| propazine (Ref: G 30028) |
 |
Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for propazine
Description: A chlorotriazine herbicide used for control of broad-leaved weeds and annual grasses
Example pests controlled: Annual morning glory; Pigweed; Smartweed; Carpet weed; Lambsquarter; Ragweed; Velvetleaf
Example applications: Sorghum; Corn; Some umbelliferae vegetables; Carrots; Fennel; Ornamentals; Greenhouse use
Efficacy & activity: -
Availability status: Current
Introduction & key dates: 1998, USA
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | - |
| Date inclusion expires | Expired |
| EU Candidate for substitution (CfS) | - |
| Listed in EU database | Yes |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Australia
Chemical structure:
| Isomerism | - |
| Chemical formula | C9H16ClN5 |
| Canonical SMILES | CC(C)NC1=NC(=NC(=N1)Cl)NC(C)C |
| Isomeric SMILES | No data |
| International Chemical Identifier key (InChIKey) | WJNRPILHGGKWCK-UHFFFAOYSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C9H16ClN5/c1-5(2)11-8-13-7(10)14-9(15-8)12-6(3)4/h5-6H,1-4H3,(H2,11,12,13,14,15) |
| 2D structure diagram/image available? | Yes |
General status:
| Pesticide type | Herbicide | |||
| Substance group | Triazine | |||
| Minimum active substance purity | - | |||
| Known relevant impurities | - | |||
| Substance origin | Synthetic | |||
| Mode of action | Selective, systemic, absorbed by roots and translocated | |||
| CAS RN | 139-40-2 | |||
| EC number | 205-359-9 | |||
| CIPAC number | 92 | |||
| US EPA chemical code | 080808 | |||
| PubChem CID | 4937 | |||
| Molecular mass (g mol-1) | 229.71 | |||
| PIN (Preferred Identification Name) | - | |||
| IUPAC name | 6-chloro-N2,N4-diisopropyl-1,3,5-triazine-2,4-diamine | |||
| CAS name | 6-chloro-N,N'-bis(1-methylethyl)-1,3,5-triazine-2,4-diamine | |||
| Other status information | Marine pollutant | |||
| Relevant Environmental Water Quality Standards | - | |||
| Herbicide Resistance Classification (HRAC) | C1 | |||
| Herbicide Resistance Classification (WSSA) | - | |||
| Insecticide Resistance Classification (IRAC) | Not applicable | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Examples of recorded resistance | - | |||
| Physical state | Colourless crystalline solid | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | No UK approval for use as a pesticide under EC Regulation 1107/2009 | |||
| Formulation and application details | Often supplied as water-dispersible granules or wettable powder. | |||
ENVIRONMENTAL FATE
for propazine
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 8.6 | K4 | Low | |
| Solubility - In organic solvents at 20oC (mg l-1) | 6200 | L3 - Benzene | - | |
| 5000 | L3 - Diethyl ether | - | ||
| 2500 | L3 - Carbon tetrachloride | - | ||
| Melting point (oC) | 213 | L3 | - | |
| Boiling point (oC) | - | - | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | - | - | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 8.91 X 1003 | Calculated | - |
| Log P | 3.95 | K4 | High | |
| Bulk density (g ml-1)/Specific gravity | 1.16 | L3 | - | |
| Dissociation constant (pKa) at 25oC | 1.7 | L3 | - | |
| Note: Very weak base | ||||
| Vapour pressure at 20oC (mPa) | 0.004 | G4 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 1.79 X 10-04 | L3 | Non-volatile | |
GUS leaching potential index  |
3.86 | Calculated | High leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 1.07 X 10+00 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Medium | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 131 | K4 | Persistent |
| DT50 (lab at 20oC) | 135 | F3 | Persistent | |
| DT50 (field) | - | - | - | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | Best available data | |||
| Dissipation rate RL50 on plant matrix | Value | - | - | - |
| Note | - | |||
| Dissipation rate RL50 on and in plant matrix | Value | - | - | - |
| Note | - | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | 0.8 | K3 | Fast |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 83 | K3 | Moderately persistent |
| Note | Stable under normal environmental conditions, hydrolysed by acids and alkalis at elevated temperatures | |||
| Water-sediment DT50 (days) | 77 | K4 | Moderately fast | |
| Water phase only DT50 (days) | 77 | K4 | Stable | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | G3 | Moderately mobile |
| Koc | 154 | |||
| Notes and range | Best available data | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
Key metabolites:
| Metabolite | Formation medium | Estimated maximum occurrence fraction | 1107/2009 relevancy |
|
| hydroxypropazine | Soil | - | - | |
Other known metabolites:
| Metabolite name and reference | Aliases | Formation medium / Rate | Estimated maximum occurrence fraction | Metabolising enzymes |
| 2-hydroxy-4,6-bis(isopropylamino)-s-triazine | - | Soil (Aerobic); Water (Photolysis) | - | - |
| 4,6-bis(isopropylamino)-s-triazine | - | Soil (Aerobic) | - | - |
| 2-chloro-4-amino-6-isopropylamino-s-triazine | - | Soil (Aerobic & Anaerobic) | - | - |
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 62 | Q2 Estimated | Low potential |
| CT50 (days) | Not available | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 3840 | G4 Rat | Low | |
| Mammals - Short term dietary NOEL | (mg kg-1) | 13 | L3 Rat | High |
| (ppm diet) | 200 | - | ||
| Birds - Acute LD50 (mg kg-1) | > 10000 | L3 Anas platyrhynchos | Low | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | > 17.5 | L3 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | > 17.7 | K2 Unknown species | Moderate | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | 0.88 | F3 Lemna gibba | Moderate | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | 0.18 | F3 Cyanobacteria | Moderate | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees (Apis spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | 16 | K4 | Moderate |
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Bumblebees (Bombus spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| - | ||||
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| - | ||||
| Mason bees (Osmia spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Other pollinators (1) | Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) | - | - | - |
| Mode of exposure | - | |||
| Other pollinators (2) | Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) | - | - | - |
| Mode of exposure | - | |||
| Earthworms - Acute 14 day LC50 (mg kg-1) | - | - | - | |
| Earthworms - Chronic NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms | Acute LC50 (mg kg-1) | - | - | - | Chronic NOEC (mg kg-1) | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for propazine
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 3840 | G4 Rat | Low | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | > 3100 | L3 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | 2.04 | L3 Rabbit | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | - | - | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | - | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | - | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Genotoxic | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
|
A0; B0; C0; D0; E3 |
|
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- |
- |
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Endocrine issues - Induction of aromatase activity and increase of estrogen production | |||||||
| Key: Genotoxicity A: Chromosome aberration (EFSA database) B: DNA damage/repair (EFSA database) C: Gene mutation (EFSA database) D: Genome mutation (EFSA database) E: Unspecified genotoxicity type (miscellaneous data source) 0: No data 1: Positive 2: Mixed/ambiguous results 3: Negative |
Key: Other : Yes, known to cause a problem  : No, known not to cause a problem  : Possibly, status not identified - : No data found |
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Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
No information available | |||
| CLP classification 2013 | Health: H351 Environment: H400, H410 |
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| EC Risk Classification |
Carcinogen category 3: R40 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S2, S36/37, S60, S61 | |||
| WHO Classification | U | - | Unlikely to present an acute hazard | |
| UN Number | - | |||
| Waste disposal & packaging |
Packaging Group III (minor danger) | |||
| Language | Name |
| English | propazine |
| French | propazine |
| German | Propazin |
| Danish | propazin |
| Italian | propazina |
| Spanish | propazina |
| Greek | - |
| Slovenian | propazin |
| Polish | propazyna |
| Swedish | - |
| Hungarian | - |
| Dutch | propazine |
Record last updated: Wednesday 27 November 2019
Contact: aeru@herts.ac.uk