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boscalid (Ref: BAS 510F)
** nicobifen ** BAS 510 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for boscalid

Description: A fungicide active against a broad range of fungal pathogens in a wide range of crops including vegetables and other crops

Example pests controlled: Alternaria blight; Botrytis; Powdery mildew; Purple blotch; Rust; Leaf spot; Target spot; Grey mould; Stem rot

Example applications: Vegetables including beans, brassicas, onions, garlic, shallots, peas, carrots, turnips; Soybeans; Fruits including grapes, apples, pears, strawberries; Tree nuts

Efficacy & activity: Soybean/Brown spot=High; Soybean/White mould=Moderate

Availability status: Current

Introduction & key dates: 2002, Chile, Korea and UK; 2003, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Slovakia/France
Date inclusion expires 31/07/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia; USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C18H12Cl2N2O
Canonical SMILES C1=CC=C(C(=C1)C2=CC=C(C=C2)Cl)NC(=O)C3=C(N=CC=C3)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) WYEMLYFITZORAB-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C18H12Cl2N2O/c19-13-9-7-12(8-10-13)14-4-1-2-6-16(14)22-18(23)15-5-3-11-21-17(15)20/h1-11H,(H,22,23)/f/h22H
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Carboxamide
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier - none declared
Substance origin Synthetic
Mode of action Protectant, foliar absorption, translocates, inhibits spore germination and germ tude elongation. Succinate DeHydrogenase Inhibitor.
CAS RN 188425-85-6
EC number -
CIPAC number 673
US EPA chemical code 128008
PubChem CID 213013
Molecular mass (g mol-1) 343.21
PIN (Preferred Identification Name) 2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)pyridine-3-carboxamide
IUPAC name 2-chloro-N-(4'-chlorobiphenyl-2-yl)nicotinamide
CAS name 2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)-3-pyridinecarboxamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 7
Examples of recorded resistance -
Physical state White crystalline powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
  • Goldengrass
Example products using this active
  • Filan
  • Signum
  • Splice
  • Tracker
  • Venture
  • Emerald
  • Bosco WG
UK LERAP status None
Formulation and application details Often supplied as soluble granules which are mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for boscalid

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 4.6 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 22500 A5 - Toluene -
10000 A5 - 1-Octanol -
45000 A5 - Methanol -
180000 A5 - Acetone -
Melting point (oC) 140 A5 -
Boiling point (oC) Decomposes before boiling V3 -
Degradation point (oC) 300 A4 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable V3 -
Octanol-water partition coefficient at pH 7, 20oC P 9.12 X 1002 Calculated -
Log P 2.96 A5 Moderate
Bulk density (g ml-1)/Specific gravity 1.381 A5 -
Dissociation constant (pKa) at 25oC Not applicable E4 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.00072 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 5.18 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.99 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.34 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 207nm = 31534, 228nm= 19834, 290nm = 1529, 300nm = 531 A5 -
Surface tension (mN m-1) 73.6 A5 20 degC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Not readily biodegradable
Soil degradation (days) (aerobic) DT50 (typical) 484.4 A5 Very persistent
DT50 (lab at 20oC) 484.4 A5 Very persistent
DT50 (field) 254 A5 Persistent
DT90 (lab at 20oC) 442 A4 -
DT90 (field) 1000 A5 -
DT50 modelling endpoint - - -
Note EU 2018 dossier lab studies DT50 (normalised) range 103.3-1214.4 days, Soils=9; field studies DT50 (normalised) range 196-312.2 days, DT90 (actual) >1000 days; Other Literature values DT50 range 27 to 372 days (R3)
Dissipation rate RL50 on plant matrix Value 6.9 R4 -
Note Published literature RL50 range 5.3-8.5 days, 2 field crops, various matrices, n=2
Dissipation rate RL50 on and in plant matrix Value 5.1 R4 -
Note Published literature RL50 range 1.3-11.0 days, 5 field and undercover grown crops, various matrices, n=7
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Not a significant degradation route
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 4 to pH 9
Water-sediment DT50 (days) 545 A5 Stable
Water phase only DT50 (days) 5 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 12.6 A5 Slightly mobile
Kfoc 772
1/n 0.864
Notes and range EU dossier Kf range 3.3-27.8 mL/g, Kfoc range 507-1110 mL/g, 1/n range 0.839-0.887, Soils=6
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
N-(4-chlorobiphenyl-2-yl)-2-hydroxynicotinamide (Ref: M510F49) This metabolite may cause environmental pollution, click here for further information Soil   0.145   Major fraction; Relevant


ECOTOXICOLOGY

for boscalid

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 107 A5 Threshold for concern
CT50 (days) 1.0 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 R4 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 5 L3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5000 ppm A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 2.7 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.125 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 5.33 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 1.3 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 3.75 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 200 A5 Apis mellifera Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 166 A5 Apis mellifera Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 1.2 A5 Eisenia foetida, corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 3600 >
A5 Typhlodromus pyri
-
% Effect 0 Mortality
A5 Typhlodromus pyri
-
Other arthropod (2) LR50 g ha-1 3600 >
A5 Aphidius rhopalosiphi
-
% Effect 11 Mortality
A5 Aphidius rhopalosiphi
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 6 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for boscalid

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 R4 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 R4 Rat -
Mammals - Inhalation LC50 (mg l-1) > 6.7 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.04 A5 Rat, SF=100; BA5; EU 2008 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) Not allocated BA5; EU 2008 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) Not allocated A5 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.1 A5 Dog, SF=44; BA5; EU 2008 -
Dermal penetration studies (%) 2-7 A5 Concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Acceptable for intended risks
Occupational Occupational exposure may occur through inhalation and dermal contact
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

General human health issues Liver and thyroid toxicant
USEPA - some evidence to suggest possible human carcinogen
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for boscalid

Language Name
English boscalid
French boscalid
German Boscalid
Danish boscalid
Italian boscalid
Spanish boscalid
Greek -
Slovenian boskalid
Polish boskalid
Swedish boskalid
Hungarian -
Dutch boscalid

Record last updated: Tuesday 02 July 2019
Contact: aeru@herts.ac.uk