| famphur (Ref: ENT 25644 ) |
 |
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GENERAL INFORMATION 
for famphur
Description: An obolete substance used as an insecticide for lice and grubs particularly those affecting cattle and other horned animals.
Availability status: -
Introduction & key dates: -
Examples of species treated: Horned animals
Chemical structure:
| Isomerism | - |
| Chemical formula | C10H16NO5PS2 |
| Canonical SMILES | CN(C)S(=O)(=O)C1=CC=C(C=C1)OP(=S)(OC)OC |
| Isomeric SMILES | No data |
| International Chemical Identifier key (InChIKey) | JISACBWYRJHSMG-UHFFFAOYSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C10H16NO5PS2/c1-11(2)19(12,13)10-7-5-9(6-8-10)16-17(18,14-3)15-4/h5-8H,1-4H3 |
| 2D structure diagram/image available? | Yes |
General status:
| Veterinary substance type | Insecticide, Antiparasitic | |||
| Substance group | Organophosphate | |||
| Minimum active substance purity | - | |||
| Known relevant impurities | - | |||
| Substance origin | Synthetic | |||
| Mode of action | Systemic, acetylcholine esterase inhibitor | |||
| Molecular targets | Cholinesterase, inhibitor | |||
| CAS RN | 52-85-7 | |||
| EC number | 200-154-0 | |||
| CIPAC number | - | |||
| US EPA chemical code | 059901 | |||
| PubChem CID | - | |||
| ATCvet Code | Not listed | |||
| Therapeutic Class | None | |||
| Controlled Drug? | No | |||
| Regulation 37/2010 MRL Classification | No data | |||
| Molecular mass (g mol-1) | 325.34 | |||
| PIN (Preferred Identification Name) | - | |||
| IUPAC name | O-4-dimethylsulfamoylphenyl O,O-dimethyl phosphorothioate | |||
| CAS name | O-[4-[(dimethylamino)sulfonyl]phenyl] O,O-dimethyl phosphorothioate | |||
| Other status information | PAN Bad Actor; Evidence of use in third world countries | |||
| Relevant Environmental Water Quality Standards | - | |||
| Physical state | Colourless crystalline powder | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Product | Manufacturer | Authorisation Route | UK Legal Class |
| Example products using this active | None identified | None identified | No UK authorisation for use with animals | Not applicable |
| Formulation and application details | Usually applied topically. | |||
ENVIRONMENTAL FATE
for famphur
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 100 | F3 | Moderate | |
| Solubility - In organic solvents at 20oC (mg l-1) | ||||
| 300000 | L3 - Xylene | - | ||
| 23000 | L3 - Isopropanol | - | ||
| Melting point (oC) | 53 | F4 | - | |
| Boiling point (oC) | - | - | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | - | - | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 1.70 X 1002 | Calculated | - |
| Log P | 2.23 | V3 | Low | |
| Bulk density (g ml-1)/Specific gravity | - | - | - | |
| Dissociation constant (pKa) at 25oC | - | - | - | |
| Note: | ||||
| Vapour pressure at 20oC (mPa) | 0.181 | V3 - @ 25 degC | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 1.63 X 10-03 | V3 - @ 25 degC | Non-volatile | |
GUS leaching potential index  |
- | - | - | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
| Refractive Index | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Soil degradation (days) (aerobic) | DT50 (typical) | - | - | - |
| DT50 (lab at 20oC) | - | - | - | |
| DT50 (field) | - | - | - | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| Note: | - | |||
| Manure DT50 (days) | - | - | - | |
| Aqueous photolysis DT50 (days) at pH 7 | Value | - | - | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 115 | CA3 | Persistent |
| Note | pH sensitive, DT50 60 days at pH 10 | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | - | - |
| Koc | - | |||
| Notes and range | - | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
Other known metabolites:
| Metabolite name and reference | Aliases | Formation medium / Rate | Estimated maximum occurrence fraction | Metabolising enzymes |
| famphur oxon Note: CAS 960-25-8 |
- | - | - | - |
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | - | - | - |
| CT50 (days) | - | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 48 | F4 Rat | High | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | - | - |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | 9.87 | CA3 Anas platyrhynchos | High | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 4.9 | R3 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | 2.1 | R3 Oncorhynchus mykiss | Moderate | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | - | - | - | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | - | - | - | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees (Apis spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | > 0.414 | Q3 | High | |
| Bumblebees (Bombus spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| - | ||||
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| - | ||||
| Mason bees (Osmia spp.) | Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - |
| Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) | - | - | - | |
| Other pollinators (1) | Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) | - | - | - |
| Mode of exposure | - | |||
| Other pollinators (2) | Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) | - | - | - |
| Mode of exposure | - | |||
| Earthworms - Acute 14 day LC50 (mg kg-1) | - | - | - | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for famphur
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 48 | F4 Rat | High | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | > 400 | V3 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | - | - | - | |
| Other Mammal toxicity endpoints | Intraperitoneal LD50 = 11.6 mg kg-1 | V3 Mouse | - | |
| Intramuscular LD50 = 64 mg kg-1 | V3 Mouse | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | - | - | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | List I | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | Occupational exposure may result via dermal contact | |||
| Elimination route and rate | Rapidly metabolised in mammals and metabolites eliminated in the urine | R4 | - | |
Health issues:
| Carcinogen | Genotoxic | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
|
A0; B0; C0; D0; E0 | - |
- |
|
|
|||
| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
- |
|
- |
|
- |
|
|||
| General human health issues | No further information available | |||||||
| Key: Genotoxicity A: Chromosome aberration (EFSA database) B: DNA damage/repair (EFSA database) C: Gene mutation (EFSA database) D: Genome mutation (EFSA database) E: Unspecified genotoxicity type (miscellaneous data source) 0: No data 1: Positive 2: Mixed/ambiguous results 3: Negative |
Key: Other : Yes, known to cause a problem  : No, known not to cause a problem  : Possibly, status not identified - : No data found |
|||||||
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
IMDG Transport Code is 6.1 | |||
| CLP classification 2013 | - | |||
| EC Risk Classification |
- | |||
| EC Safety Classification |
- | |||
| WHO Classification | Ib | - | Highly hazardous | |
| UN Number | 2783 | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | famphur |
| French | - |
| German | - |
| Danish | - |
| Italian | - |
| Spanish | - |
| Greek | - |
| Slovenian | - |
| Polish | - |
| Swedish | - |
| Hungarian | - |
| Dutch | - |
Record last updated: Monday 02 April 2018
Contact: aeru@herts.ac.uk