Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!

mepanipyrim (Ref: KUF 6201)
** KIF 3535 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for mepanipyrim

Description: A fungicide used to control a wide range of fungal diseases mainly on salads and fruit.

Example pests controlled: Grey mould (Botryotinia fuckeliana); Scab

Example applications: Strawberries; Grapes; Blackberries; Raspberries; Tomatoes; Apples; Pears; Cucumber; Peppers; Aubergine

Efficacy & activity: Efficacy demonstrated via long term use and experimental field studies

Availability status: Current

Introduction & key dates: 1995

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Belgium/Greece
Date inclusion expires 30/04/2020
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C14H13N3
Canonical SMILES CC#CC1=CC(=NC(=N1)NC2=CC=CC=C2)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) CIFWZNRJIBNXRE-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H13N3/c1-3-7-13-10-11(2)15-14(17-13)16-12-8-5-4-6-9-12/h4-6,8-10H,1-2H3,(H,15,16,17)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide, Other susbtance
Other constituent type Bactericide, Wood preservative
Substance group Anilinopyrimidine
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier - toluene < 5g/kg
Substance origin Synthetic
Mode of action Non-systemic with preventative action. Inhibits protein synthesis.
CAS RN 110235-47-7
EC number 432-140-7
CIPAC number 611
US EPA chemical code 288203
PubChem CID 86296
Molecular mass (g mol-1) 223.27
PIN (Preferred Identification Name) -
IUPAC name N-(4-methyl-6-prop-1-ynylpyrimidin-2-yl)aniline
CAS name 4-methyl-N-phenyl-6-(1-propynyl)-2-pyrimidinamine
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 9
Examples of recorded resistance -
Physical state White crystals
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Certis
Example products using this active
  • Frupica SC
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as a soluble concentrate that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for mepanipyrim

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 2.08 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 139000 A5 - Acetone -
15400 A5 - Methanol -
102000 A5 - Ethyl acetate -
277000 A5 - Dichloromethane -
Melting point (oC) 132.8 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 288 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.91 X 1003 Calculated -
Log P 3.28 A5 High
Bulk density (g ml-1)/Specific gravity 1.205 A5 -
Dissociation constant (pKa) at 25oC 2.7 A5 -
Note: Strong acid
Vapour pressure at 20oC (mPa) 0.0232 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.67 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.28 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.22 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 344nm = 3170, 287nm = 29400; [Acidic solution: 358nm = 5020, 278nm = 28300; [Basic solution: 344nm = 3220, 287nm = 29800 A5 -
Surface tension (mN m-1) 72.0 A5 at 24 degC, 99.7% -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Not readily biodegradable
Soil degradation (days) (aerobic) DT50 (typical) 142.2 A5 Persistent
DT50 (lab at 20oC) 142.2 A5 Persistent
DT50 (field) 57 A5 Moderately persistent
DT90 (lab at 20oC) 582.5 A5 -
DT90 (field) 188 A5 -
DT50 modelling endpoint - - -
Note EU 2016 dossier Lab studies DT50 range 38.8-253.9 days, DT90 range 128.9->1000 days, Soils=4; EU 2001 dossier Lab studies DT50 range 46-191 days, DT90 range 152.9-636 days, field study DT50 range 34-75 days, DT90 range 114-249.3 days
Dissipation rate RL50 on plant matrix Value 4.7 R3 -
Note Tomato fruit, undercover, n=1
Dissipation rate RL50 on and in plant matrix Value 8.2 R4 -
Note Published literature RL50 range 3.6-12.8 days, 2 field & undercover grown crops, various matrices, n=2
Aqueous photolysis DT50 (days) at pH 7 Value 21.4 A5 Slow
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 7 to pH 9 under environmental conditions, DT50 57 days at pH 9, 70 deg C
Water-sediment DT50 (days) 14.5 A5 Fast
Water phase only DT50 (days) 7 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 44.88 A5 Slightly mobile
Kfoc 874
1/n 0.83
Notes and range EU dossier Kf range 6.32-159.8, Kfoc range 395-5859 mL/g, Soils=5
pH sensitivity Yes - increases as pH decreases

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
4-methyl-6-(1-propynyl)-pyrimidin-2-ylamine - Soil - -
1-(2-anilino-6-methylpyrimidin-4-yl)-2-propanone - Soil - -


ECOTOXICOLOGY

for mepanipyrim

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 280 A5 Threshold for concern
CT50 (days) 0.8 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 7.0 A5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 5620 ppm feed A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) > 0.74 A4 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.029 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.63 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.031 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 1.2 A4 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.23 A5 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 1.2 A4 Unknown species Low
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 50 A5 Moderate
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Bombus terrestris Low
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Bombus terrestris Low
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 57 A5 Eisenia foetida, corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 15 Beneficial capacity
Dose: 0.5 kg ha-1
A3 Typhlodromus pyri
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect -96 Beneficial capacity
Dose: 0.5 kg ha-1
A5 Trichogramma cacoeciae
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect [Dose 5.2 mg kg-1 soil]
Carbon mineralisation: No significant adverse effect
A5
Dose: 3.34 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for mepanipyrim

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 0.59 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.012 A5 Rat, SF=200 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) 0.1 A5 Rabbit, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.012 A5 Rat, SF=200 -
Dermal penetration studies (%) 0.4-13.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Possible liver & prostate toxicant
USEPA - probable human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H351
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 2: R41
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S46, S60, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for mepanipyrim

Language Name
English mepanipyrim
French mepanipyrim
German Mepanipyrim
Danish mepanipyrim
Italian mepanipirim
Spanish mepanipirina
Greek -
Slovenian mepanipirim
Polish mepanipyrim
Swedish mepanipyrim
Hungarian -
Dutch -

Record last updated: Tuesday 14 May 2019
Contact: aeru@herts.ac.uk