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sulfosulfuron (Ref: MON 37500)
** TKM 19 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

A sulfonylurea herbicide approved for use in the European Union and in some other countries. Sulfosulfuron is highly soluble in water, is semi-volatile and is mobile with a high potential for leaching to groundwater based on its physico-chemical properties. It is considered to be moderately persistent in soils and can also be persistent in water systems depending upon conditions. It may bioaccumulate but has a low mammalian toxicity. It is moderately toxic to fish, algae, earthworms and honeybees but less so to birds and aquatic invertebrates.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for sulfosulfuron

Description: A herbicide for annual grass and broad-leaved weed control in cereals and other crops

Example pests controlled: Bermudagrass; Buffalograss; Nutsedge; Bromegrass; Mayweed; Wild mustard; Bedstraw; Dandylion; Henbit; Quackgrass; Shepherds purse; Chickweed

Example applications: Cereals including wheat, triticale; Turf

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1999, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Sweden/Ireland
Date inclusion expires 31/12/2030
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C16H18N6O7S2
Canonical SMILES CCS(=O)(=O)C1=C(N2C=CC=CC2=N1)S(=O)(=O)NC(=O)NC3=NC(=CC(=N3)OC)OC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) RBSXHDIPCIWOMG-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C16H18N6O7S2/c1-4-30(24,25)13-14(22-8-6-5-7-10(22)17-13)31(26,27)21-16(23)20-15-18-11(28-2)9-12(19-15)29-3/h5-9H,4H2,1-3H3,(H2,18,19,20,21,23)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Sulfonylurea
Minimum active substance purity 980 g/kg
Known relevant impurities EU dossier - Phenol < 2g/kg
Substance origin Synthetic
Mode of action Systemic, absorbed by roots and leaves and translocated. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS
CAS RN 141776-32-1
EC number -
CIPAC number 601
US EPA chemical code 085601
PubChem CID 86426
Molecular mass (g mol-1) 470.48
PIN (Preferred Identification Name) N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-(ethanesulfonyl)imidazo[1,2-a]pyridine-3-sulfonamide
IUPAC name 1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethylsulfonylimidazo[1,2-a]pyridin-3-ylsulfonyl)urea
CAS name N-(((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)-2-(ethylsulfonyl)imidazo(1,2-a)pyridine-3-sulfonamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) B
Herbicide Resistance Classification (WSSA) 2
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Avena fatua
Phalaris minor
Hordeum glaucum
Physical state White solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • DuPont
  • Monsanto
Example products using this active
  • SafeGuard
  • Certainty
  • Maverick
  • Outrider
  • Arrow
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as wettable granules that are mixed with water and used as a spray.


ENVIRONMENTAL FATE

for sulfosulfuron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 1627 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 1 A5 - Heptane -
160 A5 - Xylene -
330 A5 - Methanol -
710 A5 - Acetone -
Melting point (oC) 201.5 A5 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.70 X 10-01 Calculated -
Log P -0.77 A5 Low
Bulk density (g ml-1)/Specific gravity 1.52 A5 -
Dissociation constant (pKa) at 25oC 3.51 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 3.05 X 10-05 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 8.83 X 10-09 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 4.48 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.10 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 pH 10: 208nm=187150
pH 7: 208nm=38019
A5 -
Surface tension (mN m-1) 72.7 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 63.8 A5 Moderately persistent
DT50 (lab at 20oC) 63.8 A5 Moderately persistent
DT50 (field) 44.5 A5 Moderately persistent
DT90 (lab at 20oC) 309 A5 -
DT90 (field) 148 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 12.0-224.4 days, DT90 range 55.4-731 days, field studies DT50 range 28.8-75.1 days, DT90 range 81.9-250 days; Other sources: 50 days (DW4)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 3.1 R3 -
Note Wheat straw, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 1.4 A5 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 164 A5 Persistent
Note pH sensitive: DT50 7 days at pH 4, 48 days at pH 5, 147 days at pH 9, all at 25 degC
Water-sediment DT50 (days) 26.8 A5 Fast
Water phase only DT50 (days) 17.8 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 0.29 A5 Mobile
Kfoc 33.0
1/n 0.930
Notes and range EU dossier Kf range 0.076-0.710 mL/g, Koc range 5.3 89.0 mL/g, 1/n range 0.737-1.20, Soils=5
pH sensitivity Adsorption increases with decreasing soil pH

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
sulfosulfuron sulfonamide (Ref: MON 52729) This metabolite may cause environmental pollution, click here for further information Soil   0.547   Major fraction, Relevant
desmethyl sulfosulfuron (Ref: MON 52756) This metabolite may cause environmental pollution, click here for further information Soil   0.335   Major fraction, Relevant
sulfosulfuron aminopyrimidine (Ref: CP 017477) This metabolite may cause environmental pollution, click here for further information Soil   0.399   Minor fraction, Relevant
sulfosulfuron guanidine (Ref: MON 52726) This metabolite may cause environmental pollution, click here for further information Soil   0.188   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
1-(4,6-dimethoxy-2-pyrimidinyl)-3-hydroxyurea
(Ref: -)
sulfosulfuron N-hydroxy urea Groundwater; Surface water (Photolysis) - -
2-(ethylsulfonyl)imidazo[1,2-alpha]pyridine-3-sulfonic acid
(Ref: CP 180421)
sulfosulfuron sulfonic acid Surface water(Photolysis); Groundwater - -
2-(ethylsulfonyl)imidazo[1,2-alpha]pyridine
(Ref: CP 180425)
sulfosulfuron sulfone Surface water; Groundwater - -
1-(4,6-dimethoxy-2-pyrimidinyl)urea
(Ref: CP 240483)
sulfosulfuron urea Surface water; Groundwater - -
(2-imino-1(2H)-pyridinyl)(oxo)acetic acid
(Ref: CP 240488)
sulfosulfuron oxamic acid Surface water; Groundwater - -
N-carbamoyl-2-(ethylsulfonyl)imidazo[1,2-a]pyridine-3-sulfonamide
(Ref: MON 37500)
sulfosulfuron sulfonylurea Groundwater; Soil - -
N-(carbamoylcarbamoyl)-2-(ethylsulfonyl)imidazo[1,2-alpha]pyridine-3-sulfonamide
(Ref: MON 52727)
sulfonyl biuret Groundwater; Soil - -
[(4,6-dimethoxy-2-pyrimidinyl)carbamoyl]sulfamic acid
(Ref: MON 52728)
sulfosulfuron sulfamic acid Surface water; Water (Photolysis) - -


ECOTOXICOLOGY

for sulfosulfuron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 370 A5 Rat Moderate
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 5310 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) > 91 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 100 A5 Oncorhynchus mykiss Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 96 A4 Unknown species Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 102 A5 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 106.0 F3 Americamysis bahia Low
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.00096 F3 Lemna gibba High
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.221 A3 Unknown species, 72 hour Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 25 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 30 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 848 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) >= 0.13 A4 Eisenia foetida, 56 day Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 7 Fecundity
Dose: 0.03 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 30 Mortality
Dose: 0.03 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 5.76 x field rate, 100 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for sulfosulfuron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 3.0 A5 Rat, 4hr (head-nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.24 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.4 A4 Dog 90 day, SF=250 -
Dermal penetration studies (%) 25-75 A5 concentration dependent, default -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues May caused weight loss, renal and bladder problems
Possible kidney, bladder, urinary system toxicant
USEPA - possible human carcinogen at high doses

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Risk of explosion - prevent generation of dusts
Not oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification NL - Not listed
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for sulfosulfuron

Language Name
English sulfosulfuron
French sulfosulfuron
German Sulfosulfuron
Danish sulfosulfuron
Italian sulfosulfuron
Spanish sulfosulfuron
Greek sulfosulfuron
Slovenian sulfosulfuron
Polish sulfosulfuron
Swedish sulfosulfuron
Hungarian szulfoszulfuron
Dutch sulfosulfuron

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk