Ronidazole

Ronidazole	Last updated: 20/10/2025
(Also known as: MCMN; (1-methyl-5-nitroimidazole-2-yl)methyl carbamate)

GENERAL INFORMATION

Description

An antiprotozoal agent used for prevention and treatment of various infections

Examples of veterinary uses

Multiple uses including histomoniasis in turkeys, trichomoniasis in pigeons, genital trichomoniasis in cattle, haemorrhagic enteritis in pigs and Tritrichomonas foetus in cats

Examples of species treated

Cats; Pigeons; Turkeys and other birds; Pig; Cattle

Approval status

VMR 2013/2033 approval status (GB/UK)

Not approved

EU Regulatory approval status

Not approved

Chemical structure

Isomerism

Ronidazole exhibits tautomeric isomerism and potentially stereoisomerism, though the latter is less prominent in its pharmacological context. The molecule contains a nitroimidazole ring, which can undergo tautomerism, typically between the 1H- and 3H-imidazole forms. This tautomerism can subtly influence its chemical reactivity and binding properties. Additionally, ronidazole includes a carbamate side chain, which may allow for rotational isomerism around single bonds, though these do not result in distinct stereoisomers under normal conditions.

Chemical formula

C₆H₈N₄O₄

Canonical SMILES

CN1C(=CN=C1COC(=O)N)[N+](=O)[O-]

Isomeric SMILES

No data

International Chemical Identifier key (InChIKey)

PQFRTXSWDXZRRS-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11)

2D structure diagram/image available?

Yes

Cambridge Crystallographic Data Centre diagrams

Common Name	Relationship	Link
ronidazole	-

General status

Veterinary substance type

Antibiotic, Medicinal drug, Antiparasitic, Antiprotazoal

Substance groups

Nitroimidazole drug

Minimum active substance purity

Known relevant impurities

Substance origin

Synthetic

Mode of action

In vivo antiparasitic and antimycoplasmal activity. Its molecular mechanism involves reduction of the nitro group by microbial enzymes, particularly pyruvate:ferredoxin oxidoreductase, which generates reactive nitro radicals. These radicals then interact with nucleic acids, causing strand breaks and DNA damage, ultimately leading to cell death.

Molecular targets

[Pyruvate:ferredoxin oxidoreductase (PFOR), Antagonist]

CAS RN

7681-76-7

EC number

231-675-1

CIPAC number

US EPA chemical code

PubChem CID

Therapeutic Class

Antiparasitic products, insecticides & repellents: Antiprotozoals

ATCvet Code

QP51AA08

Controlled Drug?

Regulation 37/2010 MRL Classification

Prohibited

Molecular mass

200.15

PIN (Preferred Identification Name)

IUPAC name

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl carbamate

CAS name

1-methyl-2-(carbamoyloxymethyl)-5-nitroimidazole

Global Governance status: Listed (✓) under

UK Poisons List Order 1972	Rotterdam Convention	Montreal Protocol
XNo The Poisons List Order 1972	XNo Rotterdam Convention	XNo Montreal Protocol
Stockholm Convention	OSPAR	EU Water Framework Directive
XNo Stockholm Convention	XNo OSPAR	XNo EU Water Framework Directive

Relevant Environmental Water Quality Standards

Forever chemical

Other status information

Physical state

Pale yellow crystals

Commercial

Property

Value

Availability status

Introduction & key dates

1970s, first synthesis; 1980s, use in vet medicine; 2013, not approved UK

Example manufacturers & suppliers of products using this active now or historically

Oropharma, NL
Columbovet S.R.L. Romania

Example products using this active

Rondiazole capsules
Tricho Plus
Belga
Ridsol-S
Ronida
Ronivet
Ronizol
Turbosol
Trichocure
Trichorex

Formulation and application details

Typically available as capsules, liquids or powders

Commercial production

The production of ronidazole typically begins with the synthesis of a 5-nitroimidazole core, a key pharmacophore responsible for its antiprotozoal activity. This involves nitration of imidazole derivatives to introduce the nitro group at the 5-position. Next, a methyl group is added at the 1-position through alkylation, followed by the attachment of a hydroxymethyl group at the 2-position. This intermediate is then reacted with carbamic acid derivatives to form the final carbamate ester, yielding ronidazole as the active compound.

Impact on climate of production and use

Published GHG data is not available for most pharmaceuticals. However, according to industry, global averages suggest producing 1 kg of a typical active pharmaceutical ingredient can range from 10 to 100 kg CO₂e for small molecule drugs and potentially up to 1000 kg CO₂e for complex biologicals such as vaccines, depending on the drug type, its formulation, complexity of synthesis, solvent recovery, and energy sources used.

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C at pH 7 (mg l⁻¹)

2900

High

Solubility - In organic solvents at 20 °C (mg l⁻¹)

Melting point (°C)

168

Boiling point (°C)

502

Degradation point (°C)

Flashpoint (°C)

258

Octanol-water partition coefficient at pH 7, 20 °C

4.17 X 10^-01

Calculated

Log P

-0.38

Low

Fat solubility of residues

Solubility

Data type

Density (g ml⁻¹)

Dissociation constant pKa) at 25 °C

1.2

Vapour pressure at 20 °C (mPa)

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Surface tension (mN m⁻¹)

Refractive Index

1.651

Environmental release

Degradation

Property

Value

Source; quality score; and other information

Interpretation

Soil degradation (days) (aerobic)

DT₅₀ (typical)

DT₅₀ (lab at 20 °C)

DT₅₀ (field)

DT₉₀ (lab at 20 °C)

DT₉₀ (field)

Note

Manure DT₅₀ (days)

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Note

Water-sediment DT₅₀ (days)

Water phase only DT₅₀ (days)

Sediment phase only DT₅₀ (days)

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

K_oc (mL g⁻¹)

Notes and range

Freundlich

K_f (mL g⁻¹)

K_foc (mL g⁻¹)

¹/_n

Notes and range

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

Bio-concentration factor

BCF (l kg⁻¹)

Low risk

Based on LogP < 3

Low risk

CT₅₀ (days)

Known metabolites

None

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

3400

Rat

Low

Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Birds - Acute LD₅₀ (mg kg⁻¹)

Birds - Short term dietary LC₅₀ (mg kg⁻¹ bw d⁻¹)

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹ dw soil)

Soil micro-organisms

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Non-target plants

Vegetative vigour ER₅₀ (g ha⁻¹)

Seedling emergence ER₅₀ (g ha⁻¹)

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Notes

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps)

Beneficial insects (Predatory mites)

Beneficial insects (Ground beetles)

Beneficial insects (Butterflies)

Contact

Notes

Oral

Notes

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l⁻¹)

Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l⁻¹)

Algae - Acute (growth rate, fresh; mg l⁻¹)

Algae - Chronic (growth rate, fresh; mg l⁻¹)

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

3400

Rat

Low

Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

Mammals - Inhalation LC₅₀ (mg l⁻¹)

Other Mammal toxicity endpoints

Intraperitoneal LD₅₀ = 1500 mg kg⁻¹

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

Dermal penetration studies (%)

Dangerous Substances Directive 76/464

Exposure Routes

Public

Occupational

Mammalian dose elimination route and rate

Rapidly metabolised and eliminated mainly via the urine and faeces, up to 3% is exhaled as carbon dioxide

Health issues

Specific human health issues (hazard-based)

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

No data found

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

No data found

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

No data found

General human health issues

US FDA - possibly carcinogenic

Handling issues

Property

Value and interpretation

General

No information available

CLP classification 2013

Health: H302, H361, H373

WHO Classification

Not listed (Not listed)

UN Number

Waste disposal & packaging

Shelf-life, storage, stability and reactivity

TRANSLATIONS

Language

Name

English

ronidazole

French

ronidazole

German

Ronidazol

Danish

Italian

Spanish

ronidazol

Greek

Polish

Swedish

Hungarian

Dutch

Norwegian

Record last updated:	20/10/2025
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242

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