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GET ADDITIONAL DATA HERE!
prohexadione-calcium (Ref: BAS 125W)
** KUH 833 ** KIM 112 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for prohexadione-calcium

Description: A plant growth regulator used as an anti-lodging agent in small-grain cereals and to reduce vegetative growth in other crops

Example pests controlled: Growth

Example applications: Cereals including barley, oats and wheat; Turf; Apples; Pears; Peanuts

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1994

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur France/Ireland
Date inclusion expires 31/12/2021
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C20H22CaO10
Canonical SMILES CCC(=C1C(=O)CC(CC1=O)C(=O)[O-])[O-].[Ca+2]
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) QKWLAUAUUGXSSE-UHFFFAOYSA-L
International Chemical Identifier (InChI) InChI=1S/2C10H11O5.Ca/c2*1-2-6(11)9-7(12)3-5(10(14)15)4-8(9)13;/h2*5H,2-4H2,1H3,(H,14,15);/q2*-1;+2
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Plant growth regulator
Substance group Unclassified
Minimum active substance purity 928 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Growth retardent
CAS RN 127277-53-6
EC number 603-193-5
CIPAC number 567.020
US EPA chemical code 112600
PubChem CID 12001831
Molecular mass (g mol-1) 462.46
PIN (Preferred Identification Name) -
IUPAC name calcium 3-oxido-5-oxo-4-propionylcyclohex-3-enecarboxylate
CAS name calcium 3-oxido-5-oxo-4-propionylcyclohexa-3-enecarboxylate
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
Example products using this active
  • Regalis
  • Medax Top
UK LERAP status None
Formulation and application details Often supplied as a wettable granules or as soluble concentrate that are mixed with water and used as a spray.


ENVIRONMENTAL FATE

for prohexadione-calcium

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 786 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 0.01 A5 - Ethyl acetate -
0.038 A5 - Acetone -
0.003 A5 - Hexane -
1.11 A5 - Methanol -
Melting point (oC) 360 A5 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.26 X 10-03 Calculated -
Log P -2.9 A5 Low
Bulk density (g ml-1)/Specific gravity 1.46 L3 -
Dissociation constant (pKa) at 25oC 5.15 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 1.33 X 10-02 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.92 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.76 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.21 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 No absorption >290nm;[Neutral solution: 273nm = 15400 A5 -
Surface tension (mN m-1) 72.6 A5 at 20oC, 97.5% -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 0.7 Click here to see a warning relating to modelling and this active substance A5 Non-persistent
DT50 (lab at 20oC) 0.66 A5 Non-persistent
DT50 (field) 11 F3 Non-persistent
DT90 (lab at 20oC) 8.2 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 0.2-2.9 days, DT90 range 0.7-39 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 4 C2 Moderately fast
Note DT50 6.3 days natural water, 2.7 days distilled water
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 66 A5 Moderately persistent
Note pH sensitive: pH4 = 2.5 days, pH5 = 3.2 days, pH7 = 66 days, pH9 = Stable all at 25 degC
Water-sediment DT50 (days) 1.8 A5 Fast
Water phase only DT50 (days) 1.8 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 5.1 A5 Moderately mobile
Kfoc 204.5
1/n 1.00
Notes and range EU dossier Kf range 0.49-10.12, Kfoc range 82-307 mL/g, 1/n range 0.93-1.04, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
despropionyl prohexadione (Ref: KI5376) This metabolite may cause environmental pollution, click here for further information Soil   0.152   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
tricarballyic acid - Soil - -
citric acid - Water - -
unknown BX-112-M-10 Water - -
tricarballyic acid - Soil - -
citric acid - Water - -
unknown BX-112-M-10 Water - -
tricarballyic acid - Soil - -
citric acid - Water - -
unknown BX-112-M-10 Water - -


ECOTOXICOLOGY

for prohexadione-calcium

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 93.9 L2 Rat, 2 year High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 1214 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 100 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 100 A5 Oncorhynchus mykiss Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 100 A5 Daphnia carinata Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 100 A5 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 1.2 A5 Lemna gibba Moderate
Non-target plants > 1.5 A5 Avena sativa, Allium cepa, Brassica napus
Vegetative vigour, ER50
as L product/ha (Regalis: Conc 100g/kg)
-
> 1.5 A5 Avena sativa, Allium cepa, Brassica napus
Seedling emergence, ER50
as L product/ha (Regalis: Conc 100g/kg)
-
Algae - Acute 72 hour EC50, growth (mg l-1) > 100 A5 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Apis mellifera Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Apis mellifera Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 5000 as g product ha-1 (Regalis: Conc 100g/kg)
A5 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 7500 as g product ha-1 (Regalis: Conc 100g/kg))
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.69 mg kg-1, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for prohexadione-calcium

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 4.21 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.2 BA5; EU 2000 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated BA5; EU 2000 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.35 BA5; EU 2000 -
Dermal penetration studies (%) 10-30 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public No unacceptable risks identified
Occupational No unacceptable risks identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E0

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Possible kidney toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Environment: H411, H412
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R52/53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S13, S20/21, S35, S57
WHO Classification NL - Not listed
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for prohexadione-calcium

Language Name
English prohexadione-calcium
French prohexadione-calcium
German Prohexadion
Danish prohexadion-calcium
Italian calcio-proesadione
Spanish prohexadiona-calcica
Greek -
Slovenian proheksadion-kalcij
Polish proheksadion wapnia
Swedish prohexadionkalcium
Hungarian prohexadion
Dutch -

Record last updated: Friday 08 November 2019
Contact: aeru@herts.ac.uk