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GET ADDITIONAL DATA HERE!
fosthiazate (Ref: IKI 1145)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for fosthiazate

Description: A soil applied nematicide and insecticide used to control nematodes and sucking / chewing ground insects

Example pests controlled: Potato Cyst Nematode (Globodera rostochiensis, Globodera pallida), Wireworms

Example applications: Potatoes; Tomatoes; Vegetables

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1992, launched Japan; 2004, first registered USA

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Germany/Greece
Date inclusion expires 31/10/2020
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A molecule with 2 chiral centres giving four stereoisomers
Chemical formula C9H18NO3PS2
Canonical SMILES CCC(C)SP(=O)(N1CCSC1=O)OCC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) DUFVKSUJRWYZQP-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H18NO3PS2/c1-4-8(3)16-14(12,13-5-2)10-6-7-15-9(10)11/h8H,4-7H2,1-3H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Nematicide
Substance group Organophosphate
Minimum active substance purity 930 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic. Cholinesterase inhibitor.
CAS RN 98886-44-3
EC number -
CIPAC number 585
US EPA chemical code 129022
PubChem CID 91758
Molecular mass (g mol-1) 283.35
PIN (Preferred Identification Name) -
IUPAC name (RS)-[S-(RS)-sec-butyl O-ethyl 2-oxo-1,3-thiazolidin-3-ylphosphonothioate]
CAS name O-ethyl S-(1-methylpropyl) (2-oxo-3-thiazolidinyl)phosphonothioate
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance None recorded
Physical state Pale yellow liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Syngenta
Example products using this active
  • Nemathorin
  • Premier, Prime
UK LERAP status None
Formulation and application details Often supplied as fine granules applied directly to the soil.


ENVIRONMENTAL FATE

for fosthiazate

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 9000 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 15100 C4 - Hexane -
Miscible C4 - Acetone -
Miscible C4 - Methanol -
Miscible C4 - Ethyl acetate -
Melting point (oC) Not applicable A5 -
Boiling point (oC) 198 A5 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 4.79 X 1001 Calculated -
Log P 1.68 A5 Low
Bulk density (g ml-1)/Specific gravity 1.23 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.56 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.76 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.48 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 8.28 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Maxima circa 290 nm, 220nm = 5900 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 13 A5 Non-persistent
DT50 (lab at 20oC) 53 A5 Moderately persistent
DT50 (field) 13 A4 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) 45 A5 -
DT50 modelling endpoint - - -
Note Field studies DT50 range 9-17 days (USA), DT90 30-60 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 1.7 R3 -
Note Tomato fruit, n=1
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Not a significant degradation route
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 104 A5 Persistent
Note pH sensitive: DT50 177 days at pH 5, 3.2 days at pH 9, all at 25 degC
Water-sediment DT50 (days) 51 A5 Moderately fast
Water phase only DT50 (days) 36 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 1.97 R4 Moderately mobile
Koc 239
Notes and range Literature data: Kd range 1.48-2.77 mL/g; Koc range 162.0-286.7 mL/g, Soils=9
Freundlich Kf 1.22 A5 Mobile
Kfoc 59
1/n 0.89
Notes and range EU dossier Kfoc range 25-97 mL/g; Literature data: Kf range 0.10-2.75 mL/g; Kfoc range 16.9-286 mL/g, 1/n range 0.763-1.111, Soils=12 (R4)
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-butanesulfonic acid This metabolite may cause environmental pollution, click here for further information Soil   0.279   Major fraction, Not relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
RS)-s-sec-butyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate DETO Water (Hydrolysis) - -
(RS)-s-sec-butyl-o-ethylphosphorothioate DTTO Water (Hydrolysis) - -
- MBSo - - -
o-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonate DBTO Water (Hydrolysis) - -
1,3-thiazolidin-2-one TZO Water (Hydrolysis) - -
(Ref: SDS-67131)
Note: LC50(Worms) 14day: >1000 mg kg-1
BESoP Soil - -


ECOTOXICOLOGY

for fosthiazate

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 3.2 F4 Whole fish Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 57 A5 Rat High
Mammals - Short term dietary NOEL (mg kg-1) 0.5 A4 Dog High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 10 A5 Colinus virginianus High
Birds - Short term dietary (LC50/LD50) 139 ppm A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 114 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 7.8 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.282 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.06 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.1 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 4.51 A5 Anabaena flos-aquae Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.256 A5 Apis mellifera High
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.61 A5 Apis mellifera High
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 209 A5 Eisenia foetida Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) 100 A5 Eisenia foetida Moderate
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 3.4 Mortality
Dose: 4 kg ha-1
A4 Poecilus cupreus
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 53 mg kg-1 soil, 60 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for fosthiazate

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 57 A5 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 853 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.56 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.004 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.005 A5 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.005 A4 Dog, 90 day, SF=100 -
Dermal penetration studies (%) 10.0 A5 -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Routes Public Minimal risk of dietary exposure
Negligible risk to bystanders
Occupational No unacceptable risks for operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E0

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues No further information available
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H301, H312, H317, H331
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R23/25, R39
Xn - Harmful: R21, R41, R43
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S25, S26, S39, S45, S53, S60, S61
WHO Classification NL - Not listed
UN Number 3018
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for fosthiazate

Language Name
English fosthiazate
French fosthiazate
German Fosthiazat
Danish fosthiazat
Italian fostiazate
Spanish fostiazato
Greek -
Slovenian fostiazat
Polish fostiazat
Swedish -
Hungarian fosztiazat
Dutch fosthiazaat

Record last updated: Monday 11 November 2019
Contact: aeru@herts.ac.uk