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GET ADDITIONAL DATA HERE!

methyl isothiocyanate (Ref: SN-32866)
** methyl mustard oil ** MITC ** isothiocyanic acid methyl ester ** MIT ** R014821 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for methyl isothiocyanate

Description: A highly toxic multipurpose soil fumigant. Also a pesticide transformation product and used in the production of many pesticides and other chemicals.

Example pests controlled: Nematodes; Various soil insects; Fungal pathogens; Weed seeds

Example applications: -

Efficacy & activity: -

Availability status: Unknown

Introduction & key dates: -

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C2H3NS
Canonical SMILES CN=C=S
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) LGDSHSYDSCRFAB-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C2H3NS/c1-3-2-4/h1H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Metabolite, Fungicide, Nematicide, Herbicide, Insecticide
Metabolite Type Soil
Substance group Unclassified
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Fumigant with contact action
CAS RN 556-61-6
EC number 209-132-5
CIPAC number -
US EPA chemical code 068103
PubChem CID 11167
Molecular mass (g mol-1) 73.11
PIN (Preferred Identification Name) -
IUPAC name methyl isothiocyanate
CAS name isothiocyanatomethane
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not known
Examples of recorded resistance -
Physical state Colourless crystalline solid
Related substances & organisms -

Can be a metabolite of:
Parent Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
metam-sodium Soil   0.829   Major fraction, Relevant
dazomet Soil   0.740   Major fraction, Relevant
metam-potassium Soil   0.829   Major fraction, Relevant
imazalil Soil   0.096   Minor fraction, Relevant

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Schering
Example products using this active
  • Trapex
UK LERAP status Not applicable
Formulation and application details Usually supplied as an emulsifiable concentrate.


ENVIRONMENTAL FATE

for methyl isothiocyanate

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 8940 A5 High
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) 35 E3 -
Boiling point (oC) 119 V3 -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.12 X 1001 Calculated -
Log P 1.05 A5 Low
Bulk density (g ml-1)/Specific gravity 1.07 E3 -
Dissociation constant (pKa) at 25oC 12.3 Q3 -
Note: Strong base
Vapour pressure at 20oC (mPa) 1739000 A5 Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1) 14.2 A5 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.21 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.28 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral soln: 235nm=635, 283nm=65, 321nm=17
Alkaline soln: 276nm=46, 320nm=5, 290nm=>10
Acidic soln: 235nm=635, 283nm=23, 290nm=>10
A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 2.63 A4 Non-persistent
DT50 (lab at 20oC) 2.63 A5 Non-persistent
DT50 (field) 2.1 A5 Non-persistent
DT90 (lab at 20oC) 11.2 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier (metam) lab studies DT50 range: 0.97-8.31 days, DT90 range 3.2-27.6 days; field studies DT50 range 1.3-20.3 days; EU dossier (dazomet) lab studies range 5-32.7 days; Other literature studies Lab range - 24 soils, nursery and forest, various app rates
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 6 K2 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 50 A3 Moderately persistent
Note -
Water-sediment DT50 (days) 0.37 A5 Fast
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 0.35 A5 Very mobile
Kfoc 13.5
1/n 0.830
Notes and range EU dossier Kf range 0.21-0.43, Kfoc range 9.0-20.2ml/g, 1/n range 0.755-9.05, Soils=5
pH sensitivity No


ECOTOXICOLOGY

for methyl isothiocyanate

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 2.6 K2 Estimated Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 147 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 136 V3 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.0531 A5 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) 0.005 A5 Oncorhynchus mykiss, 28 day High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.076 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.00625 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.59 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.58 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) > 0.125 L2 Unknown species Moderate
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 4.0 A5 Eisenia foetida High
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for methyl isothiocyanate

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 147 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 1290 A5 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 0.54 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.004 / 0.001 A5 Dog, SF=100 / variable data across EU dossiers -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.03 A5 Rat -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.004 A5 Rat -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Some bystander risk identified via spray drift exposure
Occupational May be fatal if absorbed through the skin
Respiratory equipment required to mitigate risk
Risks identified in glasshouse environments
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 A5 EU Dir 89/778/EC limit -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

A2; B1; C3; D0; E0

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Highly toxic by ingestion
Harmful via skin exposure and inhalation
Possible thyroid toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Corrosive
Not explosive or oxidising
CLP classification 2013 Health: H301, H314; H317; H331
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R23/25
Xn - Harmful: R21
C - Corrosive: R34
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S36/37/39, S38, S45, S60, S61
WHO Classification II - Moderately hazardous
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for methyl isothiocyanate

Language Name
English methyl isothiocyanate
French isothiocyanate de methyle
German Methylisothiocyanat
Danish methylisothiocyanat
Italian Isotiocianato di metile
Spanish isotiocianato de metilo
Greek -
Slovenian metil izotiocianat
Polish metyloizotiocyjanian
Swedish -
Hungarian -
Dutch methylisothiocyanaat

Record last updated: Tuesday 25 June 2019
Contact: aeru@herts.ac.uk