The following Pesticide Hazard Tricolour (PHT) alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. The alerts for Highly Hazardous Pesticides (HHPs) are based on applying the FAO/WHO (Type 1) and the PAN (Type II) criteria to PPDB data. Further details on the HHP indicators are given in the tables below. Neither the PHT nor the HHP hazard alerts take account of usage patterns or exposure, thus they do not represent risk.
PHT: Environmental fate
PHT: Ecotoxicity
PHT: Human health
Highly Hazardous Pesticide
Environmental fate Moderate alert: Drainflow: Moderately mobile
Ecotoxicity High alert: Fish acute ecotoxicity: High
Human health Low alert
Highly Hazardous Pesticide (HHP) Type II alert
GENERAL INFORMATION
Description
A novel broad-spectrum, protective, third generation picolinamide fungicide
Example pests controlled
Alternaria diseases; Grey mold (Botrytis spp); Molds (Phytophthora spp.); Leaf spots (Pseudoperonospora spps.); Damping off and rots (Pythium) spp.
Example applications
Cereals; Soybean
Efficacy & activity
-
GB regulatory status
GB COPR regulatory status
Not approved
Date COPR inclusion expires
Not applicable
GB LERAP status
No UK approval for use as a plant protection agent
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Not approved
Dossier rapporteur/co-rapporteur
No applicable
Date EC 1107/2009 inclusion expires
Not applicable
EU Candidate for substitution (CfS)
Not applicable
Listed in EU database
No
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
 
 
 
 
 
 
 
 
 
Additional information
Also used in
-
Chemical structure
Isomerism
Metarylpicoxamid isomerism is primarily optical, due to the presence of multiple chiral centres in its molecular structure.
R09 Rule 9: Pesticide active ingredients that have demonstrated a high aquatic toxicity (where acute ecotoxicity for fish, invertebrates or algae =< 0.1 mg l⁻¹)
]
Other status information
-
Herbicide Resistance Class (HRAC MoA class)
Not applicable
Herbicide Resistance Class (WSSA MoA class)
Not applicable
Insecticide Resistance Class (IRAC MoA class)
Not applicable
Fungicide Resistance Class (FRAC MOA class)
21
Examples of recorded resistance
-
Physical state
White to light beige coloured, odourless solid
Commercial
Property
Value
Availability status
Novel
Introduction & key dates
2019, discovered; 2021, introduced; 2025, registration started Australia
Example manufacturers & suppliers of products using this active now or historically
Corteva Agriscience
Example products using this active
Vicroya Ora
Formulation and application details
Fomulated as an emulsifiable concentrate used asa foliar spray
Commercial production
Metarylpicoxamid is produced commercially through a scalable total chemical synthesis inspired by the natural product UK-2A. This non-macrocyclic structure, featuring fewer stereogenic centers than its predecessors like fenpicoxamid, facilitates efficient large-scale manufacturing by simplifying stereoselective steps, such as the tosylation of meso-2,3-butanediol to form a tosylate intermediate, followed by conversion to (2S,3S)-2,3-epoxybutane for amine moiety assembly, and subsequent coupling with a picolinic acid derivative.
Impact on climate of production and use
Metarylpicoxamid lacks published life cycle assessment data, however, based on available data for similar complex organic fungicides manufacturing emissions are estimated at 15–25 kg CO₂-e per kg of active compound. This range accounts for energy-intensive stereoselective synthesis steps (e.g., epoxide formation and coupling), raw material extraction and solvent use.
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C at pH 7 (mg l⁻¹)
3.6
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)
250000
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Acetone
-
250000
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Ethyl acetate
-
250000
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Xylene
-
195000
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Methanol
-
Melting point (°C)
89.5
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
-
Boiling point (°C)
256
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
-
Degradation point (°C)
-
-
-
Flashpoint (°C)
-
-
-
Octanol-water partition coefficient at pH 7, 20 °C
P
7.94 X 1003
Calculated
-
Log P
3.9
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
High
Fat solubility of residues
Solubility
-
-
-
Data type
-
-
-
Density (g ml⁻¹)
0.65
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
-
Dissociation constant pKa) at 25 °C
2.05
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
-
pKa(II) = 10.5
Vapour pressure at 20 °C (mPa)
4.0 X 10-04
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
-
Surface tension (mN m⁻¹)
59.0
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
at 20 °C 2.4 mg l⁻¹ water
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
0.35
P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data
Non-persistent
DT₅₀ (lab at 20 °C)
0.35
P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data
Non-persistent
DT₅₀ (field)
-
-
-
DT₉₀ (lab at 20 °C)
-
-
-
DT₉₀ (field)
-
-
-
DT₅₀ modelling endpoint
-
-
-
Note
Rapid degradation via photolysis DT₅₀ 8.4 hrs.
Dissipation rate RL₅₀ (days) on plant matrix
Value
-
-
-
Note
-
Dissipation rate RL₅₀ (days) on and in plant matrix
Value
-
-
-
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
-
-
-
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
42.0
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Moderately persistent
Note
DT₅₀ 0.93 days at pH9, 68.0 days at pH 4
Water-sediment DT₅₀ (days)
-
-
-
Water phase only DT₅₀ (days)
-
-
-
Sediment phase only DT₅₀ (days)
-
-
-
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀
-
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd (mL g⁻¹)
-
-
-
Koc (mL g⁻¹)
-
Notes and range
-
Freundlich
Kf (mL g⁻¹)
15.7
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Moderately mobile
Kfoc (mL g⁻¹)
290
1/n
0.9
Notes and range
Australia 2025 dossier: Kf range 4.2-23.0 L/kg, Kfoc range 84.0-499 L/kg, 1/n=0.9, Soils=7
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
-0.70
Calculated
Low leachability
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
7.08 X 10-05
Calculated
-
Note
-
Potential for particle bound transport index
Low
Calculated
-
Potential for loss via drain flow
Moderately mobile
Calculated
-
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
10.5
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Calculated using the Atkinson method. Assumed 1.5E+06 OH/cm³, 12 hr. EU trigger for long-range transport is DT₅₀ in air <2 days.
Below the level of concern for long-range air transport
Bio-concentration factor
BCF (l kg⁻¹)
97
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Low potential
CT₅₀ (days)
ND
-
Known soil metabolites
Metabolite
Major/Minor fraction
Estimated maximum occurrence fraction
Notes
Ref: X12644507
Major fraction
0.834
-
Ref: X12485473
Major fraction
0.145
-
Ref: X696476
Major fraction
0.314
-
Ref: X12797571
Minor fraction
-
-
Ref: X12781133
Minor fraction
-
-
Ref: X12673457
Minor fraction
-
-
Ref: X12648727
Minor fraction
-
-
Known groundwater metabolites
None
Other known metabolites
Metabolite name and reference
Aliases
Formation medium / Rate
Estimated maximum occurrence fraction
Ref: X12644507
-
Plants; Animal; Surface water; Sediment
-
Ref: X12648727
-
Plants; Surface water; Sediment
-
Ref: X12774135
-
Plants
-
Ref: X12777891
-
Plants
-
Ref: X12771309
-
Animal
-
Ref: X12851221
-
Animal
-
Ref: X12485473
-
Animal; Surface water
-
Ref: X12827475
-
Plants
-
Ref: X12797595
-
Plants
-
Ref: X12781133
-
Plants
-
Ref: X12801717
-
Plants
-
Ref: X12728263
-
Plants
-
Ref: X12734587
-
Plants
-
Ref: X12764267
-
Plants
-
Ref: X12728845
-
Plants
-
Ref: X12826475
-
Animal
-
Ref: XDE-747-MW-418
-
Animal
-
Ref: X12777919
-
Animal
-
Ref: X12771593
-
Animal
-
Ref: X12764795
-
Animal
-
Ref: X12745065
-
Animal
-
ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Rat
Low
Mammals - Short term dietary NOEL
(mg kg⁻¹)
-
-
-
(ppm diet)
-
-
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
-
-
-
Birds - Acute LD₅₀ (mg kg⁻¹)
> 609
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Anas platyrhynchos
Moderate
Birds - Short term dietary (LC₅₀/LD₅₀)
-
-
-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
> 1330
P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data
Colinus virginians as LDD₅₀
Low
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)
> 500
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242