Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!

icaridin (Ref: KBR 3023)
** icaradine ** picaradin ** propidine ** autan ** hydroethyl isobutyl piperidine carboxylate ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
Further data may be found in the VSDB

SUMMARY

Icaridin is an insect repellant without EU regulatory approval for use. It has a high aquatic solubility and is volatile. Data is limited regarding its environmental persistence. It has a relatively low mammalian toxicity and a high potential to bioaccumulate. It is is not highly toxic to birds or fish. There are gaps in ecotoxicology and environmental fate data.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for icaridin

Description: An insect repellant used for both human and animal applications to control a broad spectrum of insect pests

Example pests controlled: Biting flies, Mosquitoes, Ticks, fleas

Example applications: Humans; Livestock

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 2001, USA first registered

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database No

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A molecule with 2 chiral centres
Chemical formula C12H23NO3
Canonical SMILES CCC(C)OC(=O)N1CCCCC1CCO
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) QLHULAHOXSSASE-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H23NO3/c1-3-10(2)16-12(15)13-8-5-4-6-11(13)7-9-14/h10-11,14H,3-9H2,1-2H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Repellent, Veterinary substance
Substance group Piperidine
Minimum active substance purity 970 g/kg
Known relevant impurities None declared by manufacturer; Chemistry suggests sec-butyl chloroformate & sec-butyl carbonic anhydride
Substance origin Synthetic
Mode of action Topically applied, repellent
CAS RN 119515-38-7
EC number 423-210-8
CIPAC number 740
US EPA chemical code 070705
PubChem CID 125098
Molecular mass (g mol-1) 229.32
PIN (Preferred Identification Name) -
IUPAC name (RS)-sec-butyl (RS)-2-(2-hydroxyethyl)piperidine-1-carboxylate
CAS name 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not known
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Colourless, odourless liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer
  • Lanxess Corp
Example products using this active
  • Bayrepel
  • Saltidin
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Available in a variety of formulations including aerosol sprays, pump sprays and towelette wipes.


ENVIRONMENTAL FATE

for icaridin

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 8200 F4 High
Solubility - In organic solvents at 20oC (mg l-1) Miscible F4 - Propanol -
Miscible F4 - Ethanol -
Melting point (oC) -170 F3 - Freezing point -
Boiling point (oC) 296 F4 -
Degradation point (oC) - - -
Flashpoint (oC) 375 F4 -
Octanol-water partition coefficient at pH 7, 20oC P 1.70 X 1002 Calculated -
Log P 2.23 F4 Low
Bulk density (g ml-1)/Specific gravity 1.04 Q2 -
Dissociation constant (pKa) at 25oC Not applicable Q4 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.034 F4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) - - -
GUS leaching potential index Click here for a note on the limitations of the GUS index - - -
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value - - -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - - -
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) - - -
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note: -
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable F4 -
Note Stable under normal environmental conditions
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - CA2 Moderately mobile
Koc 389
Notes and range Estimated
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for icaridin

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 1.8 F4 (whole body) Low potential
CT50 (days) ND -
Mammals - Acute oral LD50 (mg kg-1) 2236 F3 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 100 Q4 Rat Moderate
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 5000 F4 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 173 F4 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 50.1 F4 Oncorhynchus mykiss Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 100 Q2 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 103 F3 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 71.5 F4 Scenedemus subspicatus Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) 54.8 F4 Scenedesmus subspicatus Low
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for icaridin

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 2236 F3 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 F4 Rat -
Mammals - Inhalation LC50 (mg l-1) > 4.36 F4 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public -
Occupational Occupational exposure may occur through inhalation and dermal contact
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A0; B0; C0; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues No further information available
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Not classified: Obsolete
EC Risk Classification Click here to view information omn the EU risk phrases Not classified: Obsolete
EC Safety Classification Click here to view information omn the EU safety phrases Not classified: Obsolete
WHO Classification III/O - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for icaridin

Language Name
English icaridin
French icaridin
German Icaridin
Danish icaridin
Italian icaridin
Spanish icaridin
Greek -
Slovenian ikaridin
Polish ikarydyna
Swedish icaridin
Hungarian -
Dutch -

Record last updated: Tuesday 02 July 2019
Contact: aeru@herts.ac.uk