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GET ADDITIONAL DATA HERE!
teflubenzuron (Ref: CME 13406)
** tefluron ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
Further data may be found in the VSDB

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for teflubenzuron

Description: An insecticide used to control a range of pests mainly on greenhouse crops and tree fruit. Also used to control sea lice in fisheries.

Example pests controlled: Whiteflies; Caterpillars; Codling moth; Leafminers; Thrips; Pear psylla; Beetles

Example applications: Apples; Pears; Greenhouse crops including tomatoes, aubergine, cucumber, melon, pepper

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1983, first reported; 1984, introduced Thailand

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Sweden/Italy
Date inclusion expires -
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C14H6Cl2F4N2O2
Canonical SMILES C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC(=C(C(=C2F)Cl)F)Cl)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) CJDWRQLODFKPEL-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H6Cl2F4N2O2/c15-5-4-8(12(20)10(16)11(5)19)21-14(24)22-13(23)9-6(17)2-1-3-7(9)18/h1-4H,(H2,21,22,23,24)
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
Teflubenzuron - Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Veterinary substance
Substance group Benzoylurea
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Systemic, chitin synthesis inhibitor
CAS RN 83121-18-0
EC number -
CIPAC number 450
US EPA chemical code -
PubChem CID 91734
Molecular mass (g mol-1) 381.11
PIN (Preferred Identification Name) N-[(3,5-dichloro-2,4-difluorophenyl)carbamoyl]-2,6-difluorobenzamide
IUPAC name 1-(3,5-dichloro-2,4-difluorophenyl)-3-(2,6-difluorobenzoyl)urea
CAS name N-(((3,5-dichloro-2,4-difluorophenyl)amino)carbonyl)-2,6-difluorobenzamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 15
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Cydia pomonella
Plutella xylostella
Spodoptera exigua
Spodoptera littoralis
Trialeurodes vaporariorum
Physical state White to yellow crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
Example products using this active
  • Nemolt
  • Nomolt
  • Tefluron
  • Dart
  • Sag 134
UK LERAP status None (may vary with mixtures)
Formulation and application details Often supplied as a suspension concentrate that is mixed with water and used as a crop spray or as a feed pre-mix for animal use.


ENVIRONMENTAL FATE

for teflubenzuron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.01 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 8850 A5 - Acetone -
10 A5 - n-Heptane -
1060 A5 - Methanol -
740 A4 - Toluene -
Melting point (oC) 225 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 225 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.00 X 1004 Calculated -
Log P 4.3 A5 High
Bulk density (g ml-1)/Specific gravity 1.66 L3 -
Dissociation constant (pKa) at 25oC 9.2 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 9.16 X 10-04 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 6.98 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.47 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 249nm = 13543; [Acidic solution: 251nm = 15153; [Basic solution: 262nm = 21115 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 92 A5 Moderately persistent
DT50 (lab at 20oC) 92.1 A5 Moderately persistent
DT50 (field) 13.7 A5 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) 45.4 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 62.2-140.3 days; field studies DT50 range 8.8-16.4 days, DT90 range 29.2-53.2 days
Dissipation rate RL50 on plant matrix Value 24.5 R3 -
Note Pistachio leaves, n=1
Dissipation rate RL50 on and in plant matrix Value 9.4 R3 -
Note Tea, green leaves, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 10 A5 Moderately fast
Note Data for artificial light
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note pH sensitive: Stable at pH 5, 8.7 days at pH 9, at pH 7 95% of substance remained after 30 days
Water-sediment DT50 (days) 16.4 A5 Fast
Water phase only DT50 (days) 7.3 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 534 A5 Non-mobile
Koc 26062
Notes and range EU dossier Kd range 169-944 mL/g, koc range 21139-32556 mL/g, Soils=4
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
3,5-dichloro-2,4-difluorophenylurea This metabolite may cause environmental pollution, click here for further information Soil   0.107   Major fraction, Relevant
3,5-dichloro-2,4-difluoroaniline Soil   0.084   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2,6-difluorobenzoic acid - Plant - -
5-chloro-2,4-difluoroaniline - Plant - -
1-(3,5-dichloro-2,4-difluorophenyl)-3-(2,6-difluoro-3-hydroxybenzoyl)urea - Animal - -
1-(3,5-dichloro-2,4-difluorophenyl)-5-fluoro-4alpha,8aalpha-dihydroquinazoline-2,4(1H,3H)-dione - Water/sediment - -


ECOTOXICOLOGY

for teflubenzuron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 640 A5 Threshold for concern
CT50 (days) 0.8 -
Mammals - Acute oral LD50 (mg kg-1) > 5038 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 1 B5 Rat High
(ppm diet) > 100 -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 0.0065 A5 Lepomis macrochirus High
Fish - Chronic 21 day NOEC (mg l-1) 0.0186 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0028 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.000062 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 0.05 A5 Chironomus riparius High
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 0.02 A5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 100 A5 Moderate
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 72 A5 Moderate
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
A3 Typhlodromus pyri
-
Other arthropod (2) LR50 g ha-1 180 A5 Aphidius rhopalosiphi -
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2mg kg-1 soil, 28days
-
Mesocosm study data NOEAEC mg l-1 0.000005 A4 Aquatic invertebrates, NOEC -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for teflubenzuron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5038 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.04 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 A5 Mouse, SF=200 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.016 A5, SF=500 -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List II - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational Predicted exposure to workers is within acceptable levels
Potential risk to operators, PPE/PPC advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E3

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues No further information available
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for teflubenzuron

Language Name
English teflubenzuron
French teflubenzuron
German Teflubenzuron
Danish teflubenzuron
Italian teflubenzuron
Spanish teflubenzuron
Greek -
Slovenian teflubenzuron
Polish teflubenzuron
Swedish -
Hungarian teflubenzuron
Dutch teflubenzuron

Record last updated: Friday 01 May 2020
Contact: aeru@herts.ac.uk