Doramectin |
Last updated: 23/02/2024 |
(Also known as: UK-67994) |
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A veterinary drug used for the treatment and control of internal parasitosis | |
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Current | |
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1975, introduced | |
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Used to manage gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle and other animals | |
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Cattle; Sheep; Pigs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Doramectin a chiral molecule | |
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C₅₀H₇₄O₁₄ | |
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CC1C=CC=C2COC3C2(C(C=C(C3O)C)C(=O)OC4CC(CC=C(C1OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)O)OC)OC)C)OC7(C4)C=CC(C(O7)C8CCCCC8)C)O | |
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C[C@H]1C=C[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/C([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H](C([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)O[C@@H]1C8CCCCC8 | |
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QLFZZSKTJWDQOS-YDBLARSUSA-N | |
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InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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Doramectin monohydrate | Variant |
General status |
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Antiparasitic, Endoparasitic, Acaricide, Insecticide, Anthelmintic | |
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Avermectin | |
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Synthetic | |
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Broad spectrum, induces rapid, non-spastic paralysis in nematodes and arthropods. Glutamate-gated chloride channel (GluCl) allosteric modulator. | |
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[Glycine receptor subunit alpha-3, Agonist], [Gamma-aminobutyric-acid (GABA) receptor subunit beta-3, Agonist] | |
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117704-25-3 | |
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9832750 | |
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Antiparasitic products, insecticides & repellents: Endectocides | |
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QP54AA03 | |
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No | |
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Allowed substance (Table 1: All mammalian food producing species) | |
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899.11 | |
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- | |
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1'R,2S,4'S,5S,6R,8'R,10'E,12'R,13'S,14'E,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one | |
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25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a | |
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- | |
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UK Environment Agency non-statutory standard for the protection of aquatic life in freshwater and saltwater: 0.001 µg l⁻¹ as annual average, 0.01 µg l⁻¹ as max acceptable conc. | |
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Off-white crystalline solid | |
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Formulations |
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Dectomax 10 mg/ml Solution for Injection for Cattle and Sheep | Elanco Animal Health | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Taurador Pour-on Solution | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Avilable in a variety of formulations including solutions for injection and pour-on products |
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0.025 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Low | ||||||||
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160.5 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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2.95 X 1007 | Calculated | - | |||||||
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7.47 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
High | ||||||||
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1.25 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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12.42 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Peak at 244 nm with shoulders at 238 and 253 nm | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Degradation |
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70 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately persistent | |||||||
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Literature DT₅₀ range 61-79 days | ||||||||||
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22 | R4 R = Peer reviewed scientific publications Sheep faeces4 = Verified data |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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289 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Non-mobile | |||||||
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35900 | ||||||||||
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Literature Koc range 7520 (silty loam) - 86900 (silty clay loam) mL g⁻¹; Koc = 34100 mL g⁻¹ cattle faeces | ||||||||||
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Fate indices |
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-1.02 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Known soil and groundwater metabolites |
None
Other known metabolites |
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3'-O-desmethyl doramectin | - | Cattle (Liver, Faeces) | - | ||||
24-hydroxymethyl doramectin | - | Cattle (Liver, Faeces) | - | ||||
24-hydroxymethyl-3'-O-desmethyl doramectin | - | Cattle (Liver, Faeces) | - |
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Terrestrial ecotoxicology |
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> 1000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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> 2000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Colinus virginianus3 = Unverified data of known source |
Low | ||||||||
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> 1000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Eisenia foetida4 = Verified data |
Low | ||||||||
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Aquatic ecotoxicology |
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0.0051 | E3 E = Manufacturers safety data sheets Oncorhynchus mykiss3 = Unverified data of known source |
High | ||||||||
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0.0001 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
High | ||||||||
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0.000025 | R3 R = Peer reviewed scientific publications Daphnia magna 48 hr NOEC3 = Unverified data of known source |
High | ||||||||
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> 0.42 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio EC₅₀ Embryo3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 1000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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Most of the administered does is eliminated in the faeces, only around 1% is lost in the urine | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Health issues |
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May cause mild tachycardia, hypotension, fever, and hypothermia |
Handling issues |
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Emits toxic fumes under fire conditions IMDG Transport Hazard Class 6.1 |
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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doramectin | ||
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doramectina | ||
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doramectina | ||
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Record last updated: | 23/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |