Albendazole |
![]() Last updated: 14/05/2022 |
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(Also known as: SLA 3505; SKF-62979) |
SUMMARY |
A potent anthelmintic insecticide. It has a low aqueous solubility. Little has been published regarding its behaviour in the environment or its toxicity to fauna and flora. It is moderately toxic to humans and may cause reproduction or fertility problems. . |
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Primary use is as a topical pesticide for livestock for control of parasites in particular various worm infestations. | |
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1977, UK | |
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Domestic and farm animals including cattle & sheep |
Chemical structure |
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C₁₂H₁₅N₃O₂S | |
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CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC | |
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HXHWSAZORRCQMX-UHFFFAOYSA-N | |
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InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) | |
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Yes |
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Common Name | Relationship | Link |
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albendazole | - | ![]() |
General status |
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Insecticide, Antiparasitic, Anthelmintic | |
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Benzimidazole | |
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>98% | |
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Synthetic | |
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Causes degenerative alterations in parasite cell walls, inhibiting tubulin polymerization which results in the loss of cytoplasmic microtubules. | |
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[Tubulin alpha-3 chain, antagonist], [Tubulin beta-2C chain, antagonist], [Fumarate reductase flavoprotein subunit, antagonist] | |
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54965-21-8 | |
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259-414-7 | |
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None allocated | |
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QP52AC11 | |
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Antiparasitic products, insecticides & repellents: Anthelmintics | |
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Allowed substance (Table 1: Ruminants) | |
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265.33 | |
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methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate | |
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5-(propylthio)-1H-benzimidazol-2-yl, methyl ester carbamic acid | |
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Off-white crystalline powder |
Formulations |
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Albenil 2.5% SC Oral Suspension | Virbac Ltd | UK National authorisation (IC) | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Albensure 10% Oral Supension | Animax Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Endospec SC Oral Suspension | Cross Vetpharm Group | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Ovispec SC Oral Suspension | Janssen-Cilag Ltd | UK National authorisation (IC) | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Usually administered orally as tablets or solution |
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0.56 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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209 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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1.86 X 1001 | Calculated | - | |||||||
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1.27 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) 3 = Unverified data of known source |
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10.26 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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pKa(2) = 2.80 | |||||||||||
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Degradation |
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Soil adsorption and mobility |
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- | Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
Non-mobile | |||||||
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17650 | ||||||||||
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Literature range 7800-27500 | ||||||||||
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Fate indices |
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Other known metabolites |
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albendazole sulfoxide | - | Human (Liver) | - | - | |||||
albendazole sulfone | - | Human (Liver) | - | - |
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Terrestrial ecotoxicology |
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1320 | Q3 Q = Miscellaneous internet resources Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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1320 | Q3 Q = Miscellaneous internet resources Rat3 = Unverified data of known source |
Moderate | ||||||||
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Intravenous LD₅₀ = 265 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rat3 = Unverified data of known source |
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0.005 | Q2 Q = Miscellaneous internet resources 2 = Unverified data of unknown source |
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Rapidly metabolised and lost via (probably) biliary excretion. Little is found in the urine. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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Mutagenic potential Possible tetragenic effect Possible liver toxicant |
Handling issues |
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No information available | |||
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Health: H315, H319, H335, H360, H361 Environment: H400, H410 |
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None - not a ppp | |||
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albendazole | ||
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albendazole | ||
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Albendazol | ||
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albendazol | ||
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albendazol | ||
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Record last updated: | 14/05/2022 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |