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sulfadiazine
** adiazine ** diazolone ** SDZ ** SDA ** sulfanilamidopyrimidine ** sulfapyrimidine ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for sulfadiazine

Description: A commonly used synthetically produced livestock antibiotic / antimicrobial with antiparasitic properties

Availability status: -

Introduction & key dates: circa 1935, discovered

Examples of species treated: Dogs, Cats, Horses, Cattle, Poultry, Pigs

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C10H10N4O2S
Canonical SMILES C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) SEEPANYCNGTZFQ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Veterinary substance type Antiparasitic, Antibacterial, Coccidiostat, Antiprotozoal
Substance group Sulfonamide
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action inhibits the production of folic acid necessary for the growth and multiplication of bacteria
Molecular targets Dihydropteroate synthetase, antagonist
CAS RN 68-35-9
EC number 200-685-8
CIPAC number -
US EPA chemical code -
PubChem CID -
ATCvet Code QJ01EW10
Therapeutic Class Antiinfectants for systemic use: Antibacterials for systemic use
Controlled Drug? No
Regulation 37/2010 MRL Classification Allowed substance (Table 1: All food producing species)
Molecular mass (g mol-1) 250.278
PIN (Preferred Identification Name) -
IUPAC name 4-amino-N-pyrimidin- 2-yl-benzenesulfonamide
CAS name 4-amino-N-2-pyrimidinylbenzenesulfonamide
Other status information Potential groundwater pollutant
Relevant Environmental Water Quality Standards -
Physical state White to slightly yellow crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Product Manufacturer Authorisation Route UK Legal Class
Example products using this active Cotrimoxgen Tablets Norbrook Labs UK National authorisation (IC) Prescription only medicine to be authorised by a veterinarian (POM-V)
Norodine 80mg Tablets Norbrook Labs UK National authorisation Prescription only medicine to be authorised by a veterinarian (POM-V)
Trimacare 24% Solution for injection Norbrook Labs UK National authorisation (IC) Prescription only medicine to be authorised by a veterinarian (POM-V)
Equibactin vet. Le Vet B.V. EU Mutually recognised procedure Prescription only medicine to be authorised by a veterinarian (POM-V)
Formulation and application details Usually supplied as tablets or in formulations for preparation as injection solutions.


ENVIRONMENTAL FATE

for sulfadiazine

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 130 L3 Moderate
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) 252 V3 -
Boiling point (oC) Decomposes before boiling R4 -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 8.13 X 10-01 Calculated -
Log P -0.09 R4 Low
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC 2.49 R4 -
Note: pKa(2) = 6.48
Vapour pressure at 20oC (mPa) 5.73 X 10-03 V3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) - - -
GUS leaching potential index Click here for a note on the limitations of the GUS index - - -
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -
Refractive Index - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
Soil degradation (days) (aerobic) DT50 (typical) - - -
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
Note: -
Manure DT50 (days) - - -
Aqueous photolysis DT50 (days) at pH 7 Value Stable Q3 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) 5.5 Q3 Fast
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - R4 Moderately mobile
Koc 81
Notes and range General literature states Koc range 37-125 mL/g
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
N4-acetyl-sulfadiazine Ac-SDZ Animals (urinary) - -


ECOTOXICOLOGY

for sulfadiazine

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 1500 F4 Mouse Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) - - -
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) - - -
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 57 F4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.135 F4 Microcystis aeruginosa Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 7.8 R4 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) < 1.00 R4 Selenastrum capricornutum Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for sulfadiazine

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1500 F4 Mouse Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) - - -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints Intraperitoneal LD50 = 750 mg kg-1 V3 Mouse -
Intravenous LD50 = 880 mg kg-1 V3 Rat -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
Elimination route and rate Largely excreted in the urine Q3 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible kidney and renal system toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes IMDG Transport Code is usually 6.1
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases -
EC Safety Classification Click here to view information omn the EU safety phrases S26-S36
WHO Classification None - not a ppp - -
US EPA Classification (formulation) - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for sulfadiazine

Language Name
English sulfadiazine
French sulfadiazine
German Sulfapyrimidin
Danish -
Italian -
Spanish sulfadiazina
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Monday 02 April 2018
Contact: aeru@herts.ac.uk