Top Environmental Fate Ecotoxicology Human Health Translations
Home
A to Z: All
A to Z: Insecticides
A to Z: Herbicides
A to Z: Fungicides
A to Z: Other product constituents
Search
Support information
Purchasing and licensing
Isofenphos (Ref: BAY SRA 12869)
Last updated: 23/05/2018
(Also known as: isophenphos; BAY 92114)

GENERAL INFORMATION
Description
An obsolete insecticide once used to control soil-dwelling insects
Example pests controlled
White grubs; Cabbage root flies; Corn roundworms; Wireworms; Mole crickets
Example applications
Turf; Ornamental trees and shrubs; Corn; Maize; Carrots
Efficacy & activity
-
Availability status
Obsolete
Introduction & key dates
1974, first reported
UK regulatory status
UK approval status
Not approved
EC Regulation 1107/2009 (repealing 91/414)
EC Directive 91/414 Status
Not approved
Dossier rapporteur/co-rapporteur
-
Date inclusion expires
Expired
EU Candidate for substitution (CfS)
-
Listed in EU database
Yes
Approved for use (✓) or known to be used (#) in the following EU-27 Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
                 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
                 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
                 
Also used in
Also used in
Australia
Chemical structure
Isomerism
A chiral molecule
Chemical formula
C₁₅H₂₄NO₄PS
Canonical SMILES
CCOP(=S)(NC(C)C)OC1=CC=CC=C1C(=O)OC(C)C
Isomeric SMILES
No data
International Chemical Identifier key (InChIKey)
HOQADATXFBOEGG-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C15H24NO4PS/c1-6-18-21(22,16-11(2)3)20-14-10-8-7-9-13(14)15(17)19-12(4)5/h7-12H,6H2,1-5H3,(H,16,22)
2D structure diagram/image available?
Yes
General status
Pesticide type
Insecticide
Substance group
Organophosphate
Minimum active substance purity
-
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Selective with contact and stomach action. Acetylcholine esterase inhibitor.
CAS RN
25311-71-1
EC number
246-814-1
CIPAC number
412
US EPA chemical code
109401
PubChem CID
32872
Molecular mass
345.39
PIN (Preferred Identification Name)
-
IUPAC name
O-ethyl O-2-isopropoxycarbonylphenylisopropylphosphoramidothioate
CAS name
1-methylethyl 2-((ethoxy((1-methylethyl)amino)phosphinothioyl)oxy)benzoate
Other status information
PAN Bad actor chemical; Marine Pollutant
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Classification (HRAC)
Not applicable
Herbicide Resistance Classification (WSSA)
Not applicable
Insecticide Resistance Classification (IRAC)
1B
Fungicide Resistance Classification (FRAC)
Not applicable
Examples of recorded resistance
Myzus persicae
Physical state
Colourless oily liquid with characteristic odour
Related substances & organisms
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • Amaze
  • Oftanol
  • Pryfon
Example products using this active
  • Bayer CropScience
  • Mobay
UK LERAP status
No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details
Available in a variety of formulations including emulsifiable concentrate, dry seed treatments, granules and wettable powder formulations
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
24
G4 G = Extension Toxicology network database EXTOXNET (click here )
4 = Verified data
Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)
200000
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
Isopropanol
-
200000
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
Toluene
-
200000
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
Dichloromethane
-
Melting point (°C)
-12
Q3 Q = Miscellaneous internet resources
3 = Unverified data of known source
-
Boiling point (°C)
120
Q3 Q = Miscellaneous internet resources
3 = Unverified data of known source
-
Degradation point (°C)
- - -
Flashpoint (°C)
115
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
-
Octanol-water partition coefficient at pH 7, 20 °C
P
1.10 X 1004 Calculated -
Log P
4.04
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
High
Bulk density (g ml⁻¹)
1.13
AC4 AC = EC Joint Research Centre ESIS European Chemical Substance Information Systems including EINECS, now integrated with the database provided by the European Chemicals Agency (ECHA) (click here )
4 = Verified data
-
Dissociation constant pKa) at 25 °C
- - -
-
Vapour pressure at 20 °C
0.53
G4 G = Extension Toxicology network database EXTOXNET (click here )
4 = Verified data
Low volatility
Henry's law constant at 25 °C
4.20 X 10-03
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
Non-volatile
GUS leaching potential index
2.66 Calculated Transition state
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
2.07 X 10-01 Calculated -
Note
-
Potential for particle bound transport index
Medium Calculated -
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
- - -
Surface tension (mN m⁻¹)
- - -
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
150
M4 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems) (click here )
4 = Verified data
Persistent
DT₅₀ (lab at 20 °C)
- - -
DT₅₀ (field)
- - -
DT₉₀ (lab at 20 °C)
- - -
DT₉₀ (field)
- - -
DT₅₀ modelling endpoint
- - -
Note
Best available data
Dissipation rate RL₅₀ on plant matrix
Value
18.2
R3 R = Peer reviewed scientific publications
3 = Unverified data of known source
-
Note
Kentucky bluegrass, blades, n=1
Dissipation rate RL₅₀ on and in plant matrix
Value
3.7
R3 R = Peer reviewed scientific publications
3 = Unverified data of known source
-
Note
Turfgrass, n=1
Aqueous photolysis DT₅₀ (days) at pH 7
Value
- - -
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
365
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
Very persistent
Note
-
Water-sediment DT₅₀ (days)
- - -
Water phase only DT₅₀ (days)
- - -
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
-
G3 G = Extension Toxicology network database EXTOXNET (click here )
3 = Unverified data of known source
Slightly mobile
Koc
600
Notes and range
Best available data
Freundlich
Kf
- - -
Kfoc
-
1/n
-
Notes and range
-
pH sensitivity
-
ECOTOXICOLOGY
Property
Value
Source; quality score; and other information
Interpretation
Bio-concentration factor
BCF (l kg⁻¹)
240
P4 P = Other governments and regulators
4 = Verified data
Threshold for concern
CT₅₀ (days)
Not available -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 28
G4 G = Extension Toxicology network database EXTOXNET (click here )
4 = Verified data
Rat
High
Mammals - Short term dietary NOEL
(mg kg⁻¹)
-
L2 L = Pesticide manuals and hard copy reference books / other sources
2 = Unverified data of unknown source
Rat 2 year
-
(ppm diet)
1 -
Birds - Acute LD₅₀ (mg kg⁻¹)
> 13
G4 G = Extension Toxicology network database EXTOXNET (click here )
4 = Verified data
Colinus virginianus
High
Birds - Short term dietary (LC₅₀/LD₅₀)
299 mg kg bw⁻¹ day⁻¹
G4 G = Extension Toxicology network database EXTOXNET (click here )
4 = Verified data
Colinus virginianus
-
Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
1.8
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment )
3 = Unverified data of known source
Lepomis macrochirus
Moderate
Fish - Chronic 21 day NOEC (mg l⁻¹)
0.066
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment )
3 = Unverified data of known source
Oncorhynchus mykiss 28 day LOEC
Moderate
Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
0.0039
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
Daphnia magna
High
Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
0.0004
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment )
3 = Unverified data of known source
Americamysis bahia
High
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
- - -
Non-target plants
- - -
- - -
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
6.8
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
Scenedemus subspicatus
Moderate
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 0.61
K4 K = Research datasets, e.g. Pandora, Demetra
4 = Verified data
High
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
Toxic
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
Toxic
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other pollinators (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other pollinators (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
> 404
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
Eisenia foetida
Moderate
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
- - -
Other soil macro-organisms
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
- - -
Other arthropod (1)
LR₅₀ g ha⁻¹
- - -
% Effect
- - -
Other arthropod (2)
LR₅₀ g ha⁻¹
- - -
% Effect
- - -
Soil micro-organisms
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 28
G4 G = Extension Toxicology network database EXTOXNET (click here )
4 = Verified data
Rat
High
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
162
G4 G = Extension Toxicology network database EXTOXNET (click here )
4 = Verified data
Rabbit
-
Mammals - Inhalation LC₅₀ (mg l⁻¹)
0.2
AC4 AC = EC Joint Research Centre ESIS European Chemical Substance Information Systems including EINECS, now integrated with the database provided by the European Chemicals Agency (ECHA) (click here )
4 = Verified data
Rat 4 hr
-
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.001
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment )
3 = Unverified data of known source
JMPR 1986
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
- - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
- - -
Dermal penetration studies (%)
- - -
Dangerous Substances Directive 76/464
List I; List II - -
Exposure Routes
Public
-
Occupational
May be absorbed through the skin
European MRLs
EU MRL pesticide database 
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A3 A = Chromosome aberration (EFSA database)
3 = Negative
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source)
3 = Negative
No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
?Possibly, status not identified
Yes, known to cause a problem
Yes, known to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
XNo, known not to cause a problem
Yes, known to cause a problem
No data found
Eye irritant Phototoxicant  
Yes, known to cause a problem
No data found  
General human health issues
Toxic in contact with skin or if swallowed
Central, peripheral nervous systems and blood toxicant
Handling issues
Property
Value and interpretation
General
No information available
CLP classification 2013
Health: H301, H311
Environment: H400, H410
EC Risk Classification
T - Toxic: R24/25
N - Dangerous for the environment: R50, R53
EC Safety Classification
S1/2, S36/37, S45, S60, S61
WHO Classification
Ib (Highly hazardous / Highly hazardous)
UN Number
-
Waste disposal & packaging
-
TRANSLATIONS
Language
Name
English
isofenphos
French
isophenphos
German
Isofenphos
Danish
isofenphos
Italian
isofenfos
Spanish
isofenfos
Greek
isofenphos
Polish
izofenfos
Swedish
-
Hungarian
-
Dutch
isofenfos

Record last updated: 23/05/2018
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242