| tebuthiuron (Ref: EL 103) |
 |
Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for tebuthiuron
Description: A herbicide used to control a broad range of herbaceous, woody, annual and perennial weeds in non-cropland areas, rights-of-way, and industrial sites
Example pests controlled: Bluegrass; Chickweed; Clover; Docks; Virginia creeper; Whitethorn; Eastern cottonwood; Chamise; Blackberry; Black higory; Bitternut hickory
Example applications: Non-crop areas such as paths; roads, right-of-way, industrial sites
Efficacy & activity: -
Availability status: Current
Introduction & key dates: 1975, Brazil
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | Not applicable |
| Date inclusion expires | Expired |
| EU Candidate for substitution (CfS) | - |
| Listed in EU database | Yes |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Also used in: Australia, USA
Chemical structure:
| Isomerism | - |
| Chemical formula | C9H16N4OS |
| Canonical SMILES | CC(C)(C)C1=NN=C(S1)N(C)C(=O)NC |
| Isomeric SMILES | No data |
| International Chemical Identifier key (InChIKey) | HBPDKDSFLXWOAE-UHFFFAOYSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C9H16N4OS/c1-9(2,3)6-11-12-8(15-6)13(5)7(14)10-4/h1-5H3,(H,10,14) |
| 2D structure diagram/image available? | Yes |
General status:
| Pesticide type | Herbicide | |||
| Substance group | Urea | |||
| Minimum active substance purity | - | |||
| Known relevant impurities | - | |||
| Substance origin | Synthetic | |||
| Mode of action | Systemic, low selectivity, absorbed by roots and translocated. Inhibits photosynthesis (photosystem II). | |||
| CAS RN | 34014-18-1 | |||
| EC number | 251-793-7 | |||
| CIPAC number | 8321 | |||
| US EPA chemical code | 105501 | |||
| PubChem CID | 5383 | |||
| Molecular mass (g mol-1) | 228.31 | |||
| PIN (Preferred Identification Name) | N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-N,N'-dimethylurea | |||
| IUPAC name | 1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-1,3-dimethylurea | |||
| CAS name | N-[5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]-N,N'-dimethylurea | |||
| Other status information | Potential groundwater contaminant | |||
| Relevant Environmental Water Quality Standards | - | |||
| Herbicide Resistance Classification (HRAC) | C2 | |||
| Herbicide Resistance Classification (WSSA) | 7 | |||
| Insecticide Resistance Classification (IRAC) | Not applicable | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Examples of recorded resistance | - | |||
| Physical state | Off-white to buff coloured crystalline solid | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
|
|||
| Example products using this active |
|
|||
| UK LERAP status | No UK approval for use as a pesticide under EC Regulation 1107/2009 | |||
| Formulation and application details | Usually supplied as wettable powders, granules or pellets. | |||
ENVIRONMENTAL FATE
for tebuthiuron
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 2500 | G4 | High | |
| Solubility - In organic solvents at 20oC (mg l-1) | 3700 | L3 - Benzene | - | |
| 6100 | L3 - Hexane | - | ||
| 70000 | L3 - Acetone | - | ||
| 170000 | L3 - Methanol | - | ||
| Melting point (oC) | 162.9 | L3 | - | |
| Boiling point (oC) | Decomposes before boiling | L3 | - | |
| Degradation point (oC) | 275 | L3 | - | |
| Flashpoint (oC) | - | - | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 6.17 X 1001 | Calculated | - |
| Log P | 1.79 | G4 | Low | |
| Bulk density (g ml-1)/Specific gravity | 1.19 | Q2 | - | |
| Dissociation constant (pKa) at 25oC | - | - | - | |
| Note: | ||||
| Vapour pressure at 20oC (mPa) | 0.27 | G4 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 2.47 X 10-05 | L3 | Non-volatile | |
GUS leaching potential index  |
5.36 | Calculated | High leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 8.52 X 10+00 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Medium | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 400 | G4 | Very persistent |
| DT50 (lab at 20oC) | 360 | F3 | Persistent | |
| DT50 (field) | - | - | - | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | General literature data. Other sources: 1300 days at 25 DegC (R3) | |||
| Dissipation rate RL50 on plant matrix | Value | - | - | - |
| Note | - | |||
| Dissipation rate RL50 on and in plant matrix | Value | - | - | - |
| Note | - | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | - | - | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 64 | L3 | Moderately persistent |
| Note | Not sensitive to pH | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | F4 | Moderately mobile |
| Koc | 80 | |||
| Notes and range | Other data: Log Koc 2.1 @ 25 DegC (R3) | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
Other known metabolites:
| Metabolite name and reference | Aliases | Formation medium / Rate | Estimated maximum occurrence fraction | Metabolising enzymes |
| N-(5-[1,1-dimethylethyl]-1,3,4-thiadazol-2-yl)-N'-(hydroxymethyl)-N-methyl urea | - | - | - | - |
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 2.6 | F4 Whole fish | Low potential |
| CT50 (days) | Not available | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 644 | G4 Rat | Moderate | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | L3 Rat | - |
| (ppm diet) | 800 | - | ||
| Birds - Acute LD50 (mg kg-1) | > 2500 | G4 Anas platyrhynchos | Low | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | > 87 | G4 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | > 225 | G4 Daphnia magna | Low | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | > 0.135 | F3 Lemna gibba | Moderate | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | 0.05 | L3 Raphidocelis subcapitata | Moderate | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | > 30 | G4 | Moderate |
| Oral acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | > 690 | E3 in silicon media | Moderate | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for tebuthiuron
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 644 | G4 Rat | Moderate | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | > 5000 | L3 Rabbit | - | |
| Mammals - Inhalation LC50 (mg l-1) | 3.7 | L3 Rat | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.07 | L3 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | - | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | - | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
|
|
- |
|
|
- |
|||
| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
- |
|
- |
|
- |
|
|||
| General human health issues | Moderately toxic Blood, liver, pancreas and kidney toxicant |
|||||||
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
No information available | |||
| CLP classification 2013 | Health: H302 Environment: H400, H410 |
|||
| EC Risk Classification |
Xn - Harmful: R22 N - Dangerous for the environment: R50, R53 |
|||
| EC Safety Classification |
S2, S37, S60, S61 | |||
| WHO Classification | II | - | Moderately hazardous | |
| US EPA Classification (formulation) | III | - | Caution - Slightly toxic | |
| UN Number | - | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | tebuthiuron |
| French | tebuthiuron |
| German | Tebuthiuron |
| Danish | tebuthiuron |
| Italian | tebutiuron |
| Spanish | tebutiuron |
| Greek | - |
| Slovenian | tebutiuron |
| Polish | tebutiuron |
| Swedish | - |
| Hungarian | - |
| Dutch | - |
Record last updated: Friday 25 May 2018
Contact: aeru@herts.ac.uk