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ancymidol (Ref: EL 531)
** ancymidole ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Ancymidol is a plant growth regulator that is not approved for use in the EU. It is volatile and highly soluble in water. It is not persistent in soil systems and generally not persistent in water. It is moderately mobile and so there is a risk of leaching to groundwater under some conditions. It has a moderate mammalian toxicity but is not expected to bioaccumulate. Ancymidol is moderately toxic to fish, aquatic invertebrates, aquatic plants and honey bees. However it is less toxic to algae and birds.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for ancymidol

Description: A plant growth inhibitor used to produce more compact horticultural, non-food plants

Example pests controlled: Growth - internodal elongation to improve plant shape

Example applications: Ornamentals particularly container grown herbaceous plants and woody shrubs

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1973, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur -
Date inclusion expires Expired
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule
Chemical formula C15H16N2O2
Canonical SMILES COC1=CC=C(C=C1)C(C2CC2)(C3=CN=CN=C3)O
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) HUTDUHSNJYTCAR-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C15H16N2O2/c1-19-14-6-4-12(5-7-14)15(18,11-2-3-11)13-8-16-10-17-9-13/h4-11,18H,2-3H2,1H3
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
Ancymidol Unstated isomer Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Plant growth regulator
Substance group Pyrimidinyl carbinol
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Absorbed by leaves and roots, acts via the inhibition of gibberellin biosynthesis: Gibberellin antagonist
CAS RN 12771-68-5
EC number 235-814-7
CIPAC number 8017
US EPA chemical code 108601
PubChem CID 25572
Molecular mass (g mol-1) 256.30
PIN (Preferred Identification Name) rac-(R)-cyclopropyl(4-methoxyphenyl)(pyrimidin-5-yl)methanol
IUPAC name (RS)-α-cyclopropyl-4-methoxy-α-(pyrimidin-5-yl)benzyl alcohol
CAS name α-cyclopropyl-α-(4-methoxyphenyl)-5-pyrimidinemethanol
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White crystalline solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Fine Chemicals
  • Sepro Corp
  • Elanco
Example products using this active
  • Quel
  • A-rest
  • Reducymol
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as a soluble concentrate.


ENVIRONMENTAL FATE

for ancymidol

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 650 H4 High
Solubility - In organic solvents at 20oC (mg l-1) 250000 L3 - Methanol -
250000 L3 - Acetone -
37000 L3 - Hexane -
Melting point (oC) 110.5 L3 -
Boiling point (oC) Decomposes before boiling F4 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable F4 -
Octanol-water partition coefficient at pH 7, 20oC P 8.13 X 1001 Calculated -
Log P 1.91 H4 Low
Bulk density (g ml-1)/Specific gravity 0.42 F4 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 0.13 H4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.58 X 10-06 H4 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 4.33 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.96 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 15 H4 Non-persistent
DT50 (lab at 20oC) 120 Q3 Persistent
DT50 (field) 15 H4 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Some studies quote DT50 as high as 120 days (US3)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 30 W4 Moderately persistent
Note Hydrolysis is not pH sensitive in range 5-9, 25 degC
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - H3 Moderately mobile
Koc 83
Notes and range Best available data
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for ancymidol

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 8.38 Q2 Estimated Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 1721 F4 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - L3 Rat -
(ppm diet) 8000 -
Birds - Acute LD50 (mg kg-1) 5192 F2 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 100 F4 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 100 F4 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.193 F3 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 26.9 F3 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 F4 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for ancymidol

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1721 F4 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 200 L3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 5.6 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Due to usage pattern the risk to bystanders and consumers is negligible
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Moderately toxic
May cause respiratory problems
Physical dependence may develop

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Incompatible with strong oxidizing agents and acids
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R20/21/22
EC Safety Classification Click here to view information omn the EU safety phrases S24/25, S36/37/39
WHO Classification III - Slightly hazardous
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for ancymidol

Language Name
English ancymidol
French ancymidole
German Ancymidol
Danish ancymidol
Italian ancimidol
Spanish ancimidol
Greek -
Slovenian ancimidol
Polish ancymidol
Swedish -
Hungarian -
Dutch -

Record last updated: Tuesday 30 October 2018
Contact: aeru@herts.ac.uk