁻¹)
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1/n
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Notes and range
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pH sensitivity
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Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
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-
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SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
Cannot be calculated
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Note
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Potential for particle bound transport index
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Potential for loss via drain flow
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Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
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Bio-concentration factor
BCF (l kg⁻¹)
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CT₅₀ (days)
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Known soil metabolites
Metabolite
Major/Minor fraction
Estimated maximum occurrence fraction
Notes
maleic acid
Major fraction
-
-
Known groundwater metabolites
None
Other known metabolites
None
ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 10760
Q4 Q = Miscellaneous data from online sources 4 = Verified data
Rat
Low
Mammals - Short term dietary NOEL
(mg kg⁻¹)
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-
-
(ppm diet)
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Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
-
-
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Birds - Acute LD₅₀ (mg kg⁻¹)
> 2000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Anas platyrhynchos
Low
Birds - Short term dietary (LC₅₀/LD₅₀)
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Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
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Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
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Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
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Soil micro-organisms
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Collembola
Acute LC₅₀ (mg kg⁻¹)
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Chronic NOEC (mg kg⁻¹)
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Non-target plants
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Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
Q4 Q = Miscellaneous data from online sources 4 = Verified data
Rat
Low
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
2000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
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Mammals - Inhalation LC₅₀ (mg l⁻¹)
-
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Other Mammal toxicity endpoints
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ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.25
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
as maleic hydrazide
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ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
None allocated
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
as maleic hydrazide
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Dermal penetration studies (%)
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-
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Dangerous Substances Directive 76/464
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Exposure Routes
Public
No unacceptable risks to bystanders identified
Occupational
No unacceptable risks to operators or other workers identified
MRLs
European
EU MRL pesticide database
Great Britain
GB MRL Register
Notes
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Drinking Water Standards
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-
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Drinking Water MAC (μg l⁻¹)
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Mammalian dose elimination route and rate
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Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A3 A = Chromosome aberration (EFSA database) 3 = Negative
;
B0 B = DNA damage/repair (EFSA database) 0 = No data
;
C0 C = Gene mutation (EFSA database) 0 = No data
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
XNo, known not to cause a problem
XNo, known not to cause a problem
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
XNo, known not to cause a problem
Eye irritant
Phototoxicant
✓Yes, known to cause a problem
XNo, known not to cause a problem
General human health issues
Potential liver toxicant Possible mutagen; Suspected of causing genetic defects Ingestion might cause tremors and muscle spasms IARC Group 3 carcinogen - not classifiable
Handling issues
Property
Value and interpretation
General
IMDG Transport Hazard Class 9 Not explosive or oxidising Not expected to auto-ignite; Not highly flammable
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242
Ecotoxicity
Warning:
Human health
