Permethrin is a contact insecticide. It is not highly soluble in water, has a low volatility and is not normally expected to leach to groundwater. It would also not be expected to persist in soil or water systems. It is moderately toxic to humans, is an irritant and may be a CNS toxicant. It is highly toxic to most aquatic species and honeybees but is not highly toxic to birds or earthworms.
Data alerts
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Environmental fate Moderate alert: Moderately persistent; Potential for particle bound transport: Medium
Ecotoxicity High alert: Fish acute ecotoxicity: High; Fish chronic ecotoxicity: High; Daphnia acute ecotoxicity: High; Bees acute contact ecotoxicity: High; Bees acute oral ecotoxicity: High
Human health High alert: Endocrine disrupter; Reproduction/development effects; Neurotoxicant
GENERAL INFORMATION
Description
An insecticide active against a wide range of pests including Lepidoptera and Coleoptera in crops and various animal ectoparasites
Example pests controlled
Cockroaches; Termites; Ticks; Mosquitoes; Aphids; Fleas; Ants
Colourless crystalline solid to brown viscous liquid depending upon purity
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
Agropharm
ICI Plant Protection
Mitchell Cotts
FMC
BOC Sciences
Example products using this active
Fortefog P Fumer
Ambush
Exmin
Kestril
Ectiban
Pynosect
Corsair
Arctic
Formulation and application details
Available in a variety of formulations including fumigants, shampoos and spot-on treatments
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
0.011
E4 E = Manufacturers safety data sheets 4 = Verified data
Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)
1000000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Hexane
-
258000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Methanol
-
1000000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Xylene
-
Melting point (°C)
34.5
E4 E = Manufacturers safety data sheets 4 = Verified data
-
Boiling point (°C)
465.9
E4 E = Manufacturers safety data sheets 4 = Verified data
-
Degradation point (°C)
-
-
-
Flashpoint (°C)
159.4
E4 E = Manufacturers safety data sheets 4 = Verified data
-
Octanol-water partition coefficient at pH 7, 20 °C
P
1.26 X 1006
Calculated
-
Log P
6.1
G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data
High
Fat solubility of residues
Solubility
Soluble
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
-
Data type
Regulatory data - observed in metabolism and farm animal feeding studies
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
-
Density (g ml⁻¹)
1.19
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
-
Dissociation constant pKa) at 25 °C
-
-
-
-
Vapour pressure at 20 °C (mPa)
0.007
R4 R = Peer reviewed scientific publications 4 = Verified data
at 25°C
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
1.89 X 10-01
H4 H = The US ARS pesticide properties database. Dataset is no longer available. 4 = Verified data
Moderately volatile
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
-
-
-
Surface tension (mN m⁻¹)
-
-
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
13
K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data
Non-persistent
DT₅₀ (lab at 20 °C)
13
K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data
Non-persistent
DT₅₀ (field)
42
H4 H = The US ARS pesticide properties database. Dataset is no longer available. 4 = Verified data
Moderately persistent
DT₉₀ (lab at 20 °C)
-
-
-
DT₉₀ (field)
-
-
-
DT₅₀ modelling endpoint
-
-
-
Note
-
Dissipation rate RL₅₀ on plant matrix
Value
6.7
R4 R = Peer reviewed scientific publications 4 = Verified data
-
Note
Published literature RL₅₀ range 2.5-20.0 days, 8 field & undercover grown crops, various matrices, n=9
Dissipation rate RL₅₀ on and in plant matrix
Value
11.1
R4 R = Peer reviewed scientific publications 4 = Verified data
-
Note
Published literature RL₅₀ range 9.5-13.9 days, 3 field & undercover grown crops, various matrices, n=3
Aqueous photolysis DT₅₀ (days) at pH 7
Value
1
K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data
Moderately fast
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
31
K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data
Moderately persistent
Note
-
Water-sediment DT₅₀ (days)
40
K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data
Moderately fast
Water phase only DT₅₀ (days)
23
K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data
Slow
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
-
G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data
Non-mobile
Koc
100000
Notes and range
-
Freundlich
Kf
1.87
R4 R = Peer reviewed scientific publications 4 = Verified data
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
5.35 X 10-03
Calculated
-
Note
Estimated concentrations of chemicals with Koc values greater than 9995 ml g⁻¹ are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index
Medium
Calculated
-
Potential for loss via drain flow
Non-mobile
Calculated
-
Bio-concentration factor
BCF (l kg⁻¹)
300
P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data
(Other literature Log BCF range 1.4-3.3 (R3))
Threshold for concern
CT₅₀ (days)
Not available
-
Known metabolites
None
ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 430
G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data
Rat
Moderate
Mammals - Short term dietary NOEL
(mg kg⁻¹)
-
L2 L = Pesticide manuals and hard copy reference books / other sources 2 = Unverified data of unknown source
Rat 2 year
-
(ppm diet)
100
-
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
-
-
-
Birds - Acute LD₅₀ (mg kg⁻¹)
> 9800
G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data
Anas platyrhynchos
Low
Birds - Short term dietary (LC₅₀/LD₅₀)
-
-
-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
-
-
-
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
1440
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Low
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
-
-
-
Soil micro-organisms
-
-
-
Collembola
Acute LC₅₀ (mg kg⁻¹)
-
-
-
Chronic NOEC (mg kg⁻¹)
-
-
-
Non-target plants
-
-
-
-
-
-
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Daphnia magna
High
Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
-
-
-
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
0.00002
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
-
-
-
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
0.0125
K3 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 3 = Unverified data of known source
Unknown species
Moderate
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
0.0009
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source
Unknown species
High
Mesocosm study data
NOEAEC mg l⁻¹
-
-
-
NOEAEC mg l⁻¹
-
-
-
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III)
-
-
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 430
G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data
Non-statutory WHO drinking water guideline 0.3 mg l⁻¹
B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes
UK EA QS database 2018
-
Drinking Water MAC (μg l⁻¹)
-
-
-
Mammalian dose elimination route and rate
Rapidly metabolised by ester hydrolysis to inactive metabolites which are excreted primarily in the urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
?Possibly, status not identified
A3 A = Chromosome aberration (EFSA database) 3 = Negative
;
B0 B = DNA damage/repair (EFSA database) 0 = No data
;
C0 C = Gene mutation (EFSA database) 0 = No data
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
✓Yes, known to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
?Possibly, status not identified
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Eye irritant
Phototoxicant
✓Yes, known to cause a problem
No data found
General human health issues
Harmful Estrogenic IARC Group 3 carcinogen - not classifiable; USEPA - probable human carcinogen Endocrine issues - Inhibition of estrogen-sensitive cells proliferation
Handling issues
Property
Value and interpretation
General
IMDG Transport Hazard Class 6.1
CLP classification 2013
Health: H302, H332, H335 Environment: H400, H410
WHO Classification
II (Moderately hazardous)
UN Number
UN3077
Waste disposal & packaging
Packaging Group III (minor danger)
Shelf-life, storage, stability and reactivity
Chemically stable under standard ambient conditions. Shelf-life of 2 yrs. Store -20 DegC in an inert atmosphere
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242
Environmental fate
Ecotoxicity
