Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
GET ADDITIONAL DATA HERE!

nandrolone
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for nandrolone

Description: An anabolic steriod that has a variety of uses in veterinary medicine including the correction of negative nitroge nand calcium balance in debility and to aid healing and convalescence

Availability status: -

Introduction & key dates: 1950, first synthesised

Examples of species treated: Cats, Dogs, Pigs

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Isomeric
Chemical formula C18H26O2
Canonical SMILES CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34
Isomeric SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@H]34
International Chemical Identifier key (InChIKey) NPAGDVCDWIYMMC-IZPLOLCNSA-N
International Chemical Identifier (InChI) InChI=1S/C18H26O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-17,20H,2-9H2,1H3/t13-,14+,15+,16-,17-,18-/m0/s1
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Veterinary substance type Hormone substitute, Anabolic steriod, Medicinal drug
Substance group Progesterone steroid
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action An androgen receptor agonist
Molecular targets Androgen receptor, agonist
CAS RN 434-22-0
EC number 207-101-0
CIPAC number -
US EPA chemical code -
PubChem CID -
ATCvet Code QA14AB01
Therapeutic Class Alimentary tract & metabolism: Anabolic agents for systemic use
Controlled Drug? Yes - Group 4
Regulation 37/2010 MRL Classification No data
Molecular mass (g mol-1) 274.4
PIN (Preferred Identification Name) -
IUPAC name 17β-hydroxy-19-nor-4-andro-sten-3-one
CAS name 19-nortestosterone
Other status information USA Superlist DEA Schedule III; Evidence of use in third world countries
Relevant Environmental Water Quality Standards -
Physical state -
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Product Manufacturer Authorisation Route UK Legal Class
Example products using this active Laurabolin 25 mg/ml, solution for injection Intervet UK Ltd UK National authorisation Prescription only medicine to be authorised by a veterinarian (POM-V)
Laurabolin 50 mg/ml, solution for injection Intervet UK Ltd UK National authorisation Prescription only medicine to be authorised by a veterinarian (POM-V)
Formulation and application details Usually supplied as an oil-based injectable solution.


ENVIRONMENTAL FATE

for nandrolone

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 323 V3 Moderate
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) 122 V3 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 4.17 X 1002 Calculated -
Log P 2.62 V3 Low
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) - - -
Henry's law constant at 25oC (Pa m3 mol-1) - - -
GUS leaching potential index Click here for a note on the limitations of the GUS index - - -
Maximum UV-vis absorption L mol-1 cm-1 In ethanol: 241nm = 17000 L3 -
Surface tension (mN m-1) - - -
Refractive Index - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
Soil degradation (days) (aerobic) DT50 (typical) - - -
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
Note: -
Manure DT50 (days) - - -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - CA3 -
Note Not expected to undergo hydrolysis
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - CA3 Slightly mobile
Koc 630
Notes and range Estimated
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
19-norandrosterone 19-NA Human (Urinary) - -
19-noretiocholanolene 19-NE Human (Urinary) - -
5-dihydro-19-nortestosterone dihydronandrolone Human - 5-alpha reductase


ECOTOXICOLOGY

for nandrolone

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) - - -
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) - - -
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) - - -
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) - - -
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for nandrolone

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) - - -
Mammals - Dermal LD50 (mg kg-1 body weight) - - -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public -
Occupational May be absorbed through the skin
Elimination route and rate Rapidly excreted via the urine and faeces CA3 -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A0; B0; C0; D0; E0

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues May cause gastrointestinal problems
May cause headache, unusual tiredness, dizziness, trouble sleeping, habituation, excitation and depression
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R20/21/22
EC Safety Classification Click here to view information omn the EU safety phrases S22, S24/25, S36/37/39
WHO Classification None - not a ppp - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for nandrolone

Language Name
English nandrolone
French -
German -
Danish -
Italian -
Spanish nandrolona
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Tuesday 03 April 2018
Contact: aeru@herts.ac.uk