Butorphanol |
![]() Last updated: 08/04/2021 |
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(Also known as: butorfanol) |
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Most commonly used as a narcotic for pain relief | |
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Horses, dogs, cats, ferrets, raccoons and some rodents |
Chemical structure |
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Isomeric | |
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C₂₁H₂₉NO₂ | |
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C1CCC2(C3CC4=C(C2(C1)CCN3CC5CCC5)C=C(C=C4)O)O | |
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C1CC[C@]2([C@H]3CC4=C([C@]2(C1)CCN3CC5CCC5)C=C(C=C4)O)O | |
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IFKLAQQSCNILHL-QHAWAJNXSA-N | |
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InChI=1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1 | |
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Yes |
General status |
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Analgesic, Medicinal drug | |
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Benzylisoquinoline | |
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Synthetic | |
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Intracellular inhibition of adenylate cyclase distrupting normal behaviour of membrane calcium and potassium channels. | |
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[Kappa-type opioid receptor, agonist], [Delta-type opioid receptor, agonist], [Mu-type opioid receptor, agonist] | |
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42408-82-2 | |
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255-808-8 | |
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QN02AF01 | |
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Nervous system: Analgesics | |
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No | |
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No data | |
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327.47 | |
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17-cyclobutylmethyl-morphinan-3,14-diol | |
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Controlled substance | |
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White crystalline solid |
Formulations |
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Alvegesic vet | Alvetra u. Werfft A.G. | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Dolorex 10mg/mL Solution for Injection for horse, dog and cat | Intervet UK Ltd | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Torbutrol Tablets 10mg | Pfizer Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Morphasol 4 mg/ml solution for injection for dogs and cats | aniMedica GmbH | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available in a variety of formulations including solutions for injection and tablets for oral administration |
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Degradation |
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Fate indices |
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Terrestrial ecotoxicology |
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> 17 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 17 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Rat3 = Unverified data of known source |
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Intraspinal TDLo = 0.035 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Women3 = Unverified data of known source |
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Extensively metabolised by the liver and elimination occurs by urine and faecal excretion. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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High doses may cause seizures, falling, salivation, constipation, and muscle twitching |
Handling issues |
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No information available | |||
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None - not a ppp | |||
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butorphanol | ||
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butorfanol | ||
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Record last updated: | 08/04/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |