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GET ADDITIONAL DATA HERE!

bromuconazole (Ref: LS 860263)
** bromoconazole ** LS 850646 ** LS 850647 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for bromuconazole

Description: A foliar applied conazole fungicide for a range of crops including cereals

Example pests controlled: Rusts; Powdery mildew; Septoria tritici; Leaf spot; Eyespot

Example applications: Cereals including barley, wheat; Fruit; Vegetables; Grapevines; Turf; Ornamentals

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1990, first reported; 1992, first marketed France

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Belgium/Czech Republic
Date inclusion expires 31/01/2024
EU Candidate for substitution (CfS) Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule - isomeric mixture of the cis- and trans-form
Chemical formula C13H12BrCl2N3O
Canonical SMILES C1C(COC1(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl)Br
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) HJJVPARKXDDIQD-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C13H12BrCl2N3O/c14-9-4-13(20-5-9,6-19-8-17-7-18-19)11-2-1-10(15)3-12(11)16/h1-3,7-9H,4-6H2
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Triazole
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic. Sterol biosynthesis inhibitor.
CAS RN 116255-48-2
EC number 408-060-3
CIPAC number 680
US EPA chemical code 120503
PubChem CID 3444
Molecular mass (g mol-1) 377.06
PIN (Preferred Identification Name) 1-{[(2?,4?)-4-bromo-2-(2,4-dichlorophenyl)oxolan-2-yl]methyl}-1H-1,2,4-triazole
IUPAC name 1-[(2RS,4RS;2RS,4SR)-4-bromo-2-(2,4-dichlorophenyl)tetrahydrofurfuryl]-1H-1,2,4-triazole
CAS name 1-[[4-bromo-2-(2,4-dichlorophenyl)tetrahydro-2-furanyl]methyl]-1H-1,2,4-triazole
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 3
Examples of recorded resistance -
Physical state White to beige powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
  • Interfarm
Example products using this active
  • Grannit 200SC
  • Jazz
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often available as suspension concentrate that is diluted with water and used as a spray.


ENVIRONMENTAL FATE

for bromuconazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 48.3 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 1790 A5 - n-Hexane -
187000 A5 - Toluene -
269.2 A5 - Acetone -
50000 A5 - n-Octanol -
Melting point (oC) 84 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 194 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.74 X 1003 Calculated -
Log P 3.24 A5 High
Bulk density (g ml-1)/Specific gravity 1.72 A5 -
Dissociation constant (pKa) at 25oC 2.75 A5 -
Note: Strong acid, pKa (2) -4.02 Very strong acid
Vapour pressure at 20oC (mPa) 0.004 A5 - @ 25 degC Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.31 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 3.02 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.50 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 202.5nm = 43936, 220nm = 10762; [Acidic solution: 202.5nm = 38527, 220nm = 11157; [Basic solution: 221.5nm = 9915 A5 -
Surface tension (mN m-1) 59.8 A5 at 21oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 190 B5 Persistent
DT50 (lab at 20oC) 679 A5 Very persistent
DT50 (field) 123 A3 Persistent
DT90 (lab at 20oC) 2253 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 329-1028 days, DT90 range 1091-3414 days; Various other studies lab range 119-1279 days, field studies DT50 range 5-214 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note No photolytic degradation in pH range 5 to 9
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 30 A5 Moderately persistent
Note Not sensitive to pH
Water-sediment DT50 (days) 275 A5 Slow
Water phase only DT50 (days) 1.7 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - A5 Slightly mobile
Koc 872
Notes and range EU dossier Koc range isomer LS850646 range 474-1086, LS850647 range 627-1539 mL/g, Soils=4
Freundlich Kf 12.51 B5 Slightly mobile
Kfoc 860
1/n 0.82
Notes and range UK dossier Kf range 4.75-32.0 mL/g, Kfoc range 575-1333 mL/g, 1/n - no data, Soils=4
pH sensitivity No

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: LS850920) hydroxylated metabolite Plant - -
1-[2-(2,4-dichlorophenyl)-2,5-dihydrofuran-2-ylmethyl]-1H-1,2,4-triazole
(Ref: LS860364)
- Rat; Plant; Soil; Fish - -
(Ref: LS860550) 3-hydroxy metabolite Plant - -
(Ref: LS860551) 3-hydroxy metabolite Plant - -
(Ref: LS870353) 2-ketone metabolite Plant - -
2-(2,4-dichlorophenyl-2-(1,2,4-triazol-1-yl methyl)) tetrahydrofuran
(Ref: LS871387)
- Soil (Anaerobic, dark) - -
(Ref: RPA 401527) 5-H-2-ketone metabolite Plant - -
(Ref: RPA 406117) hydroxylated metabolite Plant - -


ECOTOXICOLOGY

for bromuconazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 131 P4 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 328 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 0.99 B4 Rat High
(ppm diet) 20 -
Birds - Acute LD50 (mg kg-1) > 2150 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 1.7 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.21 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 8.9 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.02 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.250 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 3.125 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.12 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 3.3 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 500 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 18.6 A5 Eisenia foetida, corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect -19.2 Beneficial capacity
Dose: 62.5 mL/ha
A5 Aphidius rhopalosiphi, adults
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect -35.3 Beneficial capacity
Dose: 62.5 mL/ha
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.667 mg kg-1, 28days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for bromuconazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 328 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A4 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.0 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.025 A5 Dog, SF=100 -
Dermal penetration studies (%) 5.0-45.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Acceptable risks for proposed uses
Occupational Acceptable risks for proposed uses with PPE
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E2

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Moderately toxic
Possible liver toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H302+H312, H225, H319
EC Risk Classification Click here to view information omn the EU risk phrases Reproduction risk category 3: R63
Xn - Harmful: R22
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification II - Moderately hazardous
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for bromuconazole

Language Name
English bromuconazole
French bromuconazole
German Bromuconazol
Danish bromuconazol
Italian bromuconazolo
Spanish bromuconazol
Greek -
Slovenian bromukonazol
Polish bromukonazol
Swedish -
Hungarian bromukunazol
Dutch -

Record last updated: Tuesday 25 June 2019
Contact: aeru@herts.ac.uk