Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
GET ADDITIONAL DATA HERE!
milbemectin (Ref: SL 8601)
** B 41 ** E 187 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for milbemectin

Description: An insecticide and acaricide effective against all development stages of mites and some other insects

Example pests controlled: Spider mites; Tarsonemid mites; Leaf miners; Pinewood nematode

Example applications: Soft fruit including Straweberry, blackberry, currants, raspberry, gooseberry; Apple, Pear, Cherry, Plum; Orange; Eggplants; Ornamentals

Efficacy & activity: Efficacy proven via field trials

Appearance and life cycle: -

Availability status: Current

Introduction & key dates: 1990, Japan

Taxonomic classification: -

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Germany/Netherlands
Date inclusion expires 31/07/2020
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Known to used in the following countries: EU, Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Milbemectin is a complex molecule with 10 chiral features. The technical material is a mixture of milbemycin A3 and milbemycin A4 in a ratio of 30:70,
Chemical formula C31H44O7 (milbemycin A3) + C32H46O7 (milbemycin A4)
Canonical SMILES CC1CCC2(CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)C)OC1C
Isomeric SMILES C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)\C)O[C@@H]1C
International Chemical Identifier key (InChIKey) VOZIAWLUULBIPN-LRBNAKOISA-N
International Chemical Identifier (InChI) InChI=1S/C31H44O7/c1-18-7-6-8-23-17-35-28-27(32)21(4)14-26(31(23,28)34)29(33)36-25-15-24(10-9-19(2)13-18)38-30(16-25)12-11-20(3)22(5)37-30/h6-9,14,18,20,22,24-28,32,34H,10-13,15-17H2,1-5H3/b7-6+,19-9+,23-8+/t18-,20-,22?,24?,25-,26-,27+,28+,30-,31+/m0/s1
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Biopesticide type Insecticide, Acaricide, Nematicide
Substance group Micro-organism derived
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Natural
Mode of action Contact and stomach action, acting on the targets nervous system
Substance source Isolated from the soil bacterium Streptomyces hygroscopicus (Jensen) Waks and henrici subsp. aureolacrimosus
Substance production Produced by fermentation
Uses Crop protection
Target pests Mainly mites but also active against leaf miners
Target host Citrus fruit, top fruit, soft fruit, aubergines and others
Farming system suitability -
CAS RN 51596-10-2
Alternative/old CAS RN 51596-11-3
EC number -
CIPAC number 660
US EPA chemical code -
PubChem CID -
Molecular mass (g mol-1) 535.7
PIN (Preferred Identification Name) -
IUPAC name -
CAS name (6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-ethylmilbemycin B mixture with (6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-methylmilbemycin B
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 6
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White crystalline powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Product Manufacturer
Example products milbeKNOCK group 6B Miticide Sipcam
Ultiflora Miticide Summit Agro, Australia
Mesa Gowan Company
Formulation and application details Usually supplied as an emulsifiable concentrate or wettable powder.


ENVIRONMENTAL FATE

for milbemectin

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 3.6 A4 Low
Solubility - In organic solvents at 20oC (mg l-1) 243000 A4 - Ethyl acetate -
5060 A5 - n-Heptane -
251000 A4 - Methanol -
284000 A5 - Xylene -
Melting point (oC) 205.2 A5 -
Boiling point (oC) Not observed A5 -
Degradation point (oC) 275 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 6.31 X 1006 Calculated -
Log P 6.8 A4 High
Bulk density (g ml-1)/Specific gravity 1.13 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 1.30 X 10-02 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 9.93 X 10-04 A5 Non-volatile
Maximum UV-vis absorption L mol-1 cm-1 At all pHs - Max @ 244nm & shoulders @ 238nm & 252nm A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 43 A4 Moderately persistent
DT50 (lab at 20oC) 43 A4 Moderately persistent
DT50 (field) 8.5 A4 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Lab studies DT50 range for milbemycin A4 21-82 days, field study DT50 range for milbemcyin A3 8.1-8.8 days (USA)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 5.1 R3 -
Note Tea, green leaves, n=1
Aqueous photolysis DT50 (days) at pH 7 Value - A5 -
Note 3.1days @ pH5
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 2.6 A5 Non-persistent
Note pH variable: 0.93days @ pH5, 4.1days @ pH9
Water-sediment DT50 (days) 86 A5 Moderately fast
Water phase only DT50 (days) 2.0 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - E4 Slightly mobile
Koc 2975
Notes and range Industry data Koc range 1550-4400 mL/g
Freundlich Kf 63.3 A5 Slightly mobile
Kfoc 2843
1/n 0.98
Notes and range EU dossier Kf range 12-153 g/Kg, Kfoc range 1550-4400 g/Kg, Soils =4
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
27-hydroxy-milbemycin A4 This metabolite may cause environmental pollution, click here for further information Soil   0.140   Major fraction; Relevant
27-keto-milbemycin A4 This metabolite may cause environmental pollution, click here for further information Soil   0.118   Major fraction; Relevant


ECOTOXICOLOGY

for milbemectin

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 95 A5 Whole fish Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 456 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 3.0 E3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 347 A5 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) 199 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 0.0044 A5 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) 0.00065 A5 Anas platyrhynchos High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.011 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.00012 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.0063 A5 Chironomus riparius High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 0.62 E4 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) > 2.0 A4 Selenastrum capricornutum, 120 hour Low
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.025 L3 Apis mellifera High
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.026 A5 Apis mellifera High
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 9.7 A5 Bombus terrestris Moderate
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 10 A5 Bombus terrestris Moderate
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 28.5 A5 Eisenia foetida Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) 0.109 A5 Eisenia foetida Moderate
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: Field rate
Q2 Galendromus occidentalis
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: Field rate
Q2 Neoseiulus fallacis
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.1mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for milbemectin

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 456 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 3.0 A5 Rat, 4 hr (whole body) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.03 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.03 A5 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.014 A5 Dog, SF=100 -
Dermal penetration studies (%) 10 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public -
Occupational -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A0; B0; C0; D0; E3

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Possible liver, kidney, adrenals and uterus toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of mists
Not explosive or oxidising
Flammable
CLP classification 2013 Health: H302, H332
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R65, R67
Xi - Irritant: R37
H - Handling risks: R10
N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for milbemectin

Language Name
English milbemectin
French milbectine
German Milbemectin
Danish milbemectin
Italian milbemectina
Spanish milbemectin
Greek -
Slovenian milbemektin
Polish milbemektyna
Swedish -
Hungarian -
Dutch -

Record last updated: Tuesday 15 October 2019
Contact: aeru@herts.ac.uk