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GET ADDITIONAL DATA HERE!

spinosad (Ref: XDE 105)
** DE 105 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
Further data may be found in the BPDB

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for spinosad

Description: An insecticide derived from naturally occurring soil fungi (naturalyte) used to control Lepidoptera

Example pests controlled: Thrips; Gypsy moth; Leaf beetles; Tent caterpillars

Example applications: Onions & Leeks; Corn; Sweetcorn; Maize; Lettuce; Leafy vegetables; Potato; Eggplants; Pepper; Tomato; Celery; Fruit including grapes, cane fruits, berries, currants; Herbs & edible flowers

Efficacy & activity: -

Availability status: Current, mix of synosyn A & spinosyn D

Introduction & key dates: 1982, first identified; 1997, commercially introduced

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Netherlands/France
Date inclusion expires 30/04/2020
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule. The technical material is a mixture of spinosyn A and D.
Chemical formula C41H65NO10 (spinosyn A) + C42H67NO10 (spinosyn D)
Canonical SMILES CCC1CCCC(C(C(=O)C2=CC3C4CC(CC4C=CC3C2CC(=O)O1)OC5C(C(C(C(O5)C)OC)OC)OC)C)OC6CCC(C(O6)C)N(C)C.CCC1CCCC(C(C(=O)C2=CC3C4CC(CC4C(=CC3C2CC(=O)O1)C)OC5C(C(C(C(O5)C)OC)OC)OC)C)OC6CCC(C(O6)C)N(C)C
Isomeric SMILES CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3[C@@H]2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C
International Chemical Identifier key (InChIKey) JFLRKDZMHNBDQS-SGSTVUCESA-N
International Chemical Identifier (InChI) InChI=1S/C42H71NO9/c1-10-27-12-11-13-35(52-38-17-16-34(43(5)6)25(4)49-38)24(3)39(45)33-21-31-29(32(33)22-37(44)51-27)15-14-26-19-28(20-30(26)31)50-36-18-23(2)40(46-7)42(48-9)41(36)47-8/h23-36,38,40-42H,10-22H2,1-9H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Micro-organism derived
Minimum active substance purity 850 g/kg, 50-95% spinosyn A & 5-50% spinosyn D
Known relevant impurities EU dossier - None declared
Substance origin Natural
Mode of action Contact and stomach action. Acts by exciting the insect nervous system, leading to involuntary muscle contractions and paralysis.
CAS RN 168316-95-8
EC number 434-300-1
CIPAC number 636
US EPA chemical code 110003
PubChem CID -
Molecular mass (g mol-1) 731.98+745.98
PIN (Preferred Identification Name) -
IUPAC name mix of 50-95% (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-(6-deoxy-2,3,4-tri-O-methyl-αL-mannopyranosyloxy)-13-(4-dimethylamino-2,3,4,6-tetradeoxy-β-D-erythropyranosyloxy)-9-ethyl-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione and 50-5% (2S,3aR,5aS,5bS,9S,13S,14R,16aS,16bS)-2-(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyloxy)-13-(4-dimethylamino-2,3,4,6-tetradeoxy-β-D-erythropyranosyloxy)-9-ethyl-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-4,14-dimethyl-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione
CAS name 2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-((6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy)-13-(((2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecin-7,15-dione mixture with (2S,3aR,5aS,5bS,9S,13S,14R,16aS,16bS)-2-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl)oxy)-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dimethyl-1H-as-indaceno(3,2-d)oxacyclododecin-7,15-dione
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 5
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Deraeocoris brevis
Frankliniella occidentalis
Liriomyza trifolii
Plutella xylostella
Spodoptera exigua
Physical state Technical substance is a white-grey crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically -
Example products using this active -
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as a soluble concentrate that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for spinosad

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 7.6 A4 Low
Solubility - In organic solvents at 20oC (mg l-1) 168000 P4 - Acetone -
36900 P4 - Ethyl acetate -
4480 P4 - Hexane -
190000 P4 - Methanol -
Melting point (oC) 136 A4 -
Boiling point (oC) 225 A4 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.26 X 1004 Calculated -
Log P 4.1 A4 High
Bulk density (g ml-1)/Specific gravity 0.51 L3 -
Dissociation constant (pKa) at 25oC 8.0 A3 - -
Note: Mean of protonated spinosyn A & D
Vapour pressure at 20oC (mPa) 1.00 X 10-05 A4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.89 X 10-07 C4 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.63 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) 41.5 A3 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 14 L3 Non-persistent
DT50 (lab at 20oC) 15 P4 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) 3.3 A3 -
DT50 modelling endpoint - - -
Note More accurate data can be found under the separate synosad components - spinosyn A and spinosyn D
Dissipation rate RL50 on plant matrix Value 49 R3 -
Note Published literature RL50 range 1.4-138 days, 3 field & undercover grown crops, various matrices, n=3
Dissipation rate RL50 on and in plant matrix Value 2.5 R4 -
Note Published literature RL50 range 1.2-4.0 days, 8 field grown crops, various matrices, n=10
Aqueous photolysis DT50 (days) at pH 7 Value 0.9 A5 Fast
Note Spinosyn A: DT50 0.96 days at pH 7 and 25 degC distilled water, 0.18 days at pH 9.2 and 25 degC pond water; Spinosyn D: DT50 0.84 days at pH 7 and 25 degC distilled water, 0.18 days at pH 9.2 and 25 degC pond wate
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 and pH 7, DT50 200 days for spinosyn A and 259 days for spinosyn D at pH 9, all at 25 degC
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - P4 Non-mobile
Koc 34600
Notes and range Other sources: Spinosad A 16400 mL/g, Spinosad D 20000 mL/g (DW4). More accurate data can be found under the separate synosad components - spinosyn A and spinosyn D
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
spinosyn B This metabolite may cause environmental pollution, click here for further information Soil   0.670   Major fraction, Relevancy unknown
N-demethylated spinosyn D This metabolite may cause environmental pollution, click here for further information Soil   0.680   Major fraction, Relevancy unknown


ECOTOXICOLOGY

for spinosad

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 0.1 F4 Whole fish Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 9 L3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A4 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 5156 mg kg feed-1 A3 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 27 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 1.22 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 1.0 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0012 A3 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.0016 A3 Chironomus riparius High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 10.6 C4 Lemna minor Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 6.1 A3 Anabaena flos-aquae Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.0036 A5 Apis mellifera High
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.057 A5 Apis mellifera High
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 0.37 A5 Bombus terrestris High
Literature LD50 values range 0.37-17.2 ug/bee
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.385 R4 Bombus terrestris High
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 2.59 R4 Osmia bicornis Moderate
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) 1.25 R4 Megachile rotundata Moderate
Mode of exposure Contact
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) 0.012 R4 Melipona quadrifasciata High
Mode of exposure Oral
Earthworms - Acute 14 day LC50 (mg kg-1) > 458 A3 Eisenia foetida, corr Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) 1.79 A3 Eisenia foetida, corr Moderate
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 0.37 A3 Aphidius rhopalosiphi -
% Effect 100 Mortality
Dose: 0.32 kg ha-1
A5 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 8.54 A5 Typhlodromus pyri -
% Effect 100 Mortality
Dose: 0.031 kg ha-1
A3 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A3
Dose: 7.2 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for spinosad

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class - - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rabbit -
Mammals - Inhalation LC50 (mg l-1) > 5.18 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.024 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.013 A5 -
Dermal penetration studies (%) 0.1-10.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
May be absorbed into the body by ingestion
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Possible thyroid toxicant
May cause inflammation of various organs
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of dust
Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xi - Irritant: R36/38
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification III - Slightly hazardous
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for spinosad

Language Name
English spinosad
French spinosad
German Spinosad
Danish spinosad
Italian spinosad
Spanish spinosad
Greek -
Slovenian spinosad
Polish spinosad
Swedish spinosad
Hungarian -
Dutch spinosad

Record last updated: Monday 28 October 2019
Contact: aeru@herts.ac.uk