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thiazopyr (Ref: MON 13200)
** RH 123652 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for thiazopyr

Description: A pre-emergence herbicide for annual grasses and some broad-leaved weeds

Example pests controlled: Barnyardgrass; Nutsedge; Canarygrass; Groundsel; Foxtail; Junglerice; Ragweed; London rocket; Shepherd's purse; Wild mustard

Example applications: Maize; Peanuts; Soybeans; Alfalfa

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1997, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Expired
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C16H17F5N2O2S
Canonical SMILES CC(C)CC1=C(C(=NC(=C1C(=O)OC)C(F)F)C(F)(F)F)C2=NCCS2
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) YIJZJEYQBAAWRJ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C16H17F5N2O2S/c1-7(2)6-8-9(15(24)25-3)11(13(17)18)23-12(16(19,20)21)10(8)14-22-4-5-26-14/h7,13H,4-6H2,1-3H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Pyridine
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Inhibits cell division. Microtubule assembly inhibition.
CAS RN 117718-60-2
EC number -
CIPAC number 8330
US EPA chemical code 129100
PubChem CID 91776
Molecular mass (g mol-1) 396.38
PIN (Preferred Identification Name) methyl 2-(difluoromethyl)-5-(4,5-dihydro-1,3-thiazol-2-yl)-4-(2-methylpropyl)-6-(trifluoromethyl)pyridine-3-carboxylate
IUPAC name methyl 2-difluoromethyl-5-(4,5-dihydro-1,3-thiazol-2-yl)-4-isobutyl-6-trifluoromethylnicotinate
CAS name methyl 2-(difluoromethyl)-5-(4,5-dihydro-2-thiazolyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) K1
Herbicide Resistance Classification (WSSA) 3
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Light tan crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Dow AgroSciences
  • Rohm and Haas Company
  • Monsanto
Example products using this active
  • Mandate
  • Visor
  • Spindle
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details -


ENVIRONMENTAL FATE

for thiazopyr

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 2.29 F4 Low
Solubility - In organic solvents at 20oC (mg l-1) 287000 F4 - Methanol -
30600 F4 - Hexane -
Melting point (oC) 77.3 F4 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 7.76 X 1003 Calculated -
Log P 3.89 F4 High
Bulk density (g ml-1)/Specific gravity 1.37 F4 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 0.27 L3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 4.75 X 10-02 V3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.70 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.12 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 64 L3 Moderately persistent
DT50 (lab at 20oC) 85 F3 Moderately persistent
DT50 (field) 274 F3 Persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Best available data, US EPA gives field DT50 of 111-437 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 7.8 F3 Moderately fast
Note Data for pH5
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable F4 -
Note Stable at all relevant pH's
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - F3 Moderately mobile
Koc 400
Notes and range Best available data
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2-(difluoromethyl)-5-(4,5-dihydro-2-thiazolyl)-4-(2-methyl-propyl)-6-(trifluorom ethyl)-3-pyridinecarboxylic acid - Soil (Aerobic) - -
5-cyano-2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoro-methyl)-3-pyridinecar boxylic acid - Soil (Aerobic) - -
5-(aminocarbonyl)-2-(difluoromethyl)-4-(2-methyl propyl)-6-(trifluoromethyl)-3-pyridinecarboxylic acid - Soil (Aerobic) - -
methyl 5-cyano-2-(difluoromethyl)-4-(2-methyl propyl)-6-(trifuloromethyl)-3-pyridinecarboxylate - Soil (Aerobic) - -


ECOTOXICOLOGY

for thiazopyr

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 F4 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 0.36 L2 Rat, 2 year High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 1814 F4 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 3.4 F4 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.092 L3 Pimephales promelas Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 6.1 J4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.11 F4 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 1.5 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.035 L3 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.04 L3 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) => 100 F4 Moderate
Earthworms - Acute 14 day LC50 (mg kg-1) 1000 L3 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for thiazopyr

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 F4 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 F4 Rat -
Mammals - Inhalation LC50 (mg l-1) > 1.2 F4 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Kidney, liver, thyroid and blood toxicant
USEPA - some evidence to suggest possible human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 None allocated at this time
EC Risk Classification Click here to view information omn the EU risk phrases Xi - Irritant; R36/37/38
N - Dangerous for the environment: R50
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for thiazopyr

Language Name
English thiazopyr
French thiazopyr
German Thiazopyr
Danish thiazopyr
Italian tiazopir
Spanish tiazopir
Greek -
Slovenian tiazopir
Polish tiazopyr
Swedish -
Hungarian -
Dutch -

Record last updated: Friday 25 May 2018
Contact: aeru@herts.ac.uk