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oxamyl (Ref: DPX D1410)
** thioxamyl ** oxamil ** vydate ** dioxamyl ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Oxamyl is a carbamate pesticide currently approved for use in the EU. It is highly soluble in water, has a low volatility and may have the capacity to leach to groundwater. It is not expected to be persistent in soil or water systems. It is highly toxic to mammals, is a cholinesterase inhibitor and a neurotoxicant. Oxamyl is not expectd to accumulate in soils. It demonstrates a moderate to high level of toxicity to most biodiversity.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for oxamyl

Description: A soil-applied nematicide and insecticide used to control chewing and sucking insects on field and other crops

Example pests controlled: Aphids; Spider mites; Ticks; Roundworms; Nematodes including Globodera and Heterodera sp., Trichodorus and Paratrichodorus sp., Radopholus similis, Ditylenchus sp.

Example applications: Field crops; Vegetables including carrots, cucubits and celery; Tobacco; Potatoes; Fruit including apples, bananas, citrus, tomatoes; Cotton; Ornamentals;

Efficacy & activity: Shown to be effective in field trials

Availability status: Current

Introduction & key dates: 1974, first sold

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Italy/France
Date inclusion expires 31/01/2020
EU Candidate for substitution (CfS) Yes - low ADI / ARfD / AOEL
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Isomeric
Chemical formula C7H13N3O3S
Canonical SMILES CNC(=O)ON=C(C(=O)N(C)C)SC
Isomeric SMILES CNC(=O)O/N=C(/C(=O)N(C)C)\SC
International Chemical Identifier key (InChIKey) KZAUOCCYDRDERY-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C7H13N3O3S/c1-8-7(12)13-9-5(14-4)6(11)10(2)3/h1-4H3,(H,8,12)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Acaricide, Nematicide
Substance group Carbamate
Minimum active substance purity 970 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic with contact action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 23135-22-0
EC number 245-445-3
CIPAC number 342
US EPA chemical code 103801
PubChem CID 9595287
Molecular mass (g mol-1) 219.26
PIN (Preferred Identification Name) -
IUPAC name (EZ)-N,N-dimethyl-2-methylcarbamoyloxyimino-2-(methylthio)acetamide
CAS name methyl 2-(dimethylamino)-N-(((methylamino)carbonyl)oxy)-2-oxoethanimidothioate
Other status information Marine Pollutant; Possible drinking water contaminant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Anthonomus grandis
Diglyphus begini
Ganaspidium utilis
Leptinotarsa decemlineata
Lygus lineolaris
Phyllonorycter blancardella
Physical state Colourless or white crystalline powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • DuPont
  • Agchem Access
Example products using this active
  • Vydate 10G
  • Tevday
UK LERAP status None
Formulation and application details Often supplied as granules or water-soluble liquid that is applied directly to the soil before drilling or planting.


ENVIRONMENTAL FATE

for oxamyl

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 148100 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 10500 A5 - n-Heptane -
250000 A5 - Methanol -
250000 A5 - Acetone -
41300 A5 - Xylene -
Melting point (oC) 98.5 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 165 A5 -
Flashpoint (oC) 57.4 A5 -
Octanol-water partition coefficient at pH 7, 20oC P 3.63 X 10-01 Calculated -
Log P -0.44 A5 Low
Bulk density (g ml-1)/Specific gravity 1.31 A5 -
Dissociation constant (pKa) at 25oC -2.11 A5 -
Note: Estimated, Very strong acid
Vapour pressure at 20oC (mPa) 0.018 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.7 X 10-08 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.08 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 4.65 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 290nm = 80.1; [Acidic solution: 290nm = 60.1; [Basic solution: 290nm = 1154 A5 -
Surface tension (mN m-1) 73.1 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Not readily biodegradable
Soil degradation (days) (aerobic) DT50 (typical) 5.3 A5 Non-persistent
DT50 (lab at 20oC) 5.3 A5 Non-persistent
DT50 (field) 6.0 A5 Non-persistent
DT90 (lab at 20oC) 22 A5 -
DT90 (field) 36 A5 -
DT50 modelling endpoint - - -
Note EU 2017 dossier lab studies DT50 (normalised) range 0.6-19.4 days, DT90 (not normalised) range 9.9-38.2 days, Soils = 9; field studies DT50 (normalised) range 5.0-6.9, Soils =2
Dissipation rate RL50 on plant matrix Value 2.7 R3 -
Note Cotton, n=1
Dissipation rate RL50 on and in plant matrix Value 8.9 R4 -
Note Published literature RL50 range 2.9-15.0 days, 2 crops undercover/lab, various matrices, n=2
Aqueous photolysis DT50 (days) at pH 7 Value 3.5 A5 Moderately fast
Note at pH 5, 20 degC
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 21.1 A5 Non-persistent
Note pH sensitive: Stable @ pH 4; DT50 = 0.2 days @ pH 9
Water-sediment DT50 (days) 0.7 A5 Fast
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 0.24 A5 Very mobile
Koc 14.91
Notes and range EU 2017 dossier Kd range 0.6-19.4 mL/g, Koc range 4.3-39.0 mL/g, Soils=11
Freundlich Kf 0.22 A5 Very mobile
Kfoc 13.59
1/n 0.92
Notes and range EU 2017 dossier kf range 0.05-0.598 mL/g, Kfoc range 4.1-37.0 mL/g, 1/n range 0.66-1.08, Soils=11
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
methyl 2-(dimethylamino)-N-(((methylamino)carbonyl)oxy)-2-oxoethanimidothioate (Ref: IN-A2213) This metabolite may cause environmental pollution, click here for further information Soil   0.510   Major fraction, Relevant
N,Ní-dimethyloxamic acid (Ref: IN-D2708) This metabolite may cause environmental pollution, click here for further information Soil   0.780   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
methyl 2-(dimethylamino)-N-hydroxy-2-oxoethanimidothioate - Soil (Anaerobic) - -
N,N-dimethyl-1-cyanoformamid
(Ref: IN-D0079)
DMCF Soil; Water/sediment - -
(Ref: IN-L2953) - Rat - -
N,N-dimethylethanediamide
(Ref: IN-T2921)
DMEA; DOA Water/sediment - -


ECOTOXICOLOGY

for oxamyl

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 2 P4 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 2.5 A5 Rat High
Mammals - Short term dietary NOEL (mg kg-1) 0.93 A5 Dog, 1 year High
(ppm diet) 33 -
Birds - Acute LD50 (mg kg-1) 3.16 A5 Anas platyrhynchos High
Birds - Short term dietary (LC50/LD50) 340 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 3.13 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.5 A4 Pimephales promelas, 28 day Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.319 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.027 A4 Unknown species Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 3.57 A5 Lemna gibba Moderate
Non-target plants > 2.24 A5 Zea mays, Avena sativa, Allium cepa, Lolium perenne, Cucumis sativus, Brassica napus
ER50, vegetative vigour
as kg/ha
-
> 2.24 A5 Zea mays, Avena sativa, Allium cepa, Lolium perenne, Cucumis sativus, Brassica napus
ER50, Seedling emergence
as kg/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 0.93 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.5 Q2 Unknown species Moderate
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.47 A5 Apis meliifera High
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.38 A5 Apis meliifera High
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 39.3 A5 Bombus terrestris Moderate
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.36 A5 Bombus terrestris High
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 112 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 6.4 A5 Eisenia foetida, 56 day Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 0.03 48 hour
A5 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 1.8 7 day
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect [Dose: 5 mg kg-1 soil]
Carbon mineralisation: No significant adverse effect [Dose: 10 mg kg-1 soil]
A5 -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for oxamyl

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 2.5 A5 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.056 A5 Rat (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.001 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.001 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.01 A5 Rat, SF=100 -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational Negligible risk to operators
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Harmful if ingested
Endocrine issues - weak estrogen effect
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Corrosive
Not explosive or oxidising
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H226, H300, H312, H319, H330
Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases T+ - Very toxic: R26/28
Xn - Harmful: E21
N - Dangerous for the environment: R51, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S36/37, S45, S61
WHO Classification Ib - Highly hazardous
UN Number Usually 2757
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group II (medium danger)


TRANSLATIONS

for oxamyl

Language Name
English oxamyl
French oxamyl
German Oxamyl
Danish oxamyl
Italian oxamil
Spanish oxamilo
Greek -
Slovenian oksamil
Polish oksamyl
Swedish -
Hungarian oxamil
Dutch oxamyl

Record last updated: Wednesday 26 June 2019
Contact: aeru@herts.ac.uk