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triticonazole (Ref: RPA 400727)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for triticonazole

Description: A seed treatment fungicide for the control of common soil and seed-borne diseases on cereals and other crops

Example pests controlled: Common bunt; Loose smut; Covered smut; Stem & crown rots; Blights; Powdery mildew; Scab; Anthracnose

Example applications: Cereals including wheat, barley, oats, rye, triticale; Turf; Ornamentals

Efficacy & activity: Efficacy demonstrated by field trials and extensive use

Availability status: Current

Introduction & key dates: 1993, first registered France

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Austria/UK
Date inclusion expires 31/04/2020
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule. The technical material is a racemate comprising equal amounts of (R)- and (S)-triticonazole
Chemical formula C17H20ClN3O
Canonical SMILES CC1(CCC(=CC2=CC=C(C=C2)Cl)C1(CN3C=NC=N3)O)C
Isomeric SMILES CC1(CC/C(=C\C2=CC=C(C=C2)Cl)/C1(CN3C=NC=N3)O)C
International Chemical Identifier key (InChIKey) PPDBOQMNKNNODG-NTEUORMPSA-N
International Chemical Identifier (InChI) InChI=1S/C17H20ClN3O/c1-16(2)8-7-14(9-13-3-5-15(18)6-4-13)17(16,22)10-21-12-19-11-20-21/h3-6,9,11-12,22H,7-8,10H2,1-2H3/b14-9-
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Triazole
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - methanol <3 g/kg damp product
Substance origin Synthetic
Mode of action Inhibits sterol demethylation. Sterol biosynthesis inhibitor.
CAS RN 131983-72-7
Alternative/old CAS RN 138182-18-0
EC number 603-543-7
CIPAC number 652
US EPA chemical code 125620
PubChem CID 6537961
Molecular mass (g mol-1) 317.82
PIN (Preferred Identification Name) rac-(1R,5E)-5-[(4-chlorophenyl)methylidene]-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentan-1-ol
IUPAC name (RS)-(E)-5-(4-chlorobenzylidene)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol
CAS name (5E)-5-[(4-chlorophenyl)methylene]-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 3
Examples of recorded resistance -
Physical state White powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Aventis
  • BASF
  • Bayer CropScience
  • Scotts
Example products using this active
  • Premis 25 FS
  • Kinto
  • Fungus Clear Ultra
UK LERAP status None (may vary with mixtures)
Formulation and application details Often supplied formulated as a flowable concentrate for seed treatment.


ENVIRONMENTAL FATE

for triticonazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 9.3 B5 Low
Solubility - In organic solvents at 20oC (mg l-1) 120 A5 - Hexane -
74500 A5 - Acetone -
18200 A5 - Methanol -
12600 A5 - Toluene -
Melting point (oC) 137 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 180 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.95 X 1003 Calculated -
Log P 3.29 A5 High
Bulk density (g ml-1)/Specific gravity 1.21 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 9.0 X 10-05 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.2 X 10-06 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.97 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.25 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral, acidic and basic solutions: 212nm = 23879, 263nm = 25731 A5 -
Surface tension (mN m-1) 72.0 A5 at 20 oC, 986g/Kg -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Not readily biodegradable
Soil degradation (days) (aerobic) DT50 (typical) 237 A5 Persistent
DT50 (lab at 20oC) 246 A5 Persistent
DT50 (field) 147.7 A5 Persistent
DT90 (lab at 20oC) 773 A5 -
DT90 (field) 580.6 A5 -
DT50 modelling endpoint - - -
Note EU 2018 dossier lab studies DT50 (normalised) range 109-565 days, DT90 (actual) range 381- >1000 days, Soils=14; Field studies DT50 (actual) range 36.1-242 days, DT90 (actual) range 329-803 days, Soils=9
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 300 A5 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 7.4 A5 Non-persistent
Note Stable at all relevant pHs
Water-sediment DT50 (days) Stable A5 -
Water phase only DT50 (days) Stable A5 -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - DW4 Moderately mobile
Koc 374
Notes and range -
Freundlich Kf 6.36 A5 Slightly mobile
Kfoc 569.8
1/n 0.900
Notes and range EU 2018 dossier kf range 3.67-13.4 mL/g, Kfoc range 290-871 mL/g, 1/n range 0.848-0.940, Soils=10
pH sensitivity Yes

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
(1R,3R,E)-3-(4-chlorobenzylidene)-5,5-dimethyl-1-((1H)-1,2,4-triazol-1-ylmethyl)-cyclopentan-1,3-diol (Ref: RPA 406341) This metabolite may cause environmental pollution, click here for further information Soil   0.202   Major fraction, Relevant
(E)-2-(4-chlorobenzylidene)-5,5-dimethyl-1-((1H)-1,2,4-triazol-1-ylmethyl)-cyclopentan-1,3-diol (Ref: RPA 404766) Soil   0.099   Minor fraction, Relevant
2-chloro-5((E)-((2RS)-2-hydroxy-3,3-dimethyl-2-(1H-1,2,4-triazole-1-ylmethyl)cyclopentylidenc)methyl)phenol (Ref: RPA 407922) This metabolite may cause environmental pollution, click here for further information Soil   0.128   Major fraction, Not relevant
(1RS, 5Z)-5-(4-chlorobenzylidence)-2-2-dimethyl-1-(1H-1,2,4-triazole-1-ylmethyl)cyclopentanol (Ref: RPA 406203) This metabolite may cause environmental pollution, click here for further information Soil   0.110   Major fraction, Relevant


ECOTOXICOLOGY

for triticonazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 94 A5 Low potential
CT50 (days) 3 -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 21 B5 Rat High
(ppm diet) > 250 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 693 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 3.6 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.01 A4 Oncorhynchus mykiss, 28 day Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 9.0 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.092 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.08 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 1.1 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 1.0 B5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Apis mellifera Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 92.26 A5 Apis mellifera Moderate
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) > 125 A5 Eisenia foetida, 56day, corr Low
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 86 Mortality
Dose: 0.1 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 0
0
Mortality
Fecundity
Dose: 0.1 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.167 mg kg-1 dw soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for triticonazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.61 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.025 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.05 A5 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) 0.05 A5 Rabbit, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.025 A4 Dog, 1 year, SF=100 -
Dermal penetration studies (%) 1-3 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; A5 -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Possible liver and adrenals toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R51, R53
EC Safety Classification Click here to view information omn the EU safety phrases S61
WHO Classification III - Slightly hazardous
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for triticonazole

Language Name
English triticonazole
French triticonazole
German Triticonazol
Danish triticonazol
Italian triticonazolo
Spanish triticonazol
Greek -
Slovenian tritikonazol
Polish tritikonazol
Swedish tritikonazol
Hungarian tritikonazol
Dutch -

Record last updated: Saturday 29 June 2019
Contact: aeru@herts.ac.uk