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GET ADDITIONAL DATA HERE!

propineb (Ref: BAY 46131)
** propinebe ** methyl-metiram ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for propineb

Description: A foliar-applied fungicide with long residual activity used on a wide range of agricultural crops

Example pests controlled: Downy mildew; Black rots; Grey moulds; Scab; Leaf spots; Blossom wilt

Example applications: Grapes; Tomatoes; Potatoes; Pome fruit; Onions; Melons; bell peppers

Efficacy & activity: Propineb has been tested in field development trials which demonstrated efficacious activity.

Availability status: Current

Introduction & key dates: 1965, first introduced

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Italy/Romania
Date inclusion expires Expired
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A molecule with one chiral feature.
Chemical formula C5H8N2S4Zn
Canonical SMILES CC(CNC(=S)[S-])NC(=S)[S-].[Zn+2]
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) HLQULFUYWRYRJQ-UHFFFAOYSA-M
International Chemical Identifier (InChI) InChI=1S/C5H10N2S4.Zn/c1-3(7-5(10)11)2-6-4(8)9;/h3H,2H2,1H3,(H2,6,8,9)(H2,7,10,11);/q;+2/p-2/rC5H8N2S4Zn/c1-3-2-6-4(8)10-12-11-5(9)7-3/h3H,2H2,1H3,(H,6,8)(H,7,9)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Carbamate
Minimum active substance purity -
Known relevant impurities EU dossier: aresenic as an impurity
Substance origin Synthetic
Mode of action Contact action with protective properties and long residual activity. Multi-site activity.
CAS RN 12071-83-9
Alternative/old CAS RN 9016-72-2
EC number 235-134-0
CIPAC number 177
US EPA chemical code 522200
PubChem CID 6100711
Molecular mass (g mol-1) 289.80
PIN (Preferred Identification Name) -
IUPAC name polymeric zinc propylenebis(dithiocarbamate)
CAS name ((2-((dithiocarboxy)amino)-1-methylethyl)carbamodithioato))(2-)-kS,kS')zinc
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) M3
Examples of recorded resistance -
Physical state White powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
  • AgroSan
  • FCC
  • Farmoplant
Example products using this active
  • Melody Duo
  • Antracol
  • Aerial
  • Agrocol
UK LERAP status None
Formulation and application details Available in a variety of formulations including dusts, flowables, water-dispersible granules and wettable powders.


ENVIRONMENTAL FATE

for propineb

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 10 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 100 A5 - Toluene -
100 A5 - Acetone -
100 A5 - n-Heptane -
100 A5 - Dichloromethane -
Melting point (oC) Decomposes before melting A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 150 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 5.50 X 10-01 Calculated -
Log P -0.26 A5 Low
Bulk density (g ml-1)/Specific gravity 1.81 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: Not determinable
Vapour pressure at 20oC (mPa) 0.16 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 8.00 X 10-08 A3 - for main metablite PTU Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index - - -
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value - - -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - - -
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 4.3 A5 Non-persistent
DT50 (lab at 20oC) 4.3 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 0.4 A4 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU 2015 dossier lab studies DT50 range 0.5-8.1 days, Soils=2; EU 2003 dossier Lab studies DT50 range 0.1-6 days, DT90 range 0.12-19 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 3.0 R4 -
Note Published literature RL50 range 2.3-5.3 days, 6 field crops, various matrices, n=9
Aqueous photolysis DT50 (days) at pH 7 Value 0.1 A5 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 1.5 A4 Non-persistent
Note pH sensitive: DT50 24 hours at pH 4, 53 hours at pH 9 all at 22 degC
Water-sediment DT50 (days) 30 A5 Moderately fast
Water phase only DT50 (days) 1.0 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
propylene urea This metabolite may cause environmental pollution, click here for further information Soil   0.422   Major fraction, Relevant
propylene thiourea This metabolite may cause environmental pollution, click here for further information Soil   0.313   Major fraction, Relevant
propineb-DIDT This metabolite may cause environmental pollution, click here for further information Soil   0.256   Major fraction, Relevant
4-methyl-imidazoline hydrochloride This metabolite may cause environmental pollution, click here for further information Soil   0.117   Major fraction, Relevant


ECOTOXICOLOGY

for propineb

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - A5 Rat -
(ppm diet) 800 -
Birds - Acute LD50 (mg kg-1) > 5000 A5 Coturnix japonica Low
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A4 Unknown species -
Fish - Acute 96 hour LC50 (mg l-1) 0.33 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.082 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 1.5 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.015 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.055 A4 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 107.9 A5 Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 700 A5 Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 5.6 Mortality
A5 Typhlodromus pyri
-
% Effect 0 Mortality
Dose: 1.3 kg ha-1
A5 Poecilus cupreus, adult
-
Other arthropod (2) LR50 g ha-1 7000 A5 Aphidius rhopalosiphi -
% Effect 0 Beneficial capacity - Full recovery after 4 weeks
Dose: Field rate
A3 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 100.8 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for propineb

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 2.42 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.007 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.003 A4 Rat, 1 year, SF=100 -
Dermal penetration studies (%) 0.007 A5 -
Dangerous Substances Directive 76/464 List II - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E0

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Primarily distributes via the thyroid gland, potentially thyroid toxicant
May damage lungs or cause muscular problems
USEPA - probable human carcinogen, EFSA - no carcinogenic potential
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Avoid generation of dust
IMDG Transport Code is usually 9
Not oxidising or explosive
CLP classification 2013 Health: H317, H332, H373
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R20, R48/22, R43
N - Dangerous for the environment: R50
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for propineb

Language Name
English propineb
French propinebe
German Propineb
Danish propineb
Italian propineb
Spanish propineb
Greek -
Slovenian propineb
Polish propineb
Swedish -
Hungarian propineb
Dutch -

Record last updated: Tuesday 29 October 2019
Contact: aeru@herts.ac.uk