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fluoxastrobin (Ref: HEC 5725)
** AE 1228646 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for fluoxastrobin

Description: A foliar applied, translaminar, systemic fungicide with preventative activity used for disease control on a wide range of vegetables

Example pests controlled: Early blight, Late blight, Leaf spots, Leaf rust, Rhizoctonia solani

Example applications: Vegetables; Turf; Peanuts; Potatoes; Onions; Cereals including wheat, rye, triticale, barley, oats

Efficacy & activity: Soybean/Blight=High; Soybean/Anthracnose=Moderate; Soybean/Brown spot=Moderate; Soybean/Leaf blight=Moderate. Data supported by field trials and extensive use.

Availability status: Current

Introduction & key dates: circa 2002

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK/Czech Republic
Date inclusion expires 31/07/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Isomeric - exists in both E- and Z- forms
Chemical formula C21H16ClFN4O5
Canonical SMILES CON=C(C1=CC=CC=C1OC2=C(C(=NC=N2)OC3=CC=CC=C3Cl)F)C4=NOCCO4
Isomeric SMILES CO/N=C(\C1=CC=CC=C1OC2=C(C(=NC=N2)OC3=CC=CC=C3Cl)F)/C4=NOCCO4
International Chemical Identifier key (InChIKey) UFEODZBUAFNAEU-NLRVBDNBSA-N
International Chemical Identifier (InChI) InChI=1S/C21H16ClFN4O5/c1-28-26-18(21-27-30-11-10-29-21)13-6-2-4-8-15(13)31-19-17(23)20(25-12-24-19)32-16-9-5-3-7-14(16)22/h2-9,12H,10-11H2,1H3/b26-18+
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
E-fluoxastrobin E-isomer Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Strobilurin
Minimum active substance purity 940 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic with protectant and curative properties. Respiration inhibitor (QoL fungicide).
CAS RN 361377-29-9
EC number -
CIPAC number 746
US EPA chemical code 028869
PubChem CID 11048796
Molecular mass (g mol-1) 458.83
PIN (Preferred Identification Name) -
IUPAC name (E)-{2-[6-(2-chlorophenoxy)-5-fluoropyrimidin-4-yloxy]phenyl}(5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyloxime
CAS name (1E)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimidinyl]oxy]phenyl](5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyloxime
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 11
Examples of recorded resistance -
Physical state White crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
  • Clayton
Example products using this active
  • Fandango
  • Jaunt
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as an emulsifiable concentrate that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for fluoxastrobin

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 2.56 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 40 A5 - n-Heptane -
38000 A5 - Xylene -
250000 A5 - Ethyl acetate -
1100 A5 - n-Octanol -
Melting point (oC) 103 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 230 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 7.24 X 1002 Calculated -
Log P 2.86 A5 Moderate
Bulk density (g ml-1)/Specific gravity 1.42 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 5.60 X 10-07 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.00 X 10-07 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.90 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.89 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 250nm = 19358, no absorbance above 290nm A5 -
Surface tension (mN m-1) 68.1 A5 at 20 oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Not readily biodegradable
Soil degradation (days) (aerobic) DT50 (typical) 58.8 A5 Moderately persistent
DT50 (lab at 20oC) 58.8 A5 Moderately persistent
DT50 (field) 52.6 A5 Moderately persistent
DT90 (lab at 20oC) 202.2 A5 -
DT90 (field) 335.4 A5 -
DT50 modelling endpoint 26.96 A5 geometric mean of normalised values -
Note EU 2018 dossier lab studies DT50 range 10.8-160.2 days, DT90 range 49.1-532.1 days, Soils=4; Field studies: DT50 range 11.5-91.7 days, DT90 range 93.6-552.8 days, Soils=5
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 33.4 A5 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 4 to pH 9
Water-sediment DT50 (days) 163 A5 Slow
Water phase only DT50 (days) 29 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 14.7 A5 Slightly mobile
Kfoc 848
1/n 0.86
Notes and range EU 2018 dossier Kf range 3.4-26.3 mL/g, Kfoc range 424-1582 mL/g, 1/n range 0.84-0.87, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
HEC-5725-des-chlorophenyl (Ref: HEC 7155) This metabolite may cause environmental pollution, click here for further information Soil   0.322   Major fraction, Relevant
HEC-5725-carboxylic acid (Ref: HEC 7180) This metabolite may cause environmental pollution, click here for further information Soil   0.169   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2-chlorophenol fluoxastrobin M82 Soil - -
- HEC 5725-phenoxy-hydroxypyrimidine; fluoxastrobin M55 Animal - -
- HEC 5725-2-chlorophenol-glucoside; fluoxastrobin M84 Plant - -
- HEC 5725-oxazepine; fluoxastrobin M36 Water (Photolysis) - -
- HEC5725-phenoxy-aminopyrimidine; fluoxastrobin M56 Water (Photolysis) - -
- HEC 5725-ketone; fluoxastrobin M34 Plant - -
- HEC 5725-carboxylic acid glycol ester; fluoxastrobin M39 Plant - -
- HEC 5725-hydroxy carboxylic acid; fluoxastrobin M41 Plant - -
- HEC 5725-OH-phenoxy-amino-PMD; fluoxastrobin M57 Plant - -
- HEC 5725-des-chlorophenyl-glycol-MA; fluoxastrobin M70 Plant - -
- HEC 5725-des-chlorophenyl-carboxylic acid; fluoxastrobin M72 Plant - -


ECOTOXICOLOGY

for fluoxastrobin

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 52.1 A5 Low potential
CT50 (days) 0.4 -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 1.5 A4 Dog High
(ppm diet) > 100 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 2000 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.435 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.0286 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.48 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.18 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.0604 A5 Americamysis bahia High
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 1.2 A3 Chironomus riparius, EC05 Development Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 6 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.35 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 200 A5 Apis mellifera Low
Oral acute 48 hour LD50 (μg bee-1) > 843 A5 Apis mellifera Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 1.33 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 34.1 Mortality
A5 Aphidius rhopalosiphi, adult
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 122.2 Mortality
A5 Typhlodromus pyri, protonymph
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2.83 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for fluoxastrobin

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.0 A5 Rat 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.015 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.08 A5 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) 0.08 A5 Dog, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.03 A5 Dog, 90 day, SF=100 -
Dermal penetration studies (%) 4.0 A5 -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public Minimal risk from dietary exposure
Risk assessment indicates ARfD would not normally be execeeded
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; Calc MAC=45 μg l-1; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Possible liver & kidney toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H332, H372
Environment: H400
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification NL - Not listed
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for fluoxastrobin

Language Name
English fluoxastrobin
French fluoxastrobine
German Fluoxastrobin
Danish fluoxastrobin
Italian fluoxastrobin
Spanish fluoxastrobeno
Greek -
Slovenian fluoksastrobin
Polish fluoksastrobina
Swedish -
Hungarian -
Dutch -

Record last updated: Friday 03 May 2019
Contact: aeru@herts.ac.uk