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GET ADDITIONAL DATA HERE!

propyzamide (Ref: RH 315)
** pronamide ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for propyzamide

Description: A residual, systemic post-emergent herbicide for use in a wide range of crops to control annual and perennial weeds

Example pests controlled: Certain grasses; broad-leaved weeds including chickweed, mayweed, poppy, black bindweed, fat hen, speedwells

Example applications: Alfalfa; OSR; Beans; Root crops; Fruit including apples, blackberry, boysenberry, blueberry, cherry, peach, pear, plum, prunes, grapes and others; Artichoke; Clover; Endive and various head lettuce; Ornamentals; Non-cropped and utility sites

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1969

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Sweden/UK
Date inclusion expires 30/06/2025
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None
Chemical formula C12H11Cl2NO
Canonical SMILES CC(C)(C#C)NC(=O)C1=CC(=CC(=C1)Cl)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) PHNUZKMIPFFYSO-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H11Cl2NO/c1-4-12(2,3)15-11(16)8-5-9(13)7-10(14)6-8/h1,5-7H,2-3H3,(H,15,16)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Benzamide
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Selective, systemic absorbed by roots and translocated. Microtubule assembly inhibition.
CAS RN 23950-58-5
EC number 245-951-4
CIPAC number 315
US EPA chemical code 101701
PubChem CID 32154
Molecular mass (g mol-1) 256.13
PIN (Preferred Identification Name) -
IUPAC name 3,5-dichloro-N-(1,1-dimethylprop-2-ynyl)benzamide
CAS name 3,5-dichloro-N-(1,1-dimethyl-2-propynyl)benzamide
Other status information Potential groundwater contaminant
Relevant Environmental Water Quality Standards UK Environment Agency non-statutory standard for the protection of aquatic life in freshwater and saltwater: 100 ug/L as annual average; 1000 ug/L as max acceptable conc.]
Herbicide Resistance Classification (HRAC) K1
Herbicide Resistance Classification (WSSA) 3
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Off-white powdery solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Dow AgroSciences
  • Interfarm Ltd
  • Standon
  • SumiAgro
  • Rohm & Haas
Example products using this active
  • Bulwark Flo
  • Kerb 50W
  • Kerb Flo
  • Kerb ProFlo
  • Menace
  • Clanex
  • ASTROkerb
UK LERAP status None
Formulation and application details Available in a variety of formulations including granules & wettable powders.


ENVIRONMENTAL FATE

for propyzamide

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 9.0 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 139000 A5 - Acetone -
63800 A5 - Methanol -
501 A5 - Hexane -
9670 A5 - Toluene -
Melting point (oC) 156 A5 -
Boiling point (oC) 283 A5 -
Degradation point (oC) 281 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.86 X 1003 Calculated -
Log P 3.27 A5 High
Bulk density (g ml-1)/Specific gravity 1.33 A5 -
Dissociation constant (pKa) at 25oC 10.38 A5 -
Note:
Vapour pressure at 20oC (mPa) 0.058 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 7.52 X 10-09 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.34 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.21 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 pH7: 207nm=42200
pH 12.4: 206nm=43600
pH 0.6: 219nm=14300
A5 -
Surface tension (mN m-1) 71.5 A5 at 20 degC, 90% -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 50.5 A5 Moderately persistent
DT50 (lab at 20oC) 50.5 A5 Moderately persistent
DT50 (field) 233 A5 Persistent
DT90 (lab at 20oC) 65 A5 -
DT90 (field) 185 A5 -
DT50 modelling endpoint - - -
Note EU 2016 dossier lab studies DT50 range 13.9-271.3 days, DT90 range 59.2-648.3 days, Soils=8
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 63.8 R3 -
Note Alfalfa leaves, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 41 A5 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Very slow, almost stable pH 4 to pH 9
Water-sediment DT50 (days) 94 A5 Moderately fast
Water phase only DT50 (days) 21 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 5.5 A5 Slightly mobile
Koc 840
Notes and range EU 2003 dossier Kd range 3.2-10.0 mL/g, Koc range 548-1340 mL/g, Soils=6
Freundlich Kf 19.9 A5 Slightly mobile
Kfoc 1626
1/n 1.02
Notes and range EU 2016 dossier Kf range 18-47 mL/g, Kfoc range 703-5390 mL/g, 1/n range 0.96-1.08, Soils=8
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-(3,5-dichlorophenyl)-4,4-dimethyl-5-methylene-oxazoline (Ref: RH-24644) This metabolite may cause environmental pollution, click here for further information Soil   0.415   Major fraction, Not relevant
N-(1,1-dimethylacetonyl)-3,5-dichlorobenzamide (Ref: RH-24580) This metabolite may cause environmental pollution, click here for further information Soil   0.240   Major fraction, Not relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
3,5-dichlorobenzoic acid
(Ref: RH-20839)
- Water (Photolysis); Soil (Aerobic) - -
3,5-dichlorobenzamide
(Ref: RH-24298)
- Water (Photolysis) - -
3,5-dichloro-N-(1,1-dimethyl-2-propenyl)benzamide
(Ref: RH-24655)
- Water - -
2-(3,5-dichlorophenyl)-4,4-dimethyl-S-hydroxymethyloxazoline
(Ref: RH-25891)
- Soil (Anaerobic); Water (Photolysis) - -
beta-(3,5-dichlorobenzamido)-beta-mebutyric acid
(Ref: RH-26059)
- Water (Photolysis) - -
N-(1,1-dimethyl-2,3-dihydroxypropyl)-3,5-dichlorobenzamide
(Ref: RH-26521)
- Soil (Aerobic); Water - -
N-(1,1-dimethyl-3-hydroxacetonyl)-3,5-dichlorobenzamide
(Ref: RH-26702)
- Soil (Photolysis); Water (Photolysis) - -


ECOTOXICOLOGY

for propyzamide

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 49 A5 Low potential
CT50 (days) 42 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - A5 Rat -
(ppm diet) > 200 -
Birds - Acute LD50 (mg kg-1) 6578 A5 Coturnix japonica Low
Birds - Short term dietary (LC50/LD50) > 10000 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 4.7 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.94 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 5.6 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.6 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 3.9 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 1.4 A5 Lemna spp. Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 2.8 A5 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 136 A5 Low
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 173 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 34.0 A5 Eisenia foetida, 56 days Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 0
4
Mortality
Beneficial capacity
Dose: 2.5 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 80
99
Mortality
Offspring
Dose: 5.0 kg ha-1
A5 Typhlodromus pyri, lifecycle
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A3
Dose: Not stated
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for propyzamide

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 2.1 A5 Rat, 4 hr (nose only, aerosol) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.02 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) None allocated A5 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.08 A3 Rabbit, SF=100 -
Dermal penetration studies (%) 17-19 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Possible liver, kidney & spleen toxicant
Associated with thyroid follicular cell adenomas and Leydig cell benign tumours

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H351
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 2: R41
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S60, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number Variable with product, usually 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for propyzamide

Language Name
English propyzamide
French propyzamide
German Propyzamid
Danish propyzamide
Italian propizamide
Spanish propizamida; pronamida
Greek propyzamide
Slovenian propizamid
Polish propyzamid
Swedish propyzamid
Hungarian propizamid
Dutch -

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk