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amitrole
** aminotriazole ** amitolamitril ** Translations

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SUMMARY

Amitrole is a triazole herbicide that is currently approved for use in the EU and in other countries. It is volatile, highly soluble in water and, based on its chemical properties, is moderately mobile with some potential for leaching to groundwater. It is not persistent in soil systems, degradation being very rapid but may be expected to persistent in surface water under normal conditions. Amitrole has a low mammalian toxicity and is not expected to bioaccumulate. It has a moderate toxicity to most terrestrial and aquatic species.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for amitrole

Description: A triazole herbicide used to control a wide range of perennial grasses and broad-leaved weeds.

Example pests controlled: Poison ivy; Nutgrass; Water couch; Water hyacinth; Clovers; Thistles; Chickweed; Wild oats; Brambles

Example applications: Vineyards; Non-cropped situations including roadsides; drains; ditches; Eucalupytus; Pine plantations

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1953, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur France
Date inclusion expires Expired
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C2H4N4
Canonical SMILES C1=NNC(=N1)N
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) KLSJWNVTNUYHDU-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Triazole
Minimum active substance purity 910 g/kg
Known relevant impurities EU dossier - N-(1H-(1,2,4)-triazol-3-yl)-formamide <13 g/kg; 4H-(1,2,4)-triazole-3,4-diamine < 12 g/kg; methanoic acid <7 g/kg
Substance origin Synthetic
Mode of action Translocated, foliar-acting, non-selective action. Inhibition of lycopene cyclase.
CAS RN 61-82-5
EC number 200-521-5
CIPAC number 90
US EPA chemical code 004401
PubChem CID 1639
Molecular mass (g mol-1) 84.08
PIN (Preferred Identification Name) 1H-1,2,4-triazol-3-amine
IUPAC name 1H-1,2,4-triazol-3-amine
CAS name 1H-1,2,4-triazol-3-amine
Other status information OSPAR candidate
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) F3
Herbicide Resistance Classification (WSSA) 11
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White crystals
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • NuFarm
  • Bayer
  • Union Carbide
  • American Cyanamid
  • Makhteshim-Agan
  • Fairmount
Example products using this active
  • Weedazol TL
  • Herbizole
  • Diurol
  • Amerol
  • CA 2735
  • Amizol
  • Cytrol
UK LERAP status None
Formulation and application details Spray application usually formulated as a concentrated liquid or soluble powder.


ENVIRONMENTAL FATE

for amitrole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 264000 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 20 A5 - Toluene -
27000 A5 - Isopropanol -
100 A5 - Dichloromethane -
2900 A5 - Acetone -
Melting point (oC) 155 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.07 X 10-01 Calculated -
Log P -0.97 A5 Low
Bulk density (g ml-1)/Specific gravity 1.14 A5 -
Dissociation constant (pKa) at 25oC 4.14 A5 -
Note: Weak acid pKa(2) 10.7
Vapour pressure at 20oC (mPa) 0.033 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.76 X 10-08 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.79 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.52 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 198nm = 4947 A5 -
Surface tension (mN m-1) 73.3 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 7.4 A5 Non-persistent
DT50 (lab at 20oC) 7.4 A5 Non-persistent
DT50 (field) 16 A5 Non-persistent
DT90 (lab at 20oC) 82.88 A5 -
DT90 (field) 350 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 4.3-17.6 dats; DT90 range 11.2-289.7, soils=5; Field studies DT50 range 6.8-28.1 days, DT90 range 109.3-717.6, soils=4
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Not pH sensitive
Water-sediment DT50 (days) 309 A5 Slow
Water phase only DT50 (days) 71 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 1.60 A5 Moderately mobile
Kfoc 87
1/n 0.80
Notes and range EU dossier, Kf range 0.152-3.79 mL/g, kfoc range 20-202, 1/n range 0.65-0.87, Soils=8
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
1,2,4-triazole (Ref: CGA 71019) Soil   -   Major fraction


ECOTOXICOLOGY

for amitrole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 2.4 A5 Low potential
CT50 (days) 7 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2150 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5000 ppm A3 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 1000 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 100 A5 Oncorhynchus mykiss Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 6.1 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.32 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 2.8 F4 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 2.5 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 2.3 A4 Scenedemus subspicatus, 72 hour Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 1 J4 Chlorella vulgaris Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 152 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 448 A5 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 80 Mortality
Dose: 4.72 kg ha-1
A5 Aphidius colemani, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 4.72 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: Transient retardation, recovery after 42 days
Carbon mineralisation: No significant adverse effect
A3
Dose: Not stated
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for amitrole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2500 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 0.439 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.001 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.001 A5 Rat, 90 day, SF=100 -
Dermal penetration studies (%) 25 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Minimal risk of dietary exposure, some risk to bystanders
Occupational Risk of exposure, PPE required
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible thyroid toxicant
IARC group 3 carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes IMDG Transport Code is usually 9
CLP classification 2013 Health: H361d, H373
Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases Reproduction risk category 3: R63
Xn - Harmful: R48/22
N - Dangerous for the environment: R51, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S13, S36/37, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for amitrole

Language Name
English amitrole
French amitrole
German Amitrol
Danish amitrol
Italian amitrolo
Spanish amitrol
Greek -
Slovenian amitrol
Polish amitrol
Swedish -
Hungarian -
Dutch amitrol

Record last updated: Monday 28 May 2018
Contact: aeru@herts.ac.uk
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