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GET ADDITIONAL DATA HERE!

silthiofam (Ref: MON 65500)
** silthiopham ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for silthiofam

Description: A new protectant fungicide seed dressing for cereals used mainly to control 'take-all'

Example pests controlled: Take-all

Example applications: Cereals including winter wheat, barley, triticale

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1999

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Ireland/Belgium
Date inclusion expires 30/06/2033
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C13H21NOSSi
Canonical SMILES CC1=C(SC(=C1C(=O)NCC=C)[Si](C)(C)C)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) MXMXHPPIGKYTAR-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C13H21NOSSi/c1-7-8-14-12(15)11-9(2)10(3)16-13(11)17(4,5)6/h7H,1,8H2,2-6H3,(H,14,15)/f/h14H
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Thiophene
Minimum active substance purity 980 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Protective action with long-lasting activity. Respiration inhibitor - ATR production.
CAS RN 175217-20-6
EC number -
CIPAC number 635
US EPA chemical code -
PubChem CID 16116
Molecular mass (g mol-1) 267.47
PIN (Preferred Identification Name) 4,5-dimethyl-N-(prop-2-en-1-yl)-2-(trimethylsilyl)thiophene-3-carboxamide
IUPAC name N-allyl-4,5-dimethyl-2-(trimethylsilyl)thiophene-3-carboxamide
CAS name 4,5-dimethyl-N-2-propenyl-2-(trimethylsilyl)-3-thiophenecarboxamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 38
Examples of recorded resistance -
Physical state White powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Monsanto
Example products using this active
  • Latitude
UK LERAP status None (may vary with mixtures)
Formulation and application details Often supplied as a flowable concentrate for use as a seed treatment.


ENVIRONMENTAL FATE

for silthiofam

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.04 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 15500 A5 - n-Heptane -
250000 A5 - p-Xylene -
250000 A5 - Methanol -
250000 A5 - Ethyl acetate -
Melting point (oC) 88 A5 -
Boiling point (oC) 322 A5 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 5.25 X 1003 Calculated -
Log P 3.72 A5 High
Bulk density (g ml-1)/Specific gravity 1.07 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 81.0 A5 Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1) 5.40 X 10-01 A5 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.60 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.72 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral soln: 245nm=8277
Acid soln: 245nm=8395
Basic soln: 245nm=8530
A5 -
Surface tension (mN m-1) 60.4 A5 at 20 degC, 99.7% -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 42.3 A5 Moderately persistent
DT50 (lab at 20oC) 42.3 A5 Moderately persistent
DT50 (field) 66 A5 Moderately persistent
DT90 (lab at 20oC) 137.5 A5 -
DT90 (field) 241 A5 -
DT50 modelling endpoint - - -
Note EU 2016 dossier lab studies DT50 range 26.5-60.8 days, Soils=9; EU 2003 dossier lab studies DT50 range 25-34 days, DT90 range 110-164 days, field study DT50 range 8-116 days (EU), DT90 range 86-387 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 16 A5 Slow
Note Data for irradiated sterile water at 25 degC
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note pH and temp sensitive: DT50 73hrs pH4, 20 degC; 45hrs pH4, 25 degC; 5.2hrs pH4, 50 degC; 61days pH5, 25 degC; 448days pH7, 25 degC; 118days pH7, 50 degC; 77yrs pH9, 20 degC; 314days pH9, 25 degC; 196days pH9, 38 degC; 99days pH9, 50 degC
Water-sediment DT50 (days) 269 A5 Slow
Water phase only DT50 (days) 5 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 3.7 A5 Moderately mobile
Kfoc 250.3
1/n 0.90
Notes and range EU dossier Kf=0.98-6.41 mL/g, Kfoc range 173-328 mL/g, 1/n range 0.81-0.95, Soils=4
pH sensitivity Adsorption decreases as pH increases

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
N-allyl-4,5-dimethylthiophene-3-carboxamide (Ref: CP-240659) This metabolite may cause environmental pollution, click here for further information Soil   0.229   Major fraction, Relevant
4,5-dimethyl-2-(trimethylsilyl)thiophene-3-carboxamide (Ref: MON 65561) This metabolite may cause environmental pollution, click here for further information Soil   0.102   Major fraction, Relevant
4-(allylcarbamoyl)-3-methyl-5-(trimethylsilyl)thiophene-2-carboxylic acid (Ref: MON 65533) This metabolite may cause environmental pollution, click here for further information Soil   0.123   Major fraction, Relevant
4-carbamoyl-3-methyl-5-(trimethylsilyl)thiophene-2-carboxylic acid (Ref: MON 65534) This metabolite may cause environmental pollution, click here for further information Soil   0.133   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: MON 65513)
Note: LC50(fish) = 71 mg l-1
- - - -


ECOTOXICOLOGY

for silthiofam

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 98 A5 Whole fish Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - A5 Rat -
(ppm diet) > 1000 -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5670 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 11 A5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 14 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.47 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 8.6 A4 Rhapidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 105.7 A5 Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 133 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 0.27 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 0 Mortality
Fecundity
Dose: 0.04 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect -41.8 Mortality and Fecundity
Dose: 0.04 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.08 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for silthiofam

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 2.8 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.064 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.1 A4 Dog, 90 day, SF=100 -
Dermal penetration studies (%) 10 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

A3; B0; C0; D0; E3

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Possible liver toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 None allocated at this time
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R43
N - Dangerous for the environment: R52, R53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for silthiofam

Language Name
English silthiofam
French silthiopham
German Silthiofam
Danish silthiofam
Italian siltiofam
Spanish siltiofam
Greek -
Slovenian siltiofam
Polish siltiofam
Swedish siltiofam
Hungarian -
Dutch -

Record last updated: Tuesday 02 July 2019
Contact: aeru@herts.ac.uk