Kanamycin |
Last updated: 14/01/2024 |
(Also known as: Nebramycin Factor 5; aminodeoxykanamycin; KAN) |
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An antibacterial drug active against both gram-negative and to a lesser extent gram-positive bacteria | |
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Current | |
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1957, discovered | |
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Used, for example, to treat clinical mastitis in lactating dairy cows and other bacterial infections | |
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Cattle; Horses; Pigs; Sheep; Goats; Poultry |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₁₈H₃₆N₄O₁₁ | |
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C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N | |
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C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N | |
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SBUJHOSQTJFQJX-NOAMYHISSA-N | |
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InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1 | |
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Yes |
General status |
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Antibiotic, Antibacterial, Medicinal drug | |
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Aminoglycoside | |
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Natural | |
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Inhibits protein synthesis | |
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[16S rRNA, Antagonist], [30S ribosomal protein S12, Antagonist] | |
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59-01-8 | |
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200-411-7 | |
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Antiinfectives for systemic use: Antibacterials for intramammary use | |
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QJ51RD01 | |
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No | |
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Allowed substance [Table 1: all food producing species except fin fish] | |
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484.50 | |
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2-(aminomethyl)- 6-[4,6-diamino-3- [4-amino-3,5-dihydroxy-6-(hydroxymethyl) tetrahydropyran-2-yl]oxy- 2-hydroxy- cyclohexoxy]- tetrahydropyran- 3,4,5-triol | |
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Formulations |
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Ubrolexin Intramammary Suspension for Lactating Dairy Cows | Boehringer Ingelheim Animal Health UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Current available products are formulated as intramammary suspension solutions for injection |
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1000000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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2.00 X 10-07 | Calculated | - | |||||||
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-6.7 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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7.2 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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4.39 X 10-18 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 5000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 5000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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Subcutaneous LD₅₀ = 4070 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 1515 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Mainly unmetabolised and excreted in the faeces | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May trigger allergic reactions May damage hearing Possible kidney toxicant May cause nephrotoxicity May cause gastrointestinal problems |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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kanamycin | ||
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kanamycine | ||
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kanamicina | ||
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Record last updated: | 14/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |