Sulfadiazine |
Last updated: 27/01/2024 |
(Also known as: adiazine; diazolone; SDZ; SDA; sulfanilamidopyrimidine; sulfapyrimidine) |
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A commonly used synthetically produced livestock antibiotic / antimicrobial with antiparasitic properties | |
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Current | |
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circa 1935, discovered | |
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Multiple uses including bladder and prostate infections, Nocardia infections, or parasitic infections | |
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Dogs; Cats; Horses, Cattle; Poultry; Pigs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₀H₁₀N₄O₂S | |
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C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N | |
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- | |
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SEEPANYCNGTZFQ-UHFFFAOYSA-N | |
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InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14) | |
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Yes |
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Common Name | Relationship | Link |
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sulfadiazine | - |
General status |
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Antiparasitic, Antibacterial, Coccidiostat, Antiprotozoal | |
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Sulfonamide | |
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Synthetic | |
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Inhibits the production of folic acid necessary for the growth and multiplication of bacteria | |
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[Dihydropteroate synthetase, Antagonist] | |
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68-35-9 | |
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200-685-8 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01EW10 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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250.278 | |
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- | |
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4-amino-N-pyrimidin- 2-yl-benzenesulfonamide | |
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4-amino-N-2-pyrimidinylbenzenesulfonamide | |
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Potential groundwater pollutant | |
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- | |
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White to slightly yellow crystalline powder | |
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Formulations |
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Bimamix Oral Suspension | Bimeda Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Diatrim Solution for Injection | Eurovet Animal health B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Equibactin Vet Oral Paste | Le Vet B.V. | GB National authorisation (IC) | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Trimesoxine Tablets | Vetoquinol UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Formulated in a variety of different products including medicated feeds, oral pastes, solutions for injection and oral suspensions |
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130 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Moderate | ||||||||
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252 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Decomposes before boiling | R4 R = Peer reviewed scientific publications 4 = Verified data |
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8.13 X 10-01 | Calculated | - | |||||||
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-0.09 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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2.49 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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pKa(2) = 6.48 | |||||||||||
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5.73 X 10-03 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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17 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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Stable | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Stable | |||||||
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5.5 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Fast | ||||||||
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Soil adsorption and mobility |
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- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately mobile | |||||||
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81 | ||||||||||
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General literature states Koc range 37-125 mL g⁻¹ | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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N4-acetyl-sulfadiazine | Ac-SDZ | Animals (Urine) | - | - |
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Terrestrial ecotoxicology |
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1500 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 57 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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7.8 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
Moderate | ||||||||
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< 1.00 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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1500 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
Moderate | ||||||||
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Intraperitoneal LD₅₀ = 750 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ = 880 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Largely excreted in the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible kidney and renal system toxicant |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Not listed (Not listed) | |||
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Packaging Group III (minor danger) | |||
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sulfadiazine | ||
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sulfadiazine | ||
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Sulfapyrimidin | ||
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sulfadiazina | ||
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Record last updated: | 27/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |