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nicosulfuron (Ref: DPX V9360)
** SL 950 ** MU 495 ** nicosulphuron ** DPX V9636 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for nicosulfuron

Description: A post-emergence herbicide used to control annual grass weeds in maize crops

Example pests controlled: Perennial grasses including Johnson grass (Sorghum halepense); Couch grass (Agropyron repens)

Example applications: Maize

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1990, first registered USA; 1992, launched France

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Latvia/Netherlands
Date inclusion expires 31/12/2019
EU Candidate for substitution (CfS) Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C15H18N6O6S
Canonical SMILES CN(C)C(=O)C1=C(N=CC=C1)S(=O)(=O)NC(=O)NC2=NC(=CC(=N2)OC)OC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) RTCOGUMHFFWOJV-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C15H18N6O6S/c1-21(2)13(22)9-6-5-7-16-12(9)28(24,25)20-15(23)19-14-17-10(26-3)8-11(18-14)27-4/h5-8H,1-4H3,(H2,17,18,19,20,23)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Sulfonylurea
Minimum active substance purity 930 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Selective, systemic absorbed by foliage and roots and translocated. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS
CAS RN 111991-09-4
EC number -
CIPAC number 709
US EPA chemical code 129008
PubChem CID 73281
Molecular mass (g mol-1) 410.41
PIN (Preferred Identification Name) -
IUPAC name 2-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-N,N-dimethylnicotinamide
CAS name 2-(((((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)-N,N-dimethyl-3-pyridinecarboxamide
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) B
Herbicide Resistance Classification (WSSA) 2
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Amaranthus hybridus
Bidens subalternans
Euphorbia heterophylla
Physical state White powder or colourless crystals
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Clayton
  • Delta Gamma Agro
  • Ellagret
  • ISK Biosciences
  • Standon
  • Syngenta
Example products using this active
  • Beliur 4 SC
  • Bucket 4 SC
  • Milagro
  • Samson
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as a soluble concentrate that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for nicosulfuron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 7500 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 8900 A5 - Acetone -
21300 A5 - Dichloromethane -
400 A5 - Methanol -
2400 A5 - Ethyl acetate -
Melting point (oC) 145 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 150 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 4.07 X 1000 Calculated -
Log P 0.61 A5 Low
Bulk density (g ml-1)/Specific gravity 0.31 L3 -
Dissociation constant (pKa) at 25oC 4.78 A5 -
Note: Weak acid; pKa (2) 7.58 Weak acid
Vapour pressure at 20oC (mPa) 8.00 X 10-07 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.48 X 10-11 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 3.25 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.38 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 244nm = 23800; [Acidic solution: 241nm = 19200; [Basic solution: 244nm = 23800 A5 -
Surface tension (mN m-1) 71.0 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 26 B5 Non-persistent
DT50 (lab at 20oC) 16.4 A5 Non-persistent
DT50 (field) 19.3 A5 Non-persistent
DT90 (lab at 20oC) 87.7 A5 -
DT90 (field) 87.1 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 5.7-40.4 days, DT90 range 23.4-154 days, field studies DT50 range 8.9-63.3 days, DT90 range 29.7-210 days; Other sources: DT50 24-43 days (R3), 21 days (F3)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 0.63 R3 -
Note Maize, grain, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 202 A5 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 7 and pH 9, DT50: 15 days at pH 5. Important degradation route under acid conditions.
Water-sediment DT50 (days) 41.5 A5 Moderately fast
Water phase only DT50 (days) 65 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - DW3 Mobile
Koc 30
Notes and range -
Freundlich Kf 0.29 A5 Mobile
Kfoc 21
1/n 0.93
Notes and range EU dossier kf range 0.05-0.73 mL/g, Kfoc range 7.9-51.3 mL/g, 1/n range 0.9-1.01; Other studies: Mean of 4 soils. Speyer 2.1 Kf=0.05; Speyer 2.2 Kf=0.2; Itingen II Kf=0.73; Les Evouettes Kf=0.19
pH sensitivity None, some correlation with soil clay content

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-(((4-hydroxy-6-methoxypyrimidin-2-yl)carbamoyl)sulfamoyl)-N,N-dimethylpyridine-3-carboxamide This metabolite may cause environmental pollution, click here for further information Soil   0.144   Major fraction, Relevancy unknown
2-((carbamimidoylcarbamoyl)sulfamoyl)-N,N-dimethylpyridine-3-carboxamide This metabolite may cause environmental pollution, click here for further information Soil   0.195   Major fraction, Relevant
N,N-dimethyl-2-sulfamoylpyridine-3-carboxamide This metabolite may cause environmental pollution, click here for further information Soil   0.215   Major fraction, Relevant
2-((carbamoylcarbamoyl)sulfamoyl)-N,N-dimethylpyridine-3-carboxamide Soil   0.085   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2-aminosulfonyl-N,N-dimethyl-3-pyridinecarboxyamide - Soil (Anaerobic) - -
2-amino-4,6-dimethoxyoyrimidine - Soil (Anaerobic) - -
methomyl
(Ref: OMS 1196)
Note: Minor fraction, Relevant
- Water (Photolysis) - -
1,1,1-acetonitrile
(Ref: USAF EK-488)
Note: Minor fraction, Relevant
- Water (Anaerobic) - -


ECOTOXICOLOGY

for nicosulfuron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A3 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 358 B5 Rat Moderate
(ppm diet) > 50000 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 1603 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 65.7 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 10.0 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 90.0 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 5.2 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.002 A5 Lemna gibba High
Non-target plants 0.47 A5 Rice
Vegetative vigour, ER50
as g/ha
-
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 7.8 A5 Anabaena flos-aquae Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 100 Q2 Unknown species Low
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 76 A5 Moderate
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 5.24 A4 Moderate
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 60 A5 Aphidius rhopalosiphi, adult -
% Effect 50.0 Mortality
Dose: 60 g ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 60 A5 Typhlodromus pyri, protonymph -
% Effect 50.0 Mortality
Dose: 60 g ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.08 mg kg-1 soil, 29 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for nicosulfuron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.47 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 2.0 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.8 A5 Dog, SF=100 x 40% -
Dermal penetration studies (%) 100 A3 default -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Negligible risk to bystanders
Occupational No unacceptable risks to operators or other farm workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E3

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues No further information available
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H315, H317
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification U - Unlikely to present an acute hazard
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for nicosulfuron

Language Name
English nicosulfuron
French nicosulfuron
German Nicosulfuron
Danish nicosulfuron
Italian nicosolfuron
Spanish nicosulfuron
Greek -
Slovenian nikosulfuron
Polish nikosulfuron
Swedish -
Hungarian nikoszulfuron
Dutch nicosulfuron

Record last updated: Tuesday 25 June 2019
Contact: aeru@herts.ac.uk