| profenofos (Ref: OMS 2004) |
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Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for profenofos
Description: An insecticide used on a wide variety of crops to control many pests but mainly Lepidoptera and mites
Example pests controlled: Aphids; Lygus bugs; Cotton bollworm; Tobacco bud worm; Leaf webber; Cotton leaf-perforator; Beet armyworm; Whitefly (suppression); Spidermites; Caterpillars
Example applications: Cotton; Maize; Tobacco; Sugarbeet; Soybeans; Potatoes; Ornamentals including jasmine.
Efficacy & activity: -
Availability status: Current
Introduction & key dates: 1975, first reported
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | Not applicable |
| Date inclusion expires | Expired |
| EU Candidate for substitution (CfS) | - |
| Listed in EU database | Yes |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Australia
Chemical structure:
| Isomerism | A molecule with one chiral feature - 2 steroisomers. |
| Chemical formula | C11H15BrClO3PS |
| Canonical SMILES | CCCSP(=O)(OCC)OC1=C(C=C(C=C1)Br)Cl |
| Isomeric SMILES | No data |
| International Chemical Identifier key (InChIKey) | QYMMJNLHFKGANY-UHFFFAOYSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C11H15BrClO3PS/c1-3-7-18-17(14,15-4-2)16-11-6-5-9(12)8-10(11)13/h5-6,8H,3-4,7H2,1-2H3 |
| 2D structure diagram/image available? | Yes |
General status:
| Pesticide type | Insecticide, Acaricide | |
| Substance group | Organophosphate | |
| Minimum active substance purity | - | |
| Known relevant impurities | - | |
| Substance origin | Synthetic | |
| Mode of action | Non-systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor. | |
| CAS RN | 41198-08-7 | |
| EC number | 255-255-2 | |
| CIPAC number | 461 | |
| US EPA chemical code | 111401 | |
| PubChem CID | 38779 | |
| Molecular mass (g mol-1) | 373.63 | |
| PIN (Preferred Identification Name) | - | |
| IUPAC name | (RS)-(O-4-bromo-2-chlorophenyl O-ethyl S-propyl phosphorothioate) | |
| CAS name | O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate | |
| Other status information | PAN listed Highly Hazardous Chemical | |
| Relevant Environmental Water Quality Standards | - | |
| Herbicide Resistance Classification (HRAC) | Not applicable | |
| Herbicide Resistance Classification (WSSA) | Not applicable | |
| Insecticide Resistance Classification (IRAC) | 1B | |
| Fungicide Resistance Classification (FRAC) | Not applicable | |
| Examples of recorded resistance | Bemisia tabaci Chrysoperla carnea Earias vittella Leucoptera meyricki Spodoptera littoralis Tetranychus urticae many others |
|
| Physical state | Pale yellow liquid | |
| Related substances & organisms | ||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | No UK approval for use as a pesticide under EC Regulation 1107/2009 | |||
| Formulation and application details | - | |||
ENVIRONMENTAL FATE
for profenofos
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 28 | H4 | Low | |
| Solubility - In organic solvents at 20oC (mg l-1) | Miscible | L2 - Acetone | - | |
| Miscible | L2 - Methanol | - | ||
| Miscible | L2 - Xylene | - | ||
| Melting point (oC) | Not applicable | L3 | - | |
| Boiling point (oC) | - | - | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | 124 | L3 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 5.01 X 1001 | Calculated | - |
| Log P | 1.7 | H4 | Low | |
| Bulk density (g ml-1)/Specific gravity | 1.46 | L3 | - | |
| Dissociation constant (pKa) at 25oC | Not applicable | L3 | - | |
| Note: No dissociation | ||||
| Vapour pressure at 20oC (mPa) | 2.53 | H4 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 1.65 X 10-03 | L3 | Non-volatile | |
GUS leaching potential index  |
0.59 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 6.87 X 10-03 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Medium | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 7 | L3 | Non-persistent |
| DT50 (lab at 20oC) | 7 | L3 | Non-persistent | |
| DT50 (field) | 7 | L3 | Non-persistent | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| DT50 modelling endpoint | - | - | - | |
| Note: | - | |||
| Dissipation rate RL50 on plant matrix | Value | 1.6 | R4 | - |
| Note | Published literature RL50 range 1.0-2.0 days, 6 field & undercover grown crops, various matrices, n=9 | |||
| Dissipation rate RL50 on and in plant matrix | Value | 5.4 | R4 | - |
| Note | Published literature RL50 range 1.0-41.0 days, 6 field crops, various matrices, n=14 | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | - | - | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | Stable | W4 | - |
| Note | Other data: DT50 93 days at pH 5, 14.6 days at pH 7, 5.7 hours at pH 9, all at 20 degC (L3) | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | H3 | Slightly mobile |
| Koc | 2016 | |||
| Notes and range | Best available data | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 1186 | Q2 Estimated | Threshold for concern |
| CT50 (days) | Not available | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 358 | L3 Rat | Moderate | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | L2 Rat, 2 year | - |
| (ppm diet) | 0.3 | - | ||
| Birds - Acute LD50 (mg kg-1) | 70 | L3 Coturnix japonica | High | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 0.08 | L3 Oncorhynchus mykiss | High | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 0.5 | F4 Daphnia magna | Moderate | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | 0.0016 | F3 Americamysis bahia | High | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | - | - | - | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees (Apis spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | 0.095 | F4 | High |
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Bumblebees (Bombus spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| - | ||||
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| - | ||||
| Mason bees (Osmia spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Other pollinators (1) | Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) | - | - | - |
| Mode of exposure | - | |||
| Other pollinators (2) | Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) | - | - | - |
| Mode of exposure | - | |||
| Earthworms - Acute 14 day LC50 (mg kg-1) | - | - | - | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for profenofos
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 358 | L3 Rat | Moderate | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | 472 | L3 Rabbit | - | |
| Mammals - Inhalation LC50 (mg l-1) | 3.0 | L3 Rat | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.03 | JMPR 2007 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | 1.0 | JMPR 2007 | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | List I; List II | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | - | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Genotoxic | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
|
A3; B0; C0; D0; E0 | - |
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Harmful by inhalation | |||||||
| Key: Genotoxicity A: Chromosome aberration (EFSA database) B: DNA damage/repair (EFSA database) C: Gene mutation (EFSA database) D: Genome mutation (EFSA database) E: Unspecified genotoxicity type (miscellaneous data source) 0: No data 1: Positive 2: Mixed/ambiguous results 3: Negative |
Key: Other : Yes, known to cause a problem  : No, known not to cause a problem  : Possibly, status not identified - : No data found |
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Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
No information available | |||
| CLP classification 2013 | Health: H302, H312, H332 Environment: H400, H410 |
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| EC Risk Classification |
Xn - Harmful: R20/21/22 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S2, S36/37, S60, S61 | |||
| WHO Classification | II | - | Moderately hazardous | |
| UN Number | 3018 | |||
| Waste disposal & packaging |
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| Language | Name |
| English | profenofos |
| French | profenophos |
| German | Profenofos |
| Danish | profenofos |
| Italian | profenfos |
| Spanish | profenofos |
| Greek | profenofos |
| Slovenian | profenofos |
| Polish | profenofos |
| Swedish | - |
| Hungarian | - |
| Dutch | profenofos |
Record last updated: Tuesday 02 July 2019
Contact: aeru@herts.ac.uk