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bromadiolone (Ref: LM 637)
** broprodifacoum ** bromodiolone ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for bromadiolone

Description: An anti-coagulant coumarin-derivative rodenticide mainly used for indoor applications

Example pests controlled: Rats; Mice

Example applications: Houses; Commercial buildings; Industrial sites

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1976, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Italy/Romania
Date inclusion expires 31/05/2021
EU Candidate for substitution (CfS) Yes - low ADI / ARfD / AOEL
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule which is a mixture of the two isomeric diastereomers (1RS,3RS) and (1RS,3SR) both of which are toxicologically active
Chemical formula C30H23BrO4
Canonical SMILES C1=CC=C(C=C1)C(CC(C2=CC=C(C=C2)C3=CC=C(C=C3)Br)O)C4=C(C5=CC=CC=C5OC4=O)O
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) OWNRRUFOJXFKCU-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C30H23BrO4/c31-23-16-14-20(15-17-23)19-10-12-22(13-11-19)26(32)18-25(21-6-2-1-3-7-21)28-29(33)24-8-4-5-9-27(24)35-30(28)34/h1-17,25-26,32-33H,18H2
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Rodenticide
Substance group Coumarin anticoagulant
Minimum active substance purity 970
Known relevant impurities EU dossier - none declared
Substance origin Synthetic
Mode of action Second generation anticoagulant which blocks prothrombin formation, inhibits blood coagulation
CAS RN 28772-56-7
EC number 249-205-9
CIPAC number 371
US EPA chemical code 112001
PubChem CID 54680085
Molecular mass (g mol-1) 527.40
PIN (Preferred Identification Name) 3-[(1E,3E)-3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-1-benzopyran-2-one
IUPAC name 3-[(1RS,3RS;1RS,3SR)-3-(4'-bromobiphenyl-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxycoumarin
CAS name 3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-1-benzopyran-2-one
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Odourless white powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Certis
  • Killgerm
  • Luxan
  • LiphaTech
Example products using this active
  • Maki
  • Coumarin
  • Tomcat
  • Sarakat Bromabait
  • Contrac
  • Bromone
  • Maki
  • Super-Caid
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied in ready-to-use bait formulations such as granules, blocks and pellets.


ENVIRONMENTAL FATE

for bromadiolone

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 18.4 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 10000 A5 - Ethyl acetate -
12000 A4 - Acetone -
8200 C4 - Ethanol -
5600 C4 - Methanol -
Melting point (oC) 199 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 200 L3 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.17 X 1004 Calculated -
Log P 4.07 A4 High
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC 4.04 V3 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 2.13 X 10-05 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 8.99 X 10-07 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.90 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.04 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 206-214nm = 74211, 260-266nm = 29157, 312-314nm = 13895; [Acidic solution: 206-214nm = 64736, 250-266nm = 33316, 313-314nm = 12263; [Alkaline solution: 206-214nm = 127895, 260-266nm = 28526, 312-314nm = 13895 A5 -
Surface tension (mN m-1) 71.2 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 53 C4 Moderately persistent
DT50 (lab at 20oC) 14 A5 Non-persistent
DT50 (field) 4.6 F4 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier Lab studies DT50 range 2.8-269 days, DT90 range14-658 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 0.1 C4 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 30 C4 Moderately persistent
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 7.9 A3 Slightly mobile
Kfoc 1636
1/n 0.77
Notes and range EU dossier Kd range 5.3-10.4 mL/g, Kfoc range 1563-1709 mL/g, 1/n range 0.652-0.887, Soils=2
pH sensitivity Lower adsoption under alkaline conditions than under acidic.

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
3-[(1RS)-3-(4'-bromobiphenyl-4-yl)-3-oxo-1-phenylpropyl]-4-hydroxy-2H-chromen-2-one
Note: Moderately persistent
bromadiolone ketone Soil 0.40 -
(1RS,3RS)-5-(4'-bromobiphenyl-4-yl)-1,3-diphenylpentan-1-ol - Soil 0.19 -
(1RS,3RS,5RS)-1-(4'-bromobiphenyl-4-yl)-3,5-diphenylpentane-1,5-diol - Soil 0.25 -


ECOTOXICOLOGY

for bromadiolone

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 867 Q2 Estimated Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 0.56 A5 Rat High
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 138 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 8.0 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 2 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.017 A5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 4.74 A5 High
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for bromadiolone

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 0.56 A5 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) > 1.30 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.0043 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) Not relevant A3 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) Not relevant A3 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.0012 A4 Rabbit, SF=857 -
Dermal penetration studies (%) 1.6 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Small risk identified from possible bait contact
Occupational Absorbed from the gastrointestinal tract, from intact skin, and the respiratory system - PPE/PPC advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.016 A5 -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

A3; B0; C3; D0; E3

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Anticoagulant and may cause haemorrhaging
It is very toxic by inhalation, contact with the skin and by ingestion
Slight eye irritant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not oxidising or explosive
CLP classification 2013 Health: H300, H310, H330, H360d, H372
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R21, R22
EC Safety Classification Click here to view information omn the EU safety phrases S13, S21/22, S24, S36/37, S46
WHO Classification Ia - Extremely hazardous
UN Number 3027
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for bromadiolone

Language Name
English bromadiolone
French bromadiolone
German Bromadiolon
Danish bromadiolon
Italian bromadiolone
Spanish bromadiolona
Greek -
Slovenian bromadiolon
Polish bromadiolon
Swedish bromadiolon
Hungarian -
Dutch bromadiolon

Record last updated: Tuesday 29 October 2019
Contact: aeru@herts.ac.uk