Acifluorfen (Ref: RH 5781)
Last updated: 01/09/2023
(Also known as: acifluorofen; acifluorfen metabolite; lactofen metabolite; PPG 847; carbofluorfen)
Acifluorfen is a post-emergence herbicide, usually used as the sodium salt. It is highly soluble in water, with a low vapour pressure and may be moderately persistent in soils and water depending upon conditions. Based on its chemical properties it has a high potential for leaching to groundwater. It has a low to moderate toxicity to most biodiversity. It is not highly toxic to human but is known to be a skin and eye irritant.
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Post emergence herbicide, usually used as the sodium salt; particularly effective against broad-leaved weeds and grasses. Also a pesticide transformation product.
Carpetweed; Balloonvine; Wild buckwheat; Cocklebur; Ladysthumb; Lambsquarters; Copperleaf; Morning glory; Moonflower; Nightshade; Pigweed; Foxtails
Soybean; Peanuts; Rice
-
Current
1980, USA
Not approved
Expired
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not approved
Not applicable
Expired
Not applicable
Yes
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
ISIceland
NONorway
 
 
 
 
 
 
 
 
 
None
C₁₄H₇ClF₃NO₅
C1=CC(=C(C=C1C(F)(F)F)Cl)OC2=CC(=C(C=C2)[N+](=O)[O-])C(=O)O
No data
NUFNQYOELLVIPL-UHFFFAOYSA-N
InChI=1S/C14H7ClF3NO5/c15-10-5-7(14(16,17)18)1-4-12(10)24-8-2-3-11(19(22)23)9(6-8)13(20)21/h1-6H,(H,20,21)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
acifluorfen
-
Herbicide, Metabolite
Soil
Nitrophenyl ether herbicide
-
-
Synthetic
Contact action. Inhibition of protoporphyrinogen oxidase (PPO).
50594-66-6
256-634-5
497
114401
44073
604-041-00-0
361.66
5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid
5-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-2-nitrobenzoic acid
5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid
Chemical subject to PIC regulations; Potential groundwater pollutant; PAN Bad Actor
-
E
14
Not applicable
Not applicable
-
Off-white coloured solid
Rohm and Haas United Phosphorus
-
250000
High
50000
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source
Acetone
-
1000
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source
n-Hexane
-
155
-
-
-
-
235
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
-
-
-
1.51 X 1001
Calculated
-
1.18
Low
-
-
-
-
-
-
-
-
-
3.86
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
-
Weak acid
0.133
Low volatility
-
-
-
-
-
-
-
-
-
-
54
Moderately persistent
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Other sources: DT₅₀ 108 (silt loam) - 200 (clay) days (R3)
-
-
-
-
-
-
-
-
4
Moderately fast
-
Stable
Stable
-
-
-
-
-
-
-
Soil adsorption and mobility
-
Moderately mobile
113
-
13.2
R4 R = Peer reviewed scientific publications 4 = Verified data
Moderately mobile
160
1.05
Literature data: Kf range 0.57-43.11 mL g⁻¹, Kfoc range 65.3-291.3 mL.g, 1 /n range 0.952-1.190, Soils=5
-
3.11
Calculated
High leachability
3.53 X 10-01
Calculated
-
-
Medium
Calculated
-
Moderately mobile
Calculated
-
Low risk
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Based on LogP < 3
Low risk
-
-
None
Terrestrial ecotoxicology
1370
Rat
Moderate
-
-
-
-
-
-
-
-
2821
Anas platyrhynchos
Low
-
-
-
-
-
-
> 1800
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Eisenia foetida as sodium salt
Low
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
> 100
Low
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
54
Oncorhynchus mykiss
Moderate
-
-
-
28
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Daphnia magna
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
1370
Rat
Moderate
2000
Rabbit
-
6.9
Rat 4 hr
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
EU MRL pesticide database 
-
-
-
-
-
-
-
-
-
-
Carcinogen
Endocrine disruptor
?Possibly, status not identified
A3 A = Chromosome aberration (EFSA database) 3 = Negative
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Slightly toxic Liver, heart, and kidney toxicant at high doses Published studies suggest substance is carcinogenic
Not expected to auto-ignite; Not highly flammable
Health: H302, H315, H318 Environment: H400, H410
II (Moderately hazardous)
-
-
-
acifluorfen
-
-
acifluorfen
-
acifluorfen
-
acifluorfen
-
acifluorfen
-
-
Record last updated:
01/09/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242