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GET ADDITIONAL DATA HERE!

isoxaflutole (Ref: RPA 201772)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for isoxaflutole

Description: A broad-spectrum pre-emergence soil herbicide for the control of weeds in maize and sugarcane

Example pests controlled: Broad-leaved-weeds; Annual grasses

Example applications: Maize; Sugar cane

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1998, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Italy/Slovenia
Date inclusion expires 31/07/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia; USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C15H12F3NO4S
Canonical SMILES CS(=O)(=O)C1=C(C=CC(=C1)C(F)(F)F)C(=O)C2=C(ON=C2)C3CC3
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) OYIKARCXOQLFHF-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C15H12F3NO4S/c1-24(21,22)12-6-9(15(16,17)18)4-5-10(12)13(20)11-7-19-23-14(11)8-2-3-8/h4-8H,2-3H2,1H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Oxyacetamide
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic absorbed by roots and leaves. Bleaching: inhibition of 4-hydroxyphenyl-pyruvate-dioxygenase.
CAS RN 141112-29-0
EC number -
CIPAC number 575
US EPA chemical code 123000
PubChem CID 84098
Molecular mass (g mol-1) 359.32
PIN (Preferred Identification Name) -
IUPAC name (5-cyclopropyl-1,2-oxazol-4-yl)(α,α,α-trifluoro-2-mesyl-p-tolyl)methanone
CAS name (5-cyclopropyl-4-isoxazolyl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]methanone
Other status information Phytotoxic
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) F2
Herbicide Resistance Classification (WSSA) 27
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Off-white solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
  • Rhone-Poulenc Ag Company
Example products using this active
  • Cadu Star
  • Balance Herbicide
  • Balance Pro
  • Merlin
  • Flexx
  • Spade
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Usually supplied as water dispersible granules.


ENVIRONMENTAL FATE

for isoxaflutole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 6.2 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 293000 A5 - Acetone -
142000 A5 - Ethyl acetate -
31200 A5 - Toluene -
13800 A5 - Methanol -
Melting point (oC) 140 A4 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 205 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.19 X 1002 Calculated -
Log P 2.34 A5 Low
Bulk density (g ml-1)/Specific gravity 1.59 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 3.22 X 10-05 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.87 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.10 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.50 X 10-04 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 204nm = 22668, 269.4nm = 11764, No absorption <290nm
Acid solution: 205.4nm = 22393, 269.2nm= 11788
Basic solution: 218.4nm = 18262, 292nm = 12861
A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 0.9 Click here to see a warning relating to modelling and this active substance A5 Non-persistent
DT50 (lab at 20oC) 0.9 A5 Non-persistent
DT50 (field) 1.3 A5 Non-persistent
DT90 (lab at 20oC) 30.1 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier (2016) lab studies DT50 range 0.2-5.9 days, DT90 range 0.94-35.8 days, Soil =5; Field study DT50 range 0.5-2.4 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 1.7 A5 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 0.8 A5 Non-persistent
Note pH sensitive: DT50 11 days pH 4 and pH 5, 3.2 hours at pH 9, all at 25 degC
Water-sediment DT50 (days) 0.36 A5 Fast
Water phase only DT50 (days) 0.36 A5 Fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 2.8 R4 Moderately mobile
Koc 145
Notes and range Literature data Kd range 1.24-3.77 mL/g, Koc range 124-160 mL/g, soils=4
Freundlich Kf 2.73 A5 Moderately mobile
Kfoc 79.8
1/n 0.94
Notes and range EU dossier (2016)Kd range 0.24-8.15 mL/g, Kfoc range 48-109 mL/g, 1/n range 0.87-1.03, Soils=4; Other litertaure data Kf range 1.17-3.22 mL/g, Kfoc range 117-136 mL/g, Soils=4 (R4)
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
(2RS)-3-cyclopropyl-2-(2-(methylsulfonyl)-4-(trifluoromethyl)benzoyl)-3-oxopropanenitrile (Ref: RPA 202248) This metabolite may cause environmental pollution, click here for further information Soil   0.964   Major fraction, Relevancy unknown
2-mesyl-4-trifloromethylbenzoic acid (Ref: RPA 203328) This metabolite may cause environmental pollution, click here for further information Soil   0.900   Major fraction, Relevancy unknown

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: RPA 205834)
Note: LC50(fish) = 35 mg l-1; LC50(Daphnia) = 100 mg l-1
- Water; Sediment - -


ECOTOXICOLOGY

for isoxaflutole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 11 A5 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 2 L2 Rat, 2 year High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2150 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 4150 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) > 1.7 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.08 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 1.5 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.35 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.014 F3 Americamysis bahia High
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.1 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.016 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.12 A4 Raphidocelis subcapitata, 120 hour Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 168.7 A5 Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 61 Parasitism
Dose: 0.15 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 15 Mortality and Fecundity
Dose: 0.15 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 1.0 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for isoxaflutole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.23 A5 Rat, 4 hr (whole body) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.02 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.05 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.012 A5 Rat, SF=167 -
Dermal penetration studies (%) 0.7-3 A5 concentration dependent -
Dangerous Substances Directive 76/464 List II - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptabe risk to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Possible liver toxicant
May damage corneal opacity
USEPA - probable human carcinogen
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H361d
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Reproduction risk category 3: R63
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S60, S61
WHO Classification NL - Not listed
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for isoxaflutole

Language Name
English isoxaflutole
French isoxaflutole
German Isoxaflutol
Danish isoxaflutol
Italian isoxaflutolo
Spanish isoxaflutol
Greek isoxaflutole
Slovenian izoksaflutol
Polish izoksaflutol
Swedish -
Hungarian izoxaflutol
Dutch isoxaflutole

Record last updated: Tuesday 25 June 2019
Contact: aeru@herts.ac.uk